ID:TRFE_HUMAN DESCRIPTION: RecName: Full=Serotransferrin; Short=Transferrin; AltName: Full=Beta-1 metal-binding globulin; AltName: Full=Siderophilin; Flags: Precursor; FUNCTION: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. SUBUNIT: Monomer. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Expressed by the liver and secreted in plasma. POLYMORPHISM: Different polymorphic variants of transferrin are known. The sequence shown is the predominant electrophoretic variant (C1 or TF*C1). DISEASE: Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:209300]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia. SIMILARITY: Belongs to the transferrin family. SIMILARITY: Contains 2 transferrin-like domains. SEQUENCE CAUTION: Sequence=AAF22007.1; Type=Erroneous initiation; Note=Translation N-terminally extended; WEB RESOURCE: Name=Wikipedia; Note=Transferrin entry; URL="http://en.wikipedia.org/wiki/Transferrin"; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/tf/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P02787
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001895 retina homeostasis GO:0002576 platelet degranulation GO:0006811 ion transport GO:0006826 iron ion transport GO:0006879 cellular iron ion homeostasis GO:0031647 regulation of protein stability GO:0033572 transferrin transport GO:0043687 post-translational protein modification GO:0044267 cellular protein metabolic process GO:0048260 positive regulation of receptor-mediated endocytosis GO:0055072 iron ion homeostasis GO:0061024 membrane organization GO:0071281 cellular response to iron ion GO:1900390 regulation of iron ion import
CR936810 - Homo sapiens mRNA; cDNA DKFZp781D0156 (from clone DKFZp781D0156). AJ252279 - Homo sapiens partial mRNA for transferrin (TF gene), alternatively spliced transcript. BC045772 - Homo sapiens cDNA clone IMAGE:5265104, containing frame-shift errors. AK293842 - Homo sapiens cDNA FLJ56687 complete cds, highly similar to Serotransferrin precursor. AK295334 - Homo sapiens cDNA FLJ54029 complete cds, highly similar to Serotransferrin precursor. AK222755 - Homo sapiens mRNA for transferrin variant, clone: HEP00268. AK295419 - Homo sapiens cDNA FLJ54111 complete cds, highly similar to Serotransferrin precursor. AK303753 - Homo sapiens cDNA FLJ53691 complete cds, highly similar to Serotransferrin precursor. BX648533 - Homo sapiens mRNA; cDNA DKFZp686O0685 (from clone DKFZp686O0685). BC059367 - Homo sapiens transferrin, mRNA (cDNA clone MGC:71545 IMAGE:5264299), complete cds. GQ472199 - Homo sapiens epididymis secretory sperm binding protein Li 71p (HEL-S-71p) mRNA, complete cds. S95936 - transferrin [human, liver, mRNA, 2347 nt]. DQ923758 - Homo sapiens transferrin (TF) mRNA, complete cds. JD137928 - Sequence 118952 from Patent EP1572962. M12530 - Human transferrin mRNA, complete cds. JD024586 - Sequence 5610 from Patent EP1572962. JD029398 - Sequence 10422 from Patent EP1572962. AB590492 - Synthetic construct DNA, clone: pFN21AE2058, Homo sapiens TF gene for transferrin, without stop codon, in Flexi system. KJ897654 - Synthetic construct Homo sapiens clone ccsbBroadEn_07048 TF gene, encodes complete protein. AF118063 - Homo sapiens PRO1400 mRNA, complete cds. BC020671 - Homo sapiens transferrin, mRNA (cDNA clone IMAGE:4722434), partial cds. JD024897 - Sequence 5921 from Patent EP1572962. JD028223 - Sequence 9247 from Patent EP1572962. M12525 - Human transferrin mRNA, 3' end. AK126941 - Homo sapiens cDNA FLJ44994 fis, clone BRAWH3010560. BC022262 - Homo sapiens transferrin, mRNA (cDNA clone IMAGE:4734580), with apparent retained intron. BX537660 - Homo sapiens mRNA; cDNA DKFZp686L1398 (from clone DKFZp686L1398). U88581 - Human transferrin mRNA, C2 allele, partial cds. M26641 - Human transferrin. JD454187 - Sequence 435211 from Patent EP1572962. JD376900 - Sequence 357924 from Patent EP1572962. JD430451 - Sequence 411475 from Patent EP1572962. JD529661 - Sequence 510685 from Patent EP1572962. JD170172 - Sequence 151196 from Patent EP1572962. JD307037 - Sequence 288061 from Patent EP1572962. JD322915 - Sequence 303939 from Patent EP1572962. JD401574 - Sequence 382598 from Patent EP1572962. JD201511 - Sequence 182535 from Patent EP1572962. JD291428 - Sequence 272452 from Patent EP1572962. JD431121 - Sequence 412145 from Patent EP1572962. JD532486 - Sequence 513510 from Patent EP1572962. JD443761 - Sequence 424785 from Patent EP1572962. JD194377 - Sequence 175401 from Patent EP1572962. JD401776 - Sequence 382800 from Patent EP1572962. JD165429 - Sequence 146453 from Patent EP1572962. DQ594916 - Homo sapiens piRNA piR-61028, complete sequence. DQ581620 - Homo sapiens piRNA piR-49732, complete sequence. DQ578550 - Homo sapiens piRNA piR-46662, complete sequence. DQ591787 - Homo sapiens piRNA piR-58899, complete sequence. DQ591044 - Homo sapiens piRNA piR-58156, complete sequence. DQ571320 - Homo sapiens piRNA piR-31432, complete sequence. JD549343 - Sequence 530367 from Patent EP1572962. JD549344 - Sequence 530368 from Patent EP1572962. BC041815 - Homo sapiens cDNA clone IMAGE:5266959. JD153097 - Sequence 134121 from Patent EP1572962. JD153100 - Sequence 134124 from Patent EP1572962. JD198381 - Sequence 179405 from Patent EP1572962. JD272029 - Sequence 253053 from Patent EP1572962. JD153098 - Sequence 134122 from Patent EP1572962. JD153099 - Sequence 134123 from Patent EP1572962. JD198380 - Sequence 179404 from Patent EP1572962. JD272028 - Sequence 253052 from Patent EP1572962. JD479277 - Sequence 460301 from Patent EP1572962. JD113647 - Sequence 94671 from Patent EP1572962. JD291161 - Sequence 272185 from Patent EP1572962. JD358548 - Sequence 339572 from Patent EP1572962. JD527560 - Sequence 508584 from Patent EP1572962. JD527562 - Sequence 508586 from Patent EP1572962. JD160966 - Sequence 141990 from Patent EP1572962. JD160960 - Sequence 141984 from Patent EP1572962. JD546540 - Sequence 527564 from Patent EP1572962. JD546541 - Sequence 527565 from Patent EP1572962. JD081606 - Sequence 62630 from Patent EP1572962. JD433483 - Sequence 414507 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_eea1Pathway - The role of FYVE-finger proteins in vesicle transport
Reactome (by CSHL, EBI, and GO)
Protein P02787 (Reactome details) participates in the following event(s):
R-HSA-917888 apoTF binds 2Fe3+ to form holoTF R-HSA-917839 apo-Transferrin dissociates from the receptor complex R-HSA-482770 Release of platelet secretory granule components R-HSA-917814 apoTF:TFRC dimer translocates from endosome membrane to plasma membrane R-HSA-917987 TFRC dimer binds 2xholoTF R-HSA-5691150 TFR2 dimer binds 2xholoTF R-HSA-917835 Fe3+ dissociates from holoTF:TFRC dimer R-HSA-8952289 FAM20C phosphorylates FAM20C substrates R-HSA-8866277 AP-2 directly binds some endocytic cargo R-HSA-8867756 CLASP proteins and cargo are recruited to the nascent clathrin-coated pit R-HSA-8868071 Clathrin recruits PIK3C2A R-HSA-8868661 Dynamin-mediated GTP hydrolysis promotes vesicle scission R-HSA-8868648 SYNJ hydrolyze PI(4,5)P2 to PI(4)P R-HSA-8871194 RAB5 and GAPVD1 bind AP-2 R-HSA-8868658 HSPA8-mediated ATP hydrolysis promotes vesicle uncoating R-HSA-8868659 Clathrin recruits auxilins to the clathrin-coated vesicle R-HSA-8868660 Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle R-HSA-8867754 F- and N- BAR domain proteins bind the clathrin-coated pit R-HSA-8868230 SNX9 recruits components of the actin polymerizing machinery R-HSA-8868072 Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 R-HSA-8868236 BAR domain proteins recruit dynamin R-HSA-8868651 Endophilins recruit synaptojanins to the clathrin-coated pit R-HSA-917937 Iron uptake and transport R-HSA-917977 Transferrin endocytosis and recycling R-HSA-114608 Platelet degranulation R-HSA-382551 Transport of small molecules R-HSA-76005 Response to elevated platelet cytosolic Ca2+ R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275 Post-translational protein phosphorylation R-HSA-76002 Platelet activation, signaling and aggregation R-HSA-392499 Metabolism of proteins R-HSA-597592 Post-translational protein modification R-HSA-109582 Hemostasis R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828 Clathrin-mediated endocytosis R-HSA-199991 Membrane Trafficking R-HSA-5653656 Vesicle-mediated transport
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
