ID:RPR1A_HUMAN DESCRIPTION: RecName: Full=Regulation of nuclear pre-mRNA domain-containing protein 1A; AltName: Full=Cyclin-dependent kinase inhibitor 2B-related protein; AltName: Full=p15INK4B-related protein; FUNCTION: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle. SUBUNIT: Associates with the RNA polymerase II complex. INDUCTION: Up-regulated in cells overexpressing CDKN2B. SIMILARITY: Belongs to the UPF0400 (RTT103) family. SIMILARITY: Contains 1 CID domain. SEQUENCE CAUTION: Sequence=AAH10136.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF04818 - CID domain PF16566 - Cell-cycle alteration and expression-elevated protein in tumour
SCOP Domains: 48371 - ARM repeat 48464 - ENTH/VHS domain
ModBase Predicted Comparative 3D Structure on Q96P16
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0042802 identical protein binding
Biological Process: GO:0042795 snRNA transcription from RNA polymerase II promoter GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain
Cellular Component: GO:0005654 nucleoplasm GO:0016591 DNA-directed RNA polymerase II, holoenzyme
Descriptions from all associated GenBank mRNAs
BC000225 - Homo sapiens regulation of nuclear pre-mRNA domain containing 1A, mRNA (cDNA clone MGC:3112 IMAGE:3350951), complete cds. AF419845 - Homo sapiens cyclin-dependent kinase inhibitor-related protein (P15RS) mRNA, complete cds. JD491028 - Sequence 472052 from Patent EP1572962. JD432763 - Sequence 413787 from Patent EP1572962. JD312812 - Sequence 293836 from Patent EP1572962. JD360230 - Sequence 341254 from Patent EP1572962. JD264318 - Sequence 245342 from Patent EP1572962. JD226166 - Sequence 207190 from Patent EP1572962. JD111014 - Sequence 92038 from Patent EP1572962. JD355336 - Sequence 336360 from Patent EP1572962. JD302194 - Sequence 283218 from Patent EP1572962. JD474503 - Sequence 455527 from Patent EP1572962. JD491030 - Sequence 472054 from Patent EP1572962. JD314585 - Sequence 295609 from Patent EP1572962. JD365755 - Sequence 346779 from Patent EP1572962. JD322389 - Sequence 303413 from Patent EP1572962. JD276800 - Sequence 257824 from Patent EP1572962. JD226656 - Sequence 207680 from Patent EP1572962. JD366074 - Sequence 347098 from Patent EP1572962. JD146051 - Sequence 127075 from Patent EP1572962. JD337472 - Sequence 318496 from Patent EP1572962. JD140755 - Sequence 121779 from Patent EP1572962. JD312926 - Sequence 293950 from Patent EP1572962. JD316877 - Sequence 297901 from Patent EP1572962. JD557004 - Sequence 538028 from Patent EP1572962. AK001518 - Homo sapiens cDNA FLJ10656 fis, clone NT2RP2006038. JD331638 - Sequence 312662 from Patent EP1572962. JD559746 - Sequence 540770 from Patent EP1572962. JD233457 - Sequence 214481 from Patent EP1572962. JD284658 - Sequence 265682 from Patent EP1572962. JD565527 - Sequence 546551 from Patent EP1572962. JD244531 - Sequence 225555 from Patent EP1572962. JD267184 - Sequence 248208 from Patent EP1572962. JD167314 - Sequence 148338 from Patent EP1572962. JD110075 - Sequence 91099 from Patent EP1572962. AK292907 - Homo sapiens cDNA FLJ77299 complete cds. JD533960 - Sequence 514984 from Patent EP1572962. JD204312 - Sequence 185336 from Patent EP1572962. JD372849 - Sequence 353873 from Patent EP1572962. AK314569 - Homo sapiens cDNA, FLJ95398. KJ902788 - Synthetic construct Homo sapiens clone ccsbBroadEn_12182 RPRD1A gene, encodes complete protein. CU674092 - Synthetic construct Homo sapiens gateway clone IMAGE:100022433 5' read P15RS mRNA. BC010136 - Homo sapiens regulation of nuclear pre-mRNA domain containing 1A, mRNA (cDNA clone MGC:19513 IMAGE:4109857), complete cds. AK056810 - Homo sapiens cDNA FLJ32248 fis, clone PROST1000123. DQ892910 - Synthetic construct clone IMAGE:100005540; FLH190752.01X; RZPDo839D0876D hypothetical protein FLJ10656 (P15RS) gene, encodes complete protein. EU176720 - Synthetic construct Homo sapiens clone IMAGE:100011524; FLH190751.01L; RZPDo839E08255D hypothetical protein FLJ10656 (P15RS) gene, encodes complete protein.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q96P16 (Reactome details) participates in the following event(s):
R-HSA-6810235 RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain R-HSA-6814885 CBCAP complex binds 7-methylguanosine cap of snRNA R-HSA-6807505 RNA polymerase II transcribes snRNA genes R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription)
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
