Human Gene TCEAL8 (ENST00000360000.8_5) from GENCODE V47lift37
  Description: transcription elongation factor A like 8, transcript variant 2 (from RefSeq NM_001006684.2)
Gencode Transcript: ENST00000360000.8_5
Gencode Gene: ENSG00000180964.17_9
Transcript (Including UTRs)
   Position: hg19 chrX:102,507,923-102,510,113 Size: 2,191 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chrX:102,508,554-102,508,907 Size: 354 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:102,507,923-102,510,113)mRNA (may differ from genome)Protein (117 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TCAL8_HUMAN
DESCRIPTION: RecName: Full=Transcription elongation factor A protein-like 8; Short=TCEA-like protein 8; AltName: Full=Transcription elongation factor S-II protein-like 8;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Belongs to the TFS-II family. TFA subfamily.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 48.93 RPKM in Cells - Cultured fibroblasts
Total median expression: 1442.47 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -35.70146-0.245 Picture PostScript Text
3' UTR -127.20631-0.202 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR021156 - TF_A-like/BEX-like
IPR010370 - TFA

Pfam Domains:
PF04538 - Brain expressed X-linked like family

ModBase Predicted Comparative 3D Structure on Q8IYN2
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0050699 WW domain binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  LF211669 - JP 2014500723-A/19172: Polycomb-Associated Non-Coding RNAs.
AK026349 - Homo sapiens cDNA: FLJ22696 fis, clone HSI11696.
AL833632 - Homo sapiens mRNA; cDNA DKFZp686G0879 (from clone DKFZp686G0879).
BC035573 - Homo sapiens transcription elongation factor A (SII)-like 8, mRNA (cDNA clone MGC:45400 IMAGE:5405281), complete cds.
LF382291 - JP 2014500723-A/189794: Polycomb-Associated Non-Coding RNAs.
JD072810 - Sequence 53834 from Patent EP1572962.
JD043955 - Sequence 24979 from Patent EP1572962.
LF382292 - JP 2014500723-A/189795: Polycomb-Associated Non-Coding RNAs.
JD232641 - Sequence 213665 from Patent EP1572962.
JD285002 - Sequence 266026 from Patent EP1572962.
JD551281 - Sequence 532305 from Patent EP1572962.
JD083583 - Sequence 64607 from Patent EP1572962.
JD283913 - Sequence 264937 from Patent EP1572962.
JD084626 - Sequence 65650 from Patent EP1572962.
JD490706 - Sequence 471730 from Patent EP1572962.
LF382293 - JP 2014500723-A/189796: Polycomb-Associated Non-Coding RNAs.
JD117955 - Sequence 98979 from Patent EP1572962.
JD123782 - Sequence 104806 from Patent EP1572962.
JD283984 - Sequence 265008 from Patent EP1572962.
EU446605 - Synthetic construct Homo sapiens clone IMAGE:100070251; IMAGE:100011814; FLH257285.01L transcription elongation factor A (SII)-like 8 (TCEAL8) gene, encodes complete protein.
KJ899912 - Synthetic construct Homo sapiens clone ccsbBroadEn_09306 TCEAL8 gene, encodes complete protein.
AB464733 - Synthetic construct DNA, clone: pF1KB9799, Homo sapiens TCEAL8 gene for transcription elongation factor A (SII)-like 8, without stop codon, in Flexi system.
LF382294 - JP 2014500723-A/189797: Polycomb-Associated Non-Coding RNAs.
LF382295 - JP 2014500723-A/189798: Polycomb-Associated Non-Coding RNAs.
MA447246 - JP 2018138019-A/19172: Polycomb-Associated Non-Coding RNAs.
MA617868 - JP 2018138019-A/189794: Polycomb-Associated Non-Coding RNAs.
MA617869 - JP 2018138019-A/189795: Polycomb-Associated Non-Coding RNAs.
MA617870 - JP 2018138019-A/189796: Polycomb-Associated Non-Coding RNAs.
MA617871 - JP 2018138019-A/189797: Polycomb-Associated Non-Coding RNAs.
MA617872 - JP 2018138019-A/189798: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000360000.1, ENST00000360000.2, ENST00000360000.3, ENST00000360000.4, ENST00000360000.5, ENST00000360000.6, ENST00000360000.7, NM_001006684, Q8IYN2, TCAL8_HUMAN, uc318bii.1, uc318bii.2
UCSC ID: ENST00000360000.8_5
RefSeq Accession: NM_001006684.2
Protein: Q8IYN2 (aka TCAL8_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.