Human Gene S100A16 (ENST00000368706.9_7) from GENCODE V47lift37
  Description: S100 calcium binding protein A16, transcript variant 4 (from RefSeq NR_133645.2)
Gencode Transcript: ENST00000368706.9_7
Gencode Gene: ENSG00000188643.11_9
Transcript (Including UTRs)
   Position: hg19 chr1:153,579,362-153,585,613 Size: 6,252 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr1:153,580,010-153,580,627 Size: 618 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:153,579,362-153,585,613)mRNA (may differ from genome)Protein (103 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: S10AG_HUMAN
DESCRIPTION: RecName: Full=Protein S100-A16; AltName: Full=Aging-associated gene 13 protein; AltName: Full=Protein S100-F; AltName: Full=S100 calcium-binding protein A16;
FUNCTION: Calcium-binding protein. Binds one calcium ion per monomer.
SUBUNIT: Homodimer.
SUBCELLULAR LOCATION: Nucleus, nucleolus. Cytoplasm. Note=Primarily nucleolar. Translocates from the nucleolus to the cytoplasm in response to an increase of intracellular calcium levels.
SIMILARITY: Belongs to the S-100 family.
SIMILARITY: Contains 2 EF-hand domains.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: S100A16
Diseases sorted by gene-association score: robinow syndrome (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 846.03 RPKM in Esophagus - Mucosa
Total median expression: 3255.04 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -99.70212-0.470 Picture PostScript Text
3' UTR -218.50648-0.337 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011992 - EF-hand-like_dom
IPR018247 - EF_Hand_1_Ca_BS
IPR018249 - EF_HAND_2
IPR001751 - S100/CaBP-9k_CS

Pfam Domains:
PF01023 - S-100/ICaBP type calcium binding domain
PF13202 - EF hand
PF13833 - EF-hand domain pair

SCOP Domains:
47473 - EF-hand

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2L50 - NMR MuPIT 2L51 - NMR MuPIT 3NXA - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q96FQ6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding

Biological Process:
GO:0051592 response to calcium ion

Cellular Component:
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  BC095462 - Homo sapiens S100 calcium binding protein A16, mRNA (cDNA clone MGC:111357 IMAGE:30553208), complete cds.
AY762098 - Homo sapiens aging-associated protein 13 (AAG13) mRNA, complete cds.
BC010541 - Homo sapiens S100 calcium binding protein A16, mRNA (cDNA clone MGC:17528 IMAGE:3458906), complete cds.
BC019099 - Homo sapiens S100 calcium binding protein A16, mRNA (cDNA clone MGC:29661 IMAGE:5013080), complete cds.
LF206202 - JP 2014500723-A/13705: Polycomb-Associated Non-Coding RNAs.
U23859 - Human clone mcag11 chromosome 1 CAG repeat region.
JD390746 - Sequence 371770 from Patent EP1572962.
JD101739 - Sequence 82763 from Patent EP1572962.
LF352391 - JP 2014500723-A/159894: Polycomb-Associated Non-Coding RNAs.
JD262293 - Sequence 243317 from Patent EP1572962.
JD295042 - Sequence 276066 from Patent EP1572962.
U92985 - Homo sapiens clone DT1P1A7 mRNA, CAG repeat region.
JD219620 - Sequence 200644 from Patent EP1572962.
AK290804 - Homo sapiens cDNA FLJ76552 complete cds, highly similar to Homo sapiens S100 calcium binding protein A16 (S100A16), mRNA.
JD132256 - Sequence 113280 from Patent EP1572962.
JD290089 - Sequence 271113 from Patent EP1572962.
JD325661 - Sequence 306685 from Patent EP1572962.
JD403644 - Sequence 384668 from Patent EP1572962.
JD384194 - Sequence 365218 from Patent EP1572962.
JD070609 - Sequence 51633 from Patent EP1572962.
JD236779 - Sequence 217803 from Patent EP1572962.
JD068578 - Sequence 49602 from Patent EP1572962.
DQ894939 - Synthetic construct Homo sapiens clone IMAGE:100009399; FLH179633.01L; RZPDo839A10131D S100 calcium binding protein A16 (S100A16) gene, encodes complete protein.
DQ893590 - Synthetic construct clone IMAGE:100006220; FLH179637.01X; RZPDo839A10132D S100 calcium binding protein A16 (S100A16) gene, encodes complete protein.
AY221961 - Homo sapiens S100F mRNA, complete cds.
KJ895544 - Synthetic construct Homo sapiens clone ccsbBroadEn_04938 S100A16 gene, encodes complete protein.
LF352390 - JP 2014500723-A/159893: Polycomb-Associated Non-Coding RNAs.
JD075701 - Sequence 56725 from Patent EP1572962.
JD275289 - Sequence 256313 from Patent EP1572962.
JD444515 - Sequence 425539 from Patent EP1572962.
JD343187 - Sequence 324211 from Patent EP1572962.
MA587968 - JP 2018138019-A/159894: Polycomb-Associated Non-Coding RNAs.
MA587967 - JP 2018138019-A/159893: Polycomb-Associated Non-Coding RNAs.
MA441779 - JP 2018138019-A/13705: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K439, AAG13, D3DV52, ENST00000368706.1, ENST00000368706.2, ENST00000368706.3, ENST00000368706.4, ENST00000368706.5, ENST00000368706.6, ENST00000368706.7, ENST00000368706.8, NR_133645, Q5RHS6, Q96FQ6, S100A16 , S100F, S10AG_HUMAN, uc318gzh.1, uc318gzh.2
UCSC ID: ENST00000368706.9_7
RefSeq Accession: NM_080388.3
Protein: Q96FQ6 (aka S10AG_HUMAN or S116_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.