ID:STEA3_HUMAN DESCRIPTION: RecName: Full=Metalloreductase STEAP3; EC=1.16.1.-; AltName: Full=Dudulin-2; AltName: Full=Six-transmembrane epithelial antigen of prostate 3; AltName: Full=Tumor suppressor-activated pathway protein 6; Short=hTSAP6; AltName: Full=pHyde; Short=hpHyde; FUNCTION: Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP. COFACTOR: FAD (By similarity). COFACTOR: NADP. SUBUNIT: Homodimer. Interacts with BNIP3L, MYT1, RHBDL4/RHBDD1 and TCTP. SUBCELLULAR LOCATION: Endosome membrane; Multi-pass membrane protein (By similarity). Note=Localizes to vesicular-like structures at the plasma membrane and around the nucleus. TISSUE SPECIFICITY: Expressed in adult bone marrow, placenta, liver, skeletal muscle and pancreas. Down-regulated in hepatocellular carcinoma. INDUCTION: By p53/TP53. PTM: Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1- induced cleavage occurs at multiple sites in a glycosylation- independent manner. PTM: Glycosylated. SIMILARITY: Belongs to the STEAP family. SIMILARITY: Contains 1 ferric oxidoreductase domain. CAUTION: Was initially thought to have tumor suppressor function in prostate cancer. However, it was shown that it is probably not the case (PubMed:12866033).
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q658P3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0008823 cupric reductase activity GO:0016491 oxidoreductase activity GO:0016723 oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor GO:0042802 identical protein binding GO:0046872 metal ion binding GO:0052851 ferric-chelate reductase (NADPH) activity
AL833624 - Homo sapiens mRNA; cDNA DKFZp686K0573 (from clone DKFZp686K0573). AY029585 - Homo sapiens dudulin 2 mRNA, complete cds. AF423424 - Homo sapiens six transmembrane prostate protein 3 mRNA, complete cds. AK001691 - Homo sapiens cDNA FLJ10829 fis, clone NT2RP4001138. AY214461 - Homo sapiens TSAP6 mRNA, complete cds. BX538047 - Homo sapiens mRNA; cDNA DKFZp686H07150 (from clone DKFZp686H07150). AK291608 - Homo sapiens cDNA FLJ77562 complete cds, highly similar to Homo sapiens STEAP family member 3 (STEAP3), transcript variant 1, mRNA. AF238864 - Homo sapiens tumor suppressor pHyde mRNA, complete cds. AF262322 - Homo sapiens pHYDE II mRNA, complete cds. AY082673 - Homo sapiens pHyde mRNA, complete cds. BC095421 - Homo sapiens STEAP family member 3, mRNA (cDNA clone MGC:110951 IMAGE:30336214), complete cds. JD422378 - Sequence 403402 from Patent EP1572962. BC042150 - Homo sapiens STEAP family member 3, mRNA (cDNA clone MGC:52186 IMAGE:4586693), complete cds. CU692068 - Synthetic construct Homo sapiens gateway clone IMAGE:100022468 5' read STEAP3 mRNA. AM392543 - Synthetic construct Homo sapiens clone IMAGE:100002982 for hypothetical protein (STEAP3 gene). KJ906219 - Synthetic construct Homo sapiens clone ccsbBroadEn_15889 STEAP3 gene, encodes complete protein. AK024163 - Homo sapiens cDNA FLJ14101 fis, clone MAMMA1000859. JD563975 - Sequence 544999 from Patent EP1572962. JD089947 - Sequence 70971 from Patent EP1572962. JD224651 - Sequence 205675 from Patent EP1572962. JD495367 - Sequence 476391 from Patent EP1572962. JD261810 - Sequence 242834 from Patent EP1572962. JD400540 - Sequence 381564 from Patent EP1572962. JD483205 - Sequence 464229 from Patent EP1572962. JD434119 - Sequence 415143 from Patent EP1572962. JD080023 - Sequence 61047 from Patent EP1572962. JD227829 - Sequence 208853 from Patent EP1572962. JD472850 - Sequence 453874 from Patent EP1572962. JD092759 - Sequence 73783 from Patent EP1572962. JD310888 - Sequence 291912 from Patent EP1572962. JD110358 - Sequence 91382 from Patent EP1572962. JD280203 - Sequence 261227 from Patent EP1572962. JD159560 - Sequence 140584 from Patent EP1572962. JD056684 - Sequence 37708 from Patent EP1572962. JD439913 - Sequence 420937 from Patent EP1572962. JD392856 - Sequence 373880 from Patent EP1572962. JD492761 - Sequence 473785 from Patent EP1572962. JD515763 - Sequence 496787 from Patent EP1572962. JD470458 - Sequence 451482 from Patent EP1572962. JD303752 - Sequence 284776 from Patent EP1572962. JD367996 - Sequence 349020 from Patent EP1572962. JD115356 - Sequence 96380 from Patent EP1572962. JD310640 - Sequence 291664 from Patent EP1572962. JD064797 - Sequence 45821 from Patent EP1572962. JD395924 - Sequence 376948 from Patent EP1572962. JD216254 - Sequence 197278 from Patent EP1572962. JD513072 - Sequence 494096 from Patent EP1572962. JD521730 - Sequence 502754 from Patent EP1572962. JD272616 - Sequence 253640 from Patent EP1572962. JD253704 - Sequence 234728 from Patent EP1572962. JD063565 - Sequence 44589 from Patent EP1572962. JD260537 - Sequence 241561 from Patent EP1572962. JD267984 - Sequence 249008 from Patent EP1572962. JD449620 - Sequence 430644 from Patent EP1572962. JD216422 - Sequence 197446 from Patent EP1572962. JD512968 - Sequence 493992 from Patent EP1572962. JD124711 - Sequence 105735 from Patent EP1572962. JD261359 - Sequence 242383 from Patent EP1572962. JD103731 - Sequence 84755 from Patent EP1572962. JD062742 - Sequence 43766 from Patent EP1572962. JD204974 - Sequence 185998 from Patent EP1572962. JD185972 - Sequence 166996 from Patent EP1572962. JD252054 - Sequence 233078 from Patent EP1572962. JD046050 - Sequence 27074 from Patent EP1572962. JD342755 - Sequence 323779 from Patent EP1572962. JD323755 - Sequence 304779 from Patent EP1572962. JD404332 - Sequence 385356 from Patent EP1572962. JD519245 - Sequence 500269 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q658P3 (Reactome details) participates in the following event(s):
R-HSA-6801195 STEAP3 binds BNIP3L R-HSA-917811 STEAP3-like proteins reduce Fe3+ to Fe2+ R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes R-HSA-917977 Transferrin endocytosis and recycling R-HSA-3700989 Transcriptional Regulation by TP53 R-HSA-917937 Iron uptake and transport R-HSA-212436 Generic Transcription Pathway R-HSA-382551 Transport of small molecules R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription)
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
