Human Gene SERTAD3 (ENST00000322354.4_8) from GENCODE V47lift37
  Description: SERTA domain containing 3, transcript variant 2 (from RefSeq NM_203344.3)
Gencode Transcript: ENST00000322354.4_8
Gencode Gene: ENSG00000167565.13_13
Transcript (Including UTRs)
   Position: hg19 chr19:40,946,751-40,950,242 Size: 3,492 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chr19:40,947,397-40,947,987 Size: 591 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:40,946,751-40,950,242)mRNA (may differ from genome)Protein (196 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: SRTD3_HUMAN
DESCRIPTION: RecName: Full=SERTA domain-containing protein 3; AltName: Full=Replication protein-binding trans-activator; Short=RPA-binding trans-activator;
FUNCTION: Strong transcriptional coactivator.
SUBUNIT: Interacts with RPA2.
INTERACTION: Q8N6Y0:USHBP1; NbExp=4; IntAct=EBI-748621, EBI-739895;
SUBCELLULAR LOCATION: Nucleus.
SIMILARITY: Contains 1 SERTA domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: SERTAD3
Diseases sorted by gene-association score: amyotrophic lateral sclerosis 1 (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 15.11 RPKM in Fallopian Tube
Total median expression: 449.27 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -53.30127-0.420 Picture PostScript Text
3' UTR -203.80646-0.315 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009263 - SERTA

Pfam Domains:
PF06031 - SERTA motif

ModBase Predicted Comparative 3D Structure on Q9UJW9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0030308 negative regulation of cell growth
GO:0045893 positive regulation of transcription, DNA-templated

Cellular Component:
GO:0005634 nucleus
GO:0005730 nucleolus


-  Descriptions from all associated GenBank mRNAs
  AF192529 - Homo sapiens RPA-binding trans-activator (RBT1) mRNA, complete cds.
BC050643 - Homo sapiens SERTA domain containing 3, mRNA (cDNA clone MGC:60134 IMAGE:6503515), complete cds.
BC014061 - Homo sapiens SERTA domain containing 3, mRNA (cDNA clone MGC:19994 IMAGE:3926937), complete cds.
AK074604 - Homo sapiens cDNA FLJ90123 fis, clone HEMBA1007226, highly similar to SERTA domain-containing protein 3.
JD254189 - Sequence 235213 from Patent EP1572962.
JD041520 - Sequence 22544 from Patent EP1572962.
JD425724 - Sequence 406748 from Patent EP1572962.
KJ898750 - Synthetic construct Homo sapiens clone ccsbBroadEn_08144 SERTAD3 gene, encodes complete protein.
DL491723 - Novel nucleic acids.
DL490303 - Novel nucleic acids.

-  Other Names for This Gene
  Alternate Gene Symbols: B3KQB3, ENST00000322354.1, ENST00000322354.2, ENST00000322354.3, NM_203344, Q96CQ2, Q9UJW9, RBT1, SRTD3_HUMAN, uc317rgw.1, uc317rgw.2
UCSC ID: ENST00000322354.4_8
RefSeq Accession: NM_203344.3
Protein: Q9UJW9 (aka SRTD3_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.