ID:SCRB2_HUMAN DESCRIPTION: RecName: Full=Lysosome membrane protein 2; AltName: Full=85 kDa lysosomal membrane sialoglycoprotein; Short=LGP85; AltName: Full=CD36 antigen-like 2; AltName: Full=Lysosome membrane protein II; Short=LIMP II; AltName: Full=Scavenger receptor class B member 2; AltName: CD_antigen=CD36; FUNCTION: Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting. SUBUNIT: Interacts with GBA (via the coiled-coil domain). INTERACTION: P17439:Gba (xeno); NbExp=1; IntAct=EBI-1564650, EBI-1564504; SUBCELLULAR LOCATION: Lysosome membrane; Multi-pass membrane protein. MASS SPECTROMETRY: Mass=54158.97; Method=MALDI; Range=2-478; Source=PubMed:11840567; DISEASE: Defects in SCARB2 are the cause of progressive myoclonic epilepsy type 4 with or without renal failure (EPM4) [MIM:254900]. An autosomal recessive progressive myoclonic epilepsy associated with renal failure in some cases. Cognitive function is preserved. Myoclonus is a brief, involuntary twitching of a muscle or a group of muscles. Cognitive function is preserved. DISEASE: Note=Genetic variants in SCARB2 can act as modifier of the phenotypic expression and severity of Gaucher disease. SIMILARITY: Belongs to the CD36 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q14108
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001508 action potential GO:0002532 production of molecular mediator involved in inflammatory response GO:0006622 protein targeting to lysosome GO:0006631 fatty acid metabolic process GO:0006898 receptor-mediated endocytosis GO:0006911 phagocytosis, engulfment GO:0007165 signal transduction GO:0010976 positive regulation of neuron projection development GO:0016032 viral process GO:0031664 regulation of lipopolysaccharide-mediated signaling pathway GO:0046718 viral entry into host cell GO:0061024 membrane organization GO:1904978 regulation of endosome organization GO:1905123 regulation of glucosylceramidase activity GO:1905671 regulation of lysosome organization
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
