Human Gene SEC62 (ENST00000337002.9_4) from GENCODE V48lift37
  Description: SEC62 homolog, preprotein translocation factor (from RefSeq NM_003262.4)
Gencode Transcript: ENST00000337002.9_4
Gencode Gene: ENSG00000008952.17_7
Transcript (Including UTRs)
   Position: hg19 chr3:169,684,595-169,716,161 Size: 31,567 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg19 chr3:169,684,611-169,710,851 Size: 26,241 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2025-04-10 15:10:12

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:169,684,595-169,716,161)mRNA (may differ from genome)Protein (399 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
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MGIneXtProtOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: SEC62_HUMAN
DESCRIPTION: RecName: Full=Translocation protein SEC62; AltName: Full=Translocation protein 1; Short=TP-1; Short=hTP-1;
FUNCTION: Required for preprotein translocation (By similarity).
SUBUNIT: Part of a complex that contains SEC61, SEC62 and SEC63. Interacts with SEC61B.
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity).
SIMILARITY: Belongs to the SEC62 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 34.43 RPKM in Brain - Substantia nigra
Total median expression: 1011.34 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -5.1016-0.319 Picture PostScript Text
3' UTR -1328.905310-0.250 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004728 - Sec62
IPR011991 - WHTH_trsnscrt_rep_DNA-bd

Pfam Domains:
PF03839 - Translocation protein Sec62

SCOP Domains:
46785 - "Winged helix" DNA-binding domain

ModBase Predicted Comparative 3D Structure on Q99442
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0038023 signaling receptor activity

Biological Process:
GO:0006613 cotranslational protein targeting to membrane
GO:0006620 posttranslational protein targeting to membrane
GO:0007165 signal transduction
GO:0015031 protein transport

Cellular Component:
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005791 rough endoplasmic reticulum
GO:0005829 cytosol
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030176 integral component of endoplasmic reticulum membrane


-  Descriptions from all associated GenBank mRNAs
  LP895453 - Sequence 317 from Patent EP3253886.
BC003677 - Homo sapiens SEC62 homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:3932691), partial cds.
BC007040 - Homo sapiens translocation protein 1, mRNA (cDNA clone IMAGE:4051378).
AK294504 - Homo sapiens cDNA FLJ57721 complete cds, highly similar to Translocation protein SEC62.
JD169950 - Sequence 150974 from Patent EP1572962.
BC012035 - Homo sapiens SEC62 homolog (S. cerevisiae), mRNA (cDNA clone MGC:21260 IMAGE:4706586), complete cds.
BX648539 - Homo sapiens mRNA; cDNA DKFZp779P0521 (from clone DKFZp779P0521).
U93239 - Human Sec62 (Sec62) mRNA, complete cds.
D87127 - Homo sapiens mRNA for translocation protein-1, complete cds.
EU832386 - Synthetic construct Homo sapiens clone HAIB:100067415; DKFZo004C0528 translocation protein 1 protein (TLOC1) gene, encodes complete protein.
EU832302 - Synthetic construct Homo sapiens clone HAIB:100067331; DKFZo008C0527 translocation protein 1 protein (TLOC1) gene, encodes complete protein.
KC005990 - Homo sapiens SEC62 splice variant mRNA, complete cds.
BX537668 - Homo sapiens mRNA; cDNA DKFZp686H01109 (from clone DKFZp686H01109).
BC105971 - Homo sapiens SEC62 homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:4475515), partial cds.
JD147219 - Sequence 128243 from Patent EP1572962.
JD279744 - Sequence 260768 from Patent EP1572962.
JD047388 - Sequence 28412 from Patent EP1572962.
JD440215 - Sequence 421239 from Patent EP1572962.
JD167976 - Sequence 149000 from Patent EP1572962.
JD311398 - Sequence 292422 from Patent EP1572962.
JD355706 - Sequence 336730 from Patent EP1572962.
JD077806 - Sequence 58830 from Patent EP1572962.
JD345038 - Sequence 326062 from Patent EP1572962.
JD504962 - Sequence 485986 from Patent EP1572962.
JD053153 - Sequence 34177 from Patent EP1572962.
JD036476 - Sequence 17500 from Patent EP1572962.
JD285062 - Sequence 266086 from Patent EP1572962.
JD248105 - Sequence 229129 from Patent EP1572962.
JD311379 - Sequence 292403 from Patent EP1572962.
JD113520 - Sequence 94544 from Patent EP1572962.
AK025548 - Homo sapiens cDNA: FLJ21895 fis, clone HEP03439.
AK057365 - Homo sapiens cDNA FLJ32803 fis, clone TESTI2002632.
BC089399 - Homo sapiens cDNA clone IMAGE:3055786.
JD411764 - Sequence 392788 from Patent EP1572962.
JD110066 - Sequence 91090 from Patent EP1572962.
JD302813 - Sequence 283837 from Patent EP1572962.
JD504051 - Sequence 485075 from Patent EP1572962.
JD434783 - Sequence 415807 from Patent EP1572962.
JD528563 - Sequence 509587 from Patent EP1572962.
JD330203 - Sequence 311227 from Patent EP1572962.
JD435401 - Sequence 416425 from Patent EP1572962.
JD254566 - Sequence 235590 from Patent EP1572962.
JD508223 - Sequence 489247 from Patent EP1572962.
JD362821 - Sequence 343845 from Patent EP1572962.
JD288547 - Sequence 269571 from Patent EP1572962.
JD410916 - Sequence 391940 from Patent EP1572962.
JD339285 - Sequence 320309 from Patent EP1572962.
JD146623 - Sequence 127647 from Patent EP1572962.
JD284951 - Sequence 265975 from Patent EP1572962.
JD112651 - Sequence 93675 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q99442 (Reactome details) participates in the following event(s):

R-HSA-5250579 ASNA1 transports TA proteins from cytosol to ER membrane
R-HSA-381038 XBP1(S) activates chaperone genes
R-HSA-381070 IRE1alpha activates chaperones
R-HSA-381119 Unfolded Protein Response (UPR)
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: D3DNQ0, ENST00000337002.1, ENST00000337002.2, ENST00000337002.3, ENST00000337002.4, ENST00000337002.5, ENST00000337002.6, ENST00000337002.7, ENST00000337002.8, NM_003262, O00682, O00729, Q99442, SEC62_HUMAN, TLOC1, uc317ure.1, uc317ure.2
UCSC ID: ENST00000337002.9_4
RefSeq Accession: NM_003262.4
Protein: Q99442 (aka SEC62_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.