Human Gene SCAMP2 (ENST00000268099.13_7) from GENCODE V47lift37

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Description: secretory carrier membrane protein 2, transcript variant 2 (from RefSeq NM_005697.5)
Gencode Transcript: ENST00000268099.13_7
Gencode Gene: ENSG00000140497.16_11
Transcript (Including UTRs)
Position: hg19 chr15:75,136,071-75,165,706 Size: 29,636 Total Exon Count: 9 Strand: -
Coding Region
Position: hg19 chr15:75,137,424-75,165,596 Size: 28,173 Coding Exon Count: 9

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr15:75,136,071-75,165,706)			mRNA (may differ from genome)		Protein (329 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	Wikipedia
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: SCAM2_HUMAN DESCRIPTION: RecName: Full=Secretory carrier-associated membrane protein 2; Short=Secretory carrier membrane protein 2; FUNCTION: Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface. SUBUNIT: Interacts with SLC6A4 and SLC9A7. SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Widely expressed. SIMILARITY: Belongs to the SCAMP family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C023514 2,6-dinitrotoluene D000082 Acetaminophen D000643 Ammonium Chloride D019327 Copper Sulfate D005839 Gentamicins D007854 Lead D018817 N-Methyl-3,4-methylenedioxyamphetamine D011748 Pyrogallol D012601 Scopolamine Hydrobromide D018038 Sodium Selenite D012999 Soman D013749 Tetrachlorodibenzodioxin C006780 bisphenol A C012301 domoic acid

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 60.70 RPKM in Colon - Transverse Total median expression: 1317.69 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-44.80	110	-0.407	Picture	PostScript	Text
3' UTR	-503.40	1353	-0.372	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR007273 - SCAMP

Pfam Domains:
PF04144 - SCAMP family

ModBase Predicted Comparative 3D Structure on O15127


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details		Gene Details
Gene Sorter	Gene Sorter		Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005515 protein binding Biological Process: GO:0006892 post-Golgi vesicle-mediated transport GO:0015031 protein transport Cellular Component: GO:0005768 endosome GO:0005794 Golgi apparatus GO:0016020 membrane GO:0016021 integral component of membrane GO:0030133 transport vesicle GO:0032588 trans-Golgi network membrane GO:0043231 intracellular membrane-bounded organelle GO:0055038 recycling endosome membrane GO:0070062 extracellular exosome

Descriptions from all associated GenBank mRNAs


	AK096376 - Homo sapiens cDNA FLJ39057 fis, clone NT2RP7013374, highly similar to Secretory carrier-associated membrane protein 2. AK096794 - Homo sapiens cDNA FLJ39475 fis, clone PROST2013121, highly similar to SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN 2. AF005038 - Homo sapiens secretory carrier membrane protein (SCAMP2) mRNA, complete cds. BC001376 - Homo sapiens secretory carrier membrane protein 2, mRNA (cDNA clone MGC:1284 IMAGE:3050527), complete cds. BC004385 - Homo sapiens secretory carrier membrane protein 2, mRNA (cDNA clone MGC:10855 IMAGE:3617954), complete cds. HM005632 - Homo sapiens clone HTL-S-219p testis secretory sperm-binding protein Li 219p mRNA, complete cds. AK291884 - Homo sapiens cDNA FLJ77721 complete cds, highly similar to Homo sapiens secretory carrier membrane protein 2 (SCAMP2), mRNA. JD525617 - Sequence 506641 from Patent EP1572962. JD556763 - Sequence 537787 from Patent EP1572962. JD501027 - Sequence 482051 from Patent EP1572962. JD131732 - Sequence 112756 from Patent EP1572962. JD254336 - Sequence 235360 from Patent EP1572962. JD357228 - Sequence 338252 from Patent EP1572962. AK315516 - Homo sapiens cDNA, FLJ96582, Homo sapiens secretory carrier membrane protein 2 (SCAMP2), mRNA. CR456800 - Homo sapiens full open reading frame cDNA clone RZPDo834A1018D for gene SCAMP2, secretory carrier membrane protein 2; complete cds, incl. stopcodon. KJ892908 - Synthetic construct Homo sapiens clone ccsbBroadEn_02302 SCAMP2 gene, encodes complete protein.

Other Names for This Gene


	Alternate Gene Symbols: B2RDF0, ENST00000268099.1, ENST00000268099.10, ENST00000268099.11, ENST00000268099.12, ENST00000268099.2, ENST00000268099.3, ENST00000268099.4, ENST00000268099.5, ENST00000268099.6, ENST00000268099.7, ENST00000268099.8, ENST00000268099.9, NM_005697, O15127, Q9BQE8, SCAM2_HUMAN, uc317imr.1, uc317imr.2 UCSC ID: ENST00000268099.13_7 RefSeq Accession: NM_005697.5 Protein: O15127 (aka SCAM2_HUMAN or SCA2_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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