Human Gene TEX11 (ENST00000374333.7_10) from GENCODE V47lift37
  Description: testis expressed 11, transcript variant 2 (from RefSeq NM_031276.3)
Gencode Transcript: ENST00000374333.7_10
Gencode Gene: ENSG00000120498.14_13
Transcript (Including UTRs)
   Position: hg19 chrX:69,748,790-70,128,561 Size: 379,772 Total Exon Count: 30 Strand: -
Coding Region
   Position: hg19 chrX:69,748,945-70,127,639 Size: 378,695 Coding Exon Count: 29 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:69,748,790-70,128,561)mRNA (may differ from genome)Protein (925 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TEX11_HUMAN
DESCRIPTION: RecName: Full=Testis-expressed sequence 11 protein;
INTERACTION: Q96GY3:LIN37; NbExp=2; IntAct=EBI-742397, EBI-748884; Q96FH0:MEF2BNB; NbExp=2; IntAct=EBI-742397, EBI-744076; Q93045:STMN2; NbExp=2; IntAct=EBI-742397, EBI-714194;
SEQUENCE CAUTION: Sequence=AAK31973.1; Type=Erroneous initiation; Sequence=CAI39958.1; Type=Erroneous initiation; Sequence=CAI40155.1; Type=Erroneous initiation; Sequence=CAI41496.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: TEX11
Diseases sorted by gene-association score: spermatogenic failure, x-linked, 2* (1330), azoospermia (8), male reproductive system disease (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 9.56 RPKM in Testis
Total median expression: 14.69 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -20.3079-0.257 Picture PostScript Text
3' UTR -29.50155-0.190 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013940 - Meiosis_specific_SPO22
IPR011990 - TPR-like_helical

Pfam Domains:
PF08631 - Meiosis protein SPO22/ZIP4 like

SCOP Domains:
81901 - HCP-like
48452 - TPR-like
144059 - ImpE-like

ModBase Predicted Comparative 3D Structure on Q8IYF3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0000712 resolution of meiotic recombination intermediates
GO:0006311 meiotic gene conversion
GO:0007060 male meiosis chromosome segregation
GO:0007130 synaptonemal complex assembly
GO:0007131 reciprocal meiotic recombination
GO:0007140 male meiosis
GO:0008584 male gonad development
GO:0009566 fertilization
GO:0043066 negative regulation of apoptotic process
GO:0051026 chiasma assembly
GO:0051321 meiotic cell cycle

Cellular Component:
GO:0000794 condensed nuclear chromosome
GO:0000795 synaptonemal complex
GO:0000801 central element
GO:0005694 chromosome


-  Descriptions from all associated GenBank mRNAs
  AK057391 - Homo sapiens cDNA FLJ32829 fis, clone TESTI2003130.
AF285594 - Homo sapiens testis protein TEX11 (TEX11) mRNA, complete cds.
AK057523 - Homo sapiens cDNA FLJ32961 fis, clone TESTI2008343.
AK292471 - Homo sapiens cDNA FLJ77608 complete cds, highly similar to Homo sapiens testis expressed sequence 11 (TEX11), transcript variant 2, mRNA.
BC036016 - Homo sapiens testis expressed 11, mRNA (cDNA clone MGC:32951 IMAGE:5270970), complete cds.
EU176265 - Synthetic construct Homo sapiens clone IMAGE:100006377; FLH170471.01X; RZPDo839F0998D testis expressed 11 (TEX11) gene, encodes complete protein.
KJ901068 - Synthetic construct Homo sapiens clone ccsbBroadEn_10462 TEX11 gene, encodes complete protein.
DQ894427 - Synthetic construct Homo sapiens clone IMAGE:100008887; FLH170467.01L; RZPDo839F0997D testis expressed sequence 11 (TEX11) gene, encodes complete protein.
AB529163 - Synthetic construct DNA, clone: pF1KB8505, Homo sapiens TEX11 gene for testis expressed 11, without stop codon, in Flexi system.
JD298712 - Sequence 279736 from Patent EP1572962.
JD361568 - Sequence 342592 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K8V6, ENST00000374333.1, ENST00000374333.2, ENST00000374333.3, ENST00000374333.4, ENST00000374333.5, ENST00000374333.6, NM_031276, Q5JQQ8, Q8IYF3, Q96LZ4, Q96M47, Q9BXU6, TEX11_HUMAN, uc318lmu.1, uc318lmu.2, ZIP4
UCSC ID: ENST00000374333.7_10
RefSeq Accession: NM_031276.3
Protein: Q8IYF3 (aka TEX11_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.