Human Gene TMEM37 (ENST00000306406.5_7) from GENCODE V47lift37

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Description: transmembrane protein 37 (from RefSeq NM_183240.3)
Gencode Transcript: ENST00000306406.5_7
Gencode Gene: ENSG00000171227.7_11
Transcript (Including UTRs)
Position: hg19 chr2:120,189,430-120,196,080 Size: 6,651 Total Exon Count: 2 Strand: +
Coding Region
Position: hg19 chr2:120,189,480-120,195,016 Size: 5,537 Coding Exon Count: 2

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr2:120,189,430-120,196,080)			mRNA (may differ from genome)		Protein (190 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: CCGL_HUMAN DESCRIPTION: RecName: Full=Voltage-dependent calcium channel gamma-like subunit; AltName: Full=Neuronal voltage-gated calcium channel gamma-like subunit; AltName: Full=Transmembrane protein 37; FUNCTION: Thought to stabilize the calcium channel in an inactivated (closed) state. Modulates calcium current when coexpressed with CACNA1G (By similarity). SUBUNIT: The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma (By similarity). SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential). SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: TMEM37 Diseases sorted by gene-association score: vulvitis (1), poland syndrome (1)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D013749 Tetrachlorodibenzodioxin D008767 Methylmercury Compounds D013739 Testosterone C025589 ochratoxin A C014024 2,4,5,2',4',5'-hexachlorobiphenyl C049584 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine C023035 3,4,5,3',4'-pentachlorobiphenyl C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid C009505 4,4'-diaminodiphenylmethane D015127 9,10-Dimethyl-1,2-benzanthracene D000082 Acetaminophen D016604 Aflatoxin B1 D000393 Air Pollutants D000643 Ammonium Chloride D001564 Benzo(a)pyrene D019256 Cadmium Chloride D002117 Calcitriol D002211 Capsaicin D002251 Carbon Tetrachloride D019327 Copper Sulfate D016572 Cyclosporine D004041 Dietary Fats D004051 Diethylhexyl Phthalate D006882 Hydroxyapatites C523799 MRK 003 D010126 Ozone D059808 Polyphenols D053260 Soot D014028 Tobacco Smoke Pollution D014303 Trinitrotoluene D024483 Vitamin K 3 C006780 bisphenol A C045651 epigallocatechin gallate C051890 irinotecan C016599 mono-(2-ethylhexyl)phthalate C031721 naphthalene C041786 palm oil C027373 potassium chromate(VI) C031655 tauroursodeoxycholic acid

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 36.24 RPKM in Kidney - Cortex Total median expression: 249.98 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-21.90	50	-0.438	Picture	PostScript	Text
3' UTR	-383.30	1064	-0.360	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

Pfam Domains:
PF15108 - Voltage-dependent calcium channel gamma-like subunit protein family

ModBase Predicted Comparative 3D Structure on Q8WXS4


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005244 voltage-gated ion channel activity GO:0005262 calcium channel activity Biological Process: GO:0006811 ion transport GO:0006816 calcium ion transport GO:0034765 regulation of ion transmembrane transport GO:0070588 calcium ion transmembrane transport Cellular Component: GO:0016020 membrane GO:0016021 integral component of membrane

Descriptions from all associated GenBank mRNAs


	BC046362 - Homo sapiens transmembrane protein 37, mRNA (cDNA clone MGC:50757 IMAGE:5221396), complete cds. AF361356 - Homo sapiens voltage-dependent calcium channel gamma subunit-like protein mRNA, complete cds. KJ903810 - Synthetic construct Homo sapiens clone ccsbBroadEn_13204 TMEM37 gene, encodes complete protein. AK026464 - Homo sapiens cDNA: FLJ22811 fis, clone KAIA2944. JD204322 - Sequence 185346 from Patent EP1572962. JD168367 - Sequence 149391 from Patent EP1572962. JD408993 - Sequence 390017 from Patent EP1572962. JD493877 - Sequence 474901 from Patent EP1572962. JD230598 - Sequence 211622 from Patent EP1572962. JD508863 - Sequence 489887 from Patent EP1572962. JD091749 - Sequence 72773 from Patent EP1572962. JD081352 - Sequence 62376 from Patent EP1572962. JD142964 - Sequence 123988 from Patent EP1572962. JD202300 - Sequence 183324 from Patent EP1572962. JD122655 - Sequence 103679 from Patent EP1572962. JD377135 - Sequence 358159 from Patent EP1572962. JD162439 - Sequence 143463 from Patent EP1572962. JD283879 - Sequence 264903 from Patent EP1572962. JD296300 - Sequence 277324 from Patent EP1572962. JD131848 - Sequence 112872 from Patent EP1572962. JD343545 - Sequence 324569 from Patent EP1572962. JD482941 - Sequence 463965 from Patent EP1572962. JD047490 - Sequence 28514 from Patent EP1572962. JD553933 - Sequence 534957 from Patent EP1572962. JD535914 - Sequence 516938 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: CCGL_HUMAN, ENST00000306406.1, ENST00000306406.2, ENST00000306406.3, ENST00000306406.4, NM_183240, PR , Q8WXS4, TMEM37 , uc317nvr.1, uc317nvr.2 UCSC ID: ENST00000306406.5_7 RefSeq Accession: NM_183240.3 Protein: Q8WXS4 (aka CCGL_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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