ID:TAL1_HUMAN DESCRIPTION: RecName: Full=T-cell acute lymphocytic leukemia protein 1; Short=TAL-1; AltName: Full=Class A basic helix-loop-helix protein 17; Short=bHLHa17; AltName: Full=Stem cell protein; AltName: Full=T-cell leukemia/lymphoma protein 5; FUNCTION: Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity). SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein. Forms heterodimers with TCF3. Binds to the LIM domain containing protein LMO2 and to DRG1. Can assemble in a complex with LDB1 and LMO2. Component of a TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3 (By similarity). INTERACTION: P25801:Lmo2 (xeno); NbExp=5; IntAct=EBI-1753878, EBI-3903256; P15923:TCF3; NbExp=4; IntAct=EBI-1753878, EBI-769630; SUBCELLULAR LOCATION: Nucleus (By similarity). TISSUE SPECIFICITY: Leukemic stem cell. DOMAIN: The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1. PTM: Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia (By similarity). PTM: Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it could not be observed in large vessel endothelial cells (By similarity). DISEASE: Note=A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes. SIMILARITY: Contains 1 bHLH (basic helix-loop-helix) domain. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/TAL1.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P17542
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000976 transcription regulatory region sequence-specific DNA binding GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001085 RNA polymerase II transcription factor binding GO:0003677 DNA binding GO:0003682 chromatin binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0019899 enzyme binding GO:0042826 histone deacetylase binding GO:0044212 transcription regulatory region DNA binding GO:0046982 protein heterodimerization activity GO:0046983 protein dimerization activity GO:0070888 E-box binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0001525 angiogenesis GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0007275 multicellular organism development GO:0007626 locomotory behavior GO:0021527 spinal cord association neuron differentiation GO:0030097 hemopoiesis GO:0030099 myeloid cell differentiation GO:0030154 cell differentiation GO:0030182 neuron differentiation GO:0030218 erythrocyte differentiation GO:0030219 megakaryocyte differentiation GO:0030220 platelet formation GO:0030221 basophil differentiation GO:0031334 positive regulation of protein complex assembly GO:0035162 embryonic hemopoiesis GO:0035855 megakaryocyte development GO:0042127 regulation of cell proliferation GO:0043249 erythrocyte maturation GO:0045165 cell fate commitment GO:0045637 regulation of myeloid cell differentiation GO:0045648 positive regulation of erythrocyte differentiation GO:0045799 positive regulation of chromatin assembly or disassembly GO:0045893 positive regulation of transcription, DNA-templated GO:0045931 positive regulation of mitotic cell cycle GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048699 generation of neurons GO:0051781 positive regulation of cell division GO:0060018 astrocyte fate commitment GO:0060216 definitive hemopoiesis GO:0060217 hemangioblast cell differentiation GO:0060218 hematopoietic stem cell differentiation GO:0060375 regulation of mast cell differentiation GO:1902036 regulation of hematopoietic stem cell differentiation GO:2000036 regulation of stem cell population maintenance
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
