ID:SYT8_HUMAN DESCRIPTION: RecName: Full=Synaptotagmin-8; AltName: Full=Synaptotagmin VIII; Short=SytVIII; FUNCTION: Isoform 4 may play a role in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Mediates Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. May mediate Ca(2+)-regulation of exocytosis in insulin secreted cells (By similarity). SUBUNIT: Homodimer or homooligomer. Homodimerization and homooligomerization do not depend on Ca(2+). Interacts with SYNCRIP isoform 2 C-terminus. Binds inositol 1,3,4,5- tetrakisphosphate (IP4). Binds to AP2 in a Ca(2+)-independent manner. Interacts with STX1A, STX1B and STX2; the interaction is Ca(2+)-dependent (By similarity). SUBCELLULAR LOCATION: Cell membrane; Single-pass type III membrane protein (By similarity). Cytoplasmic vesicle, secretory vesicle, acrosome (By similarity). DOMAIN: The first C2 domain/C2A does not mediate Ca(2+)-dependent phospholipid binding (By similarity). DOMAIN: The second C2 domain/C2B is responsible for SYNCRIP and inositol 1,3,4,5-tetrakisphosphate (IP4)-binding (By similarity). SIMILARITY: Belongs to the synaptotagmin family. SIMILARITY: Contains 2 C2 domains. SEQUENCE CAUTION: Sequence=AAQ57209.1; Type=Miscellaneous discrepancy; Note=May be due to an intron retention; Sequence=CAB70885.2; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown because it is a pre-mRNA;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8NBV8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
