Human Gene SCAMP3 (ENST00000302631.8_7) from GENCODE V47lift37
  Description: secretory carrier membrane protein 3, transcript variant 1 (from RefSeq NM_005698.4)
Gencode Transcript: ENST00000302631.8_7
Gencode Gene: ENSG00000116521.12_9
Transcript (Including UTRs)
   Position: hg19 chr1:155,225,772-155,232,151 Size: 6,380 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg19 chr1:155,226,064-155,231,942 Size: 5,879 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:155,225,772-155,232,151)mRNA (may differ from genome)Protein (347 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: SCAM3_HUMAN
DESCRIPTION: RecName: Full=Secretory carrier-associated membrane protein 3; Short=Secretory carrier membrane protein 3;
FUNCTION: Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.
SUBUNIT: Interacts with NEDD4 and NEDD4L.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Widely expressed, with highest expression in heart and skeletal muscle.
PTM: Monoubiquitinated.
SIMILARITY: Belongs to the SCAMP family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 36.23 RPKM in Adrenal Gland
Total median expression: 1022.30 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -84.40209-0.404 Picture PostScript Text
3' UTR -91.40292-0.313 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007273 - SCAMP

Pfam Domains:
PF04144 - SCAMP family

ModBase Predicted Comparative 3D Structure on O14828
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0031625 ubiquitin protein ligase binding

Biological Process:
GO:0006892 post-Golgi vesicle-mediated transport
GO:0015031 protein transport

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  BC000161 - Homo sapiens secretory carrier membrane protein 3, mRNA (cDNA clone MGC:5222 IMAGE:2901296), complete cds.
AF005039 - Homo sapiens secretory carrier membrane protein (SCAMP3) mRNA, complete cds.
BC005135 - Homo sapiens secretory carrier membrane protein 3, mRNA (cDNA clone MGC:1388 IMAGE:3510027), complete cds.
BC010505 - Homo sapiens secretory carrier membrane protein 3, mRNA (cDNA clone MGC:17478 IMAGE:3452347), complete cds.
JD499556 - Sequence 480580 from Patent EP1572962.
JD387883 - Sequence 368907 from Patent EP1572962.
JD107022 - Sequence 88046 from Patent EP1572962.
JD084703 - Sequence 65727 from Patent EP1572962.
JD114883 - Sequence 95907 from Patent EP1572962.
JD189110 - Sequence 170134 from Patent EP1572962.
JD438265 - Sequence 419289 from Patent EP1572962.
JD174571 - Sequence 155595 from Patent EP1572962.
JD402405 - Sequence 383429 from Patent EP1572962.
KJ906022 - Synthetic construct Homo sapiens clone ccsbBroadEn_15692 SCAMP3 gene, encodes complete protein.
KJ898149 - Synthetic construct Homo sapiens clone ccsbBroadEn_07543 SCAMP3 gene, encodes complete protein.
CR541757 - Homo sapiens full open reading frame cDNA clone RZPDo834E1229D for gene SCAMP3, secretory carrier membrane protein 3; complete cds, without stopcodon.
KJ901057 - Synthetic construct Homo sapiens clone ccsbBroadEn_10451 SCAMP3 gene, encodes complete protein.
LF206174 - JP 2014500723-A/13677: Polycomb-Associated Non-Coding RNAs.
CU675011 - Synthetic construct Homo sapiens gateway clone IMAGE:100017054 5' read SCAMP3 mRNA.
JD212003 - Sequence 193027 from Patent EP1572962.
JD336871 - Sequence 317895 from Patent EP1572962.
MA441751 - JP 2018138019-A/13677: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A9Z1W6, B1AVS6, C1orf3, ENST00000302631.1, ENST00000302631.2, ENST00000302631.3, ENST00000302631.4, ENST00000302631.5, ENST00000302631.6, ENST00000302631.7, NM_005698, O14828, O15128, PROPIN1, Q96FR8, Q9BPY0, SCAM3_HUMAN, uc317ncb.1, uc317ncb.2
UCSC ID: ENST00000302631.8_7
RefSeq Accession: NM_005698.4
Protein: O14828 (aka SCAM3_HUMAN or SCA3_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.