ID:TIM50_HUMAN DESCRIPTION: RecName: Full=Mitochondrial import inner membrane translocase subunit TIM50; Flags: Precursor; FUNCTION: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo. Isoform 2 may participate in the release of snRNPs and SMN from the Cajal body. SUBUNIT: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50. Interacts directly with TIMM23. Isoform 2 interacts with COIL and snRNPs. INTERACTION: P10398:ARAF; NbExp=3; IntAct=EBI-355175, EBI-365961; P04049:RAF1; NbExp=3; IntAct=EBI-355175, EBI-365996; SUBCELLULAR LOCATION: Mitochondrion inner membrane; Single-pass membrane protein. SUBCELLULAR LOCATION: Isoform 2: Nucleus speckle. Note=Nuclear and enriched in speckles with snRNPs. TISSUE SPECIFICITY: Widely expressed. Expressed at higher level in brain, kidney and liver (at protein level). DOMAIN: The FCP1 homology domain does not contain the canonical D- x-D-x-[TV] active site, suggesting that it probably does not display phosphatase activity in vivo. SIMILARITY: Belongs to the TIM50 family. SIMILARITY: Contains 1 FCP1 homology domain. SEQUENCE CAUTION: Sequence=AAG35534.1; Type=Miscellaneous discrepancy; Note=Chimera;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q3ZCQ8
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003723 RNA binding GO:0004721 phosphoprotein phosphatase activity GO:0004722 protein serine/threonine phosphatase activity GO:0004725 protein tyrosine phosphatase activity GO:0005134 interleukin-2 receptor binding GO:0005515 protein binding GO:0043021 ribonucleoprotein complex binding
Biological Process: GO:0001836 release of cytochrome c from mitochondria GO:0006470 protein dephosphorylation GO:0007006 mitochondrial membrane organization GO:0015031 protein transport GO:0030150 protein import into mitochondrial matrix GO:0035335 peptidyl-tyrosine dephosphorylation
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
