ID:SRPR_HUMAN DESCRIPTION: RecName: Full=Signal recognition particle receptor subunit alpha; Short=SR-alpha; AltName: Full=Docking protein alpha; Short=DP-alpha; FUNCTION: Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. SUBUNIT: Heterodimer with SRPRB. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Thought to be anchored in the membrane through an interaction with SR-beta, which contains a bona fide transmembrane domain. SIMILARITY: Belongs to the GTP-binding SRP family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P08240
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006613 cotranslational protein targeting to membrane GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0006886 intracellular protein transport GO:0036498 IRE1-mediated unfolded protein response
Cellular Component: GO:0005783 endoplasmic reticulum GO:0005785 signal recognition particle receptor complex GO:0005789 endoplasmic reticulum membrane GO:0016020 membrane GO:0016021 integral component of membrane GO:0070062 extracellular exosome
Descriptions from all associated GenBank mRNAs
BC009110 - Homo sapiens signal recognition particle receptor (docking protein), mRNA (cDNA clone MGC:17355 IMAGE:3453825), complete cds. BC008077 - Homo sapiens signal recognition particle receptor ('docking protein'), mRNA (cDNA clone IMAGE:2963671). AK130382 - Homo sapiens cDNA FLJ26872 fis, clone PRS08796, highly similar to Signal recognition particle receptor alpha subunit. BC001162 - Homo sapiens signal recognition particle receptor (docking protein), mRNA (cDNA clone MGC:1609 IMAGE:3528505), complete cds. X06272 - Human mRNA for docking protein (signal recognition particle receptor). BC013583 - Homo sapiens signal recognition particle receptor (docking protein), mRNA (cDNA clone MGC:9571 IMAGE:3877676), complete cds. JD264362 - Sequence 245386 from Patent EP1572962. JD382092 - Sequence 363116 from Patent EP1572962. JD429960 - Sequence 410984 from Patent EP1572962. JD234002 - Sequence 215026 from Patent EP1572962. JD305196 - Sequence 286220 from Patent EP1572962. JD309815 - Sequence 290839 from Patent EP1572962. JD379464 - Sequence 360488 from Patent EP1572962. JD449045 - Sequence 430069 from Patent EP1572962. JD411009 - Sequence 392033 from Patent EP1572962. JD274105 - Sequence 255129 from Patent EP1572962. JD253079 - Sequence 234103 from Patent EP1572962. JD372747 - Sequence 353771 from Patent EP1572962. AK303379 - Homo sapiens cDNA FLJ53386 complete cds, highly similar to Signal recognition particle receptor subunit alpha. JD316814 - Sequence 297838 from Patent EP1572962. JD418384 - Sequence 399408 from Patent EP1572962. JD345180 - Sequence 326204 from Patent EP1572962. JD225734 - Sequence 206758 from Patent EP1572962. JD095401 - Sequence 76425 from Patent EP1572962. CR457025 - Homo sapiens full open reading frame cDNA clone RZPDo834A0121D for gene SRPR, signal recognition particle receptor ('docking protein'); complete cds, incl. stopcodon. AK312377 - Homo sapiens cDNA, FLJ92703, Homo sapiens signal recognition particle receptor ('dockingprotein') (SRPR), mRNA. KJ892201 - Synthetic construct Homo sapiens clone ccsbBroadEn_01595 SRPR gene, encodes complete protein. DQ891476 - Synthetic construct clone IMAGE:100004106; FLH177318.01X; RZPDo839G03124D signal recognition particle receptor ('docking protein') (SRPR) gene, encodes complete protein. DQ894664 - Synthetic construct Homo sapiens clone IMAGE:100009124; FLH177315.01L; RZPDo839G03123D signal recognition particle receptor ('docking protein') (SRPR) gene, encodes complete protein. AB385045 - Synthetic construct DNA, clone: pF1KB5110, Homo sapiens SRPR gene for signal recognition particle receptor subunit alpha, complete cds, without stop codon, in Flexi system. KJ901764 - Synthetic construct Homo sapiens clone ccsbBroadEn_11158 SRPR gene, encodes complete protein. DL492496 - Novel nucleic acids. DL490966 - Novel nucleic acids.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P08240 (Reactome details) participates in the following event(s):
R-HSA-1799330 The SRP receptor binds the SRP:nascent peptide:ribosome complex R-HSA-1799326 Signal-containing nascent peptide translocates to endoplasmic reticulum R-HSA-381038 XBP1(S) activates chaperone genes R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane R-HSA-381070 IRE1alpha activates chaperones R-HSA-72766 Translation R-HSA-381119 Unfolded Protein Response (UPR) R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
