ID:BROMI_HUMAN DESCRIPTION: RecName: Full=Protein broad-minded; FUNCTION: Required for high-level Shh responses in the developing neural tube. Together with CDK20, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to Shh signaling (By similarity). SUBUNIT: Interacts with CDK20, which promotes CDK20 stability and function (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell projection, cilium (By similarity). SIMILARITY: Contains 1 Rab-GAP TBC domain. CAUTION: The Rab-GAP TBC domain appears to be inactive, probably due to a lack of the essential Arg and Gln in the catalytic finger motifs. SEQUENCE CAUTION: Sequence=BAB70925.1; Type=Frameshift; Positions=717; Sequence=BAC03694.1; Type=Frameshift; Positions=143; Sequence=BAC03694.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing; Sequence=BAC86152.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAD18591.1; Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=CAI16051.2; Type=Erroneous gene model prediction; Sequence=CAI20000.2; Type=Erroneous gene model prediction; Sequence=CAM16339.1; Type=Erroneous gene model prediction; Sequence=CAM17813.1; Type=Erroneous gene model prediction; Sequence=CAM28224.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 48371 - ARM repeat 47923 - Ypt/Rab-GAP domain of gyp1p
ModBase Predicted Comparative 3D Structure on Q96NH3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
