Human Gene TBXA2R (ENST00000375190.10_7) from GENCODE V47lift37
  Description: thromboxane A2 receptor, transcript variant a (from RefSeq NM_001060.6)
Gencode Transcript: ENST00000375190.10_7
Gencode Gene: ENSG00000006638.13_8
Transcript (Including UTRs)
   Position: hg19 chr19:3,594,505-3,606,873 Size: 12,369 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr19:3,595,686-3,600,632 Size: 4,947 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:3,594,505-3,606,873)mRNA (may differ from genome)Protein (343 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TA2R_HUMAN
DESCRIPTION: RecName: Full=Thromboxane A2 receptor; Short=TXA2-R; AltName: Full=Prostanoid TP receptor;
FUNCTION: Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase.
SUBUNIT: Interacts with RPGRIP1L. Interacts with PSMA3. Interacts with GNB2L1/RACK1; the interaction regulates TBXA2R cell surface expression.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
DISEASE: Defects in TBXA2R are the cause of susceptibility to bleeding disorder platelet-type 13 (BDPLT13) [MIM:614009]. BDPLT13 is a disorder characterized by reduced platelet aggregation and a tendency to mild mucocutaneous bleeding.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
SEQUENCE CAUTION: Sequence=AAA58957.1; Type=Frameshift; Positions=329;
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/tbxa2r/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: TBXA2R
Diseases sorted by gene-association score: bleeding disorder, platelet-type, 13* (1030), stroke, ischemic (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D019796 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
  • C045749 SQ 29548
  • C061750 7-(3-(3-hydroxy-4-(4'-iodophenoxy)-1-butenyl)-7-oxabicyclo(2.2.1)heptan-2-yl)-5-heptenoic acid
  • D002118 Calcium
  • D013749 Tetrachlorodibenzodioxin
  • C063119 ramatroban
  • C097240 15-deoxy-delta(12,14)-prostaglandin J2
  • C075750 8-epi-prostaglandin F2alpha
  • D000082 Acetaminophen
  • D000643 Ammonium Chloride
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 20.74 RPKM in Artery - Aorta
Total median expression: 128.17 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -183.60429-0.428 Picture PostScript Text
3' UTR -445.101181-0.377 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR008365 - Prostanoid_rcpt
IPR001105 - Thbox_rcpt

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1LBN - Model


ModBase Predicted Comparative 3D Structure on P21731
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004960 thromboxane receptor activity
GO:0004961 thromboxane A2 receptor activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding

Biological Process:
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007584 response to nutrient
GO:0019229 regulation of vasoconstriction
GO:0019932 second-messenger-mediated signaling
GO:0030194 positive regulation of blood coagulation
GO:0032496 response to lipopolysaccharide
GO:0033574 response to testosterone
GO:0038193 thromboxane A2 signaling pathway
GO:0042493 response to drug
GO:0045471 response to ethanol
GO:0045766 positive regulation of angiogenesis
GO:0045777 positive regulation of blood pressure
GO:0045907 positive regulation of vasoconstriction
GO:0045987 positive regulation of smooth muscle contraction
GO:0071222 cellular response to lipopolysaccharide
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis

Cellular Component:
GO:0001669 acrosomal vesicle
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016607 nuclear speck


