Human Gene SAC3D1 (ENST00000652489.1_3) from GENCODE V47lift37
  Description: SAC3 domain containing 1, transcript variant 1 (from RefSeq NM_013299.4)
Gencode Transcript: ENST00000652489.1_3
Gencode Gene: ENSG00000168061.17_11
Transcript (Including UTRs)
   Position: hg19 chr11:64,808,682-64,812,300 Size: 3,619 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr11:64,808,765-64,812,199 Size: 3,435 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:64,808,682-64,812,300)mRNA (may differ from genome)Protein (358 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: F8WC89_HUMAN
DESCRIPTION: SubName: Full=SAC3 domain-containing protein 1;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: SAC3D1
Diseases sorted by gene-association score: colonic benign neoplasm (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D016604 Aflatoxin B1
  • C517041 (4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)
  • C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl
  • C532162 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine
  • D000082 Acetaminophen
  • D001564 Benzo(a)pyrene
  • D002945 Cisplatin
  • D003300 Copper
  • D019327 Copper Sulfate
  • D003375 Coumestrol
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -26.5083-0.319 Picture PostScript Text
3' UTR -30.20101-0.299 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005062 - SAC3/GANP/Nin1/mts3/eIF-3-p25

Pfam Domains:
PF03399 - SAC3/GANP family

ModBase Predicted Comparative 3D Structure on F8WC89
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Descriptions from all associated GenBank mRNAs
  BC007448 - Homo sapiens SAC3 domain containing 1, mRNA (cDNA clone IMAGE:3010650), containing frame-shift errors.
U79266 - Human clone 23627 mRNA, complete cds.
AB590070 - Synthetic construct DNA, clone: pFN21AE0271, Homo sapiens SAC3D1 gene for SAC3 domain containing 1, without stop codon, in Flexi system.
DQ597526 - Homo sapiens piRNA piR-35592, complete sequence.
JD124898 - Sequence 105922 from Patent EP1572962.
DQ584737 - Homo sapiens piRNA piR-51849, complete sequence.
DQ600317 - Homo sapiens piRNA piR-38383, complete sequence.
JD343739 - Sequence 324763 from Patent EP1572962.
JD276332 - Sequence 257356 from Patent EP1572962.
JD533577 - Sequence 514601 from Patent EP1572962.
JD223341 - Sequence 204365 from Patent EP1572962.
JD231721 - Sequence 212745 from Patent EP1572962.
JD250085 - Sequence 231109 from Patent EP1572962.
JD193680 - Sequence 174704 from Patent EP1572962.
JD415494 - Sequence 396518 from Patent EP1572962.
JD103961 - Sequence 84985 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: F8WC89, F8WC89_HUMAN, NM_013299, SAC3D1 , uc328ujz.1, uc328ujz.2
UCSC ID: ENST00000652489.1_3
RefSeq Accession: NM_013299.4
Protein: F8WC89

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.