Human Gene SPRR2E (ENST00000368750.8_7) from GENCODE V47lift37
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 Sequence and Links to Tools and Databases
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Comments and Description Text from UniProtKB
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ID: SPR2E_HUMAN
DESCRIPTION: RecName: Full=Small proline-rich protein 2E; Short=SPR-2E; AltName: Full=Small proline-rich protein II; Short=SPR-II;
FUNCTION: Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. SUBCELLULAR LOCATION: Cytoplasm. INDUCTION: During squamous differentiation of epidermal keratinocytes. SIMILARITY: Belongs to the cornifin (SPRR) family.
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 Primer design for this transcript
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 Comparative Toxicogenomics Database (CTD)
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The following chemicals interact with this gene
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 Common Gene Haplotype Alleles
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Press "+" in the title bar above to open this section.
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 RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
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 mRNA Secondary Structure of 3' and 5' UTRs
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The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
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 Protein Domain and Structure Information
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InterPro Domains: Graphical view of domain structure IPR026075 - SPRR/LCE
Pfam Domains: PF14820 - Small proline-rich 2
ModBase Predicted Comparative 3D Structure on P22531
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
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 Orthologous Genes in Other Species
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Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse | Rat | Zebrafish | D. melanogaster | C. elegans | S. cerevisiae |
No ortholog | No ortholog | No ortholog | No ortholog | No ortholog | No ortholog |
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 Gene Ontology (GO) Annotations with Structured Vocabulary
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 Descriptions from all associated GenBank mRNAs
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M20030 - Human small proline rich protein (sprII) mRNA, clone 930. BC058018 - Homo sapiens small proline-rich protein 2E, mRNA (cDNA clone IMAGE:6653118). BC153136 - Synthetic construct Homo sapiens clone IMAGE:100016448, MGC:184316 small proline-rich protein 2E (SPRR2E) mRNA, encodes complete protein. BC148548 - Synthetic construct Homo sapiens clone IMAGE:100015475, MGC:183052 small proline-rich protein 2E (SPRR2E) mRNA, encodes complete protein.
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 Biochemical and Signaling Pathways
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 Other Names for This Gene
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Alternate Gene Symbols: ENST00000368750.1, ENST00000368750.2, ENST00000368750.3, ENST00000368750.4, ENST00000368750.5, ENST00000368750.6, ENST00000368750.7, NM_001024209, P22531, Q5T9T4, Q96RM2, SPR2E_HUMAN, uc318hao.1, uc318hao.2 UCSC ID: ENST00000368750.8_7 RefSeq Accession: NM_001024209.4
Protein: P22531
(aka SPR2E_HUMAN or SP2E_HUMAN)
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 Gene Model Information
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Click here
for a detailed description of the fields of the table above.
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 Methods, Credits, and Use Restrictions
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Click here
for details on how this gene model was made and data restrictions if any.
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