Human Gene STX2 (ENST00000392373.7_11) from GENCODE V47lift37
  Description: syntaxin 2, transcript variant 2 (from RefSeq NM_194356.4)
Gencode Transcript: ENST00000392373.7_11
Gencode Gene: ENSG00000111450.15_16
Transcript (Including UTRs)
   Position: hg19 chr12:131,274,145-131,323,795 Size: 49,651 Total Exon Count: 11 Strand: -
Coding Region
   Position: hg19 chr12:131,280,585-131,323,644 Size: 43,060 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:131,274,145-131,323,795)mRNA (may differ from genome)Protein (288 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: STX2_HUMAN
DESCRIPTION: RecName: Full=Syntaxin-2; AltName: Full=Epimorphin;
FUNCTION: Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm.
SUBUNIT: Interacts with SYT6 and SYT8; the interaction is Ca(2+)- dependent (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type IV membrane protein.
SIMILARITY: Belongs to the syntaxin family.
SIMILARITY: Contains 1 t-SNARE coiled-coil homology domain.
SEQUENCE CAUTION: Sequence=BAA03436.1; Type=Frameshift; Positions=Several;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: STX2
Diseases sorted by gene-association score: osteogenesis imperfecta, type xv (3), deafness, autosomal dominant 41 (3), deafness, autosomal dominant 25 (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 18.34 RPKM in Cells - Cultured fibroblasts
Total median expression: 477.46 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -87.80151-0.581 Picture PostScript Text
3' UTR -646.302423-0.267 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006012 - Syntaxin/epimorphin_CS
IPR006011 - Syntaxin_N
IPR010989 - t-SNARE
IPR000727 - T_SNARE_dom

Pfam Domains:
PF00804 - Syntaxin
PF05739 - SNARE domain
PF14523 - Syntaxin-like protein

SCOP Domains:
47162 - Apolipoprotein
47661 - t-snare proteins
46966 - Spectrin repeat
55186 - ThrRS/AlaRS common domain
58038 - SNARE fusion complex
75708 - Chemotaxis phosphatase CheZ
58104 - Methyl-accepting chemotaxis protein (MCP) signaling domain

ModBase Predicted Comparative 3D Structure on P32856
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000149 SNARE binding
GO:0005484 SNAP receptor activity
GO:0005515 protein binding
GO:0046983 protein dimerization activity
GO:0048306 calcium-dependent protein binding

Biological Process:
GO:0006886 intracellular protein transport
GO:0007165 signal transduction
GO:0007340 acrosome reaction
GO:0007398 ectoderm development
GO:0009887 animal organ morphogenesis
GO:0016192 vesicle-mediated transport
GO:0030154 cell differentiation
GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane
GO:0033194 response to hydroperoxide
GO:0048278 vesicle docking
GO:0051259 protein oligomerization
GO:1903575 cornified envelope assembly

Cellular Component:
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0008021 synaptic vesicle
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0030027 lamellipodium
GO:0031201 SNARE complex
GO:0043231 intracellular membrane-bounded organelle


-  Descriptions from all associated GenBank mRNAs
  BC047496 - Homo sapiens syntaxin 2, mRNA (cDNA clone MGC:51014 IMAGE:5296500), complete cds.
LF384030 - JP 2014500723-A/191533: Polycomb-Associated Non-Coding RNAs.
AF052181 - Homo sapiens clone 24790 mRNA sequence.
JD505482 - Sequence 486506 from Patent EP1572962.
JD346452 - Sequence 327476 from Patent EP1572962.
JD225343 - Sequence 206367 from Patent EP1572962.
JD345630 - Sequence 326654 from Patent EP1572962.
JD533854 - Sequence 514878 from Patent EP1572962.
D14582 - Homo sapiens mRNA for epimorphin, complete cds.
E06628 - cDNA encoding isoform B of human epimorphin.
E08285 - cDNA encoding isoform B of epimorphine.
E06627 - cDNA encoding isoform A of human epimorphin.
E08284 - cDNA encoding isoform A of epimorphine.
KJ896777 - Synthetic construct Homo sapiens clone ccsbBroadEn_06171 STX2 gene, encodes complete protein.
E06626 - cDNA encoding human epimorphin.
E08283 - cDNA encoding epimorphine.
LF359758 - JP 2014500723-A/167261: Polycomb-Associated Non-Coding RNAs.
LF359760 - JP 2014500723-A/167263: Polycomb-Associated Non-Coding RNAs.
JD484810 - Sequence 465834 from Patent EP1572962.
MA619607 - JP 2018138019-A/191533: Polycomb-Associated Non-Coding RNAs.
MA595335 - JP 2018138019-A/167261: Polycomb-Associated Non-Coding RNAs.
MA595337 - JP 2018138019-A/167263: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000392373.1, ENST00000392373.2, ENST00000392373.3, ENST00000392373.4, ENST00000392373.5, ENST00000392373.6, EPIM, NM_194356, P32856, Q86VW8, STX2A, STX2B, STX2C, STX2_HUMAN, uc318vat.1, uc318vat.2
UCSC ID: ENST00000392373.7_11
RefSeq Accession: NM_194356.4
Protein: P32856 (aka STX2_HUMAN or EPMO_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.