ID:SOCS4_HUMAN DESCRIPTION: RecName: Full=Suppressor of cytokine signaling 4; Short=SOCS-4; AltName: Full=Suppressor of cytokine signaling 7; Short=SOCS-7; FUNCTION: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. PATHWAY: Protein modification; protein ubiquitination. INDUCTION: Up-regulated by EGF. DOMAIN: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity). SIMILARITY: Contains 1 SH2 domain. SIMILARITY: Contains 1 SOCS box domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8WXH5
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004860 protein kinase inhibitor activity GO:0005515 protein binding
Biological Process: GO:0007175 negative regulation of epidermal growth factor-activated receptor activity GO:0009968 negative regulation of signal transduction GO:0016567 protein ubiquitination GO:0019221 cytokine-mediated signaling pathway GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0035556 intracellular signal transduction GO:0040008 regulation of growth GO:0046426 negative regulation of JAK-STAT cascade
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