-  Descriptions from all associated GenBank mRNAs
  BC121148 - Homo sapiens thromboxane A2 receptor, mRNA (cDNA clone MGC:150484 IMAGE:40121265), complete cds.
BC121149 - Homo sapiens thromboxane A2 receptor, mRNA (cDNA clone IMAGE:40121267), complete cds.
D38081 - Homo sapiens mRNA for thromboxane A2 receptor, complete cds.
E03829 - cDNA encoding human thromboxane receptor.
U11271 - Human alternatively spliced endothelial thromboxane A2 receptor mRNA, complete cds.
JD346471 - Sequence 327495 from Patent EP1572962.
JD070106 - Sequence 51130 from Patent EP1572962.
JD514084 - Sequence 495108 from Patent EP1572962.
JD414831 - Sequence 395855 from Patent EP1572962.
JD397053 - Sequence 378077 from Patent EP1572962.
JD311806 - Sequence 292830 from Patent EP1572962.
JD311807 - Sequence 292831 from Patent EP1572962.
JD414832 - Sequence 395856 from Patent EP1572962.
JD397054 - Sequence 378078 from Patent EP1572962.
JD476731 - Sequence 457755 from Patent EP1572962.
JD536702 - Sequence 517726 from Patent EP1572962.
JD069740 - Sequence 50764 from Patent EP1572962.
JD321651 - Sequence 302675 from Patent EP1572962.
JD264619 - Sequence 245643 from Patent EP1572962.
JD391338 - Sequence 372362 from Patent EP1572962.
JD055328 - Sequence 36352 from Patent EP1572962.
U27325 - Human thromboxane A2 receptor mRNA, complete cds.
KJ901780 - Synthetic construct Homo sapiens clone ccsbBroadEn_11174 TBXA2R gene, encodes complete protein.
JD485184 - Sequence 466208 from Patent EP1572962.
JD290620 - Sequence 271644 from Patent EP1572962.
JD210466 - Sequence 191490 from Patent EP1572962.
BC074749 - Homo sapiens thromboxane A2 receptor, mRNA (cDNA clone MGC:104015 IMAGE:30915459), complete cds.
BC074750 - Homo sapiens thromboxane A2 receptor, mRNA (cDNA clone MGC:103827 IMAGE:30915209), complete cds.
AY429110 - Homo sapiens thromboxane A2 receptor mRNA, complete cds.
BC028027 - Homo sapiens thromboxane A2 receptor, mRNA (cDNA clone IMAGE:5219219), partial cds.
JD126818 - Sequence 107842 from Patent EP1572962.
JD439621 - Sequence 420645 from Patent EP1572962.
JD405710 - Sequence 386734 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_eicosanoidPathway - Eicosanoid Metabolism

Reactome (by CSHL, EBI, and GO)

Protein P21731 (Reactome details) participates in the following event(s):

R-HSA-391939 TP receptor can bind thromboxane
R-HSA-428752 Dissociation of the TP:Gq complex
R-HSA-428918 Dissociation of the TP:G13 complex
R-HSA-428749 Activated TP receptor binds G-proten Gq
R-HSA-428909 Activated TP receptor binds G-protein G13
R-HSA-749452 The Ligand:GPCR:Gq complex dissociates
R-HSA-751019 The Ligand:GPCR:G12/13 complex dissociates
R-HSA-428750 Gq activation by TP receptor
R-HSA-428917 G13 activation by TP receptor
R-HSA-749448 Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
R-HSA-751027 Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13
R-HSA-379048 Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
R-HSA-751029 Liganded G12/13-activating GPCR acts as a GEF for G12/13
R-HSA-391908 Prostanoid ligand receptors
R-HSA-428930 Thromboxane signalling through TP receptor
R-HSA-416476 G alpha (q) signalling events
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-391903 Eicosanoid ligand-binding receptors
R-HSA-392518 Signal amplification
R-HSA-388396 GPCR downstream signalling
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-372790 Signaling by GPCR
R-HSA-500792 GPCR ligand binding
R-HSA-109582 Hemostasis
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000375190.1, ENST00000375190.2, ENST00000375190.3, ENST00000375190.4, ENST00000375190.5, ENST00000375190.6, ENST00000375190.7, ENST00000375190.8, ENST00000375190.9, NM_001060, O75228, P21731, Q6DK52, Q9UCY1, Q9UCY2, TA2R_HUMAN, uc318mcj.1, uc318mcj.2
UCSC ID: ENST00000375190.10_7
RefSeq Accession: NM_001060.6
Protein: P21731 (aka TA2R_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.