Human Gene TMSB4X (ENST00000451311.7_4) from GENCODE V47lift37

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Description: thymosin beta 4 X-linked (from RefSeq NM_021109.4)
Gencode Transcript: ENST00000451311.7_4
Gencode Gene: ENSG00000205542.11_7
Transcript (Including UTRs)
Position: hg19 chrX:12,993,229-12,995,342 Size: 2,114 Total Exon Count: 3 Strand: +
Coding Region
Position: hg19 chrX:12,994,381-12,994,930 Size: 550 Coding Exon Count: 2

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chrX:12,993,229-12,995,342)			mRNA (may differ from genome)		Protein (44 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
Malacards	MGI	OMIM	PubMed	Reactome	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: TYB4_HUMAN DESCRIPTION: RecName: Full=Thymosin beta-4; Short=T beta-4; AltName: Full=Fx; Contains: RecName: Full=Hematopoietic system regulatory peptide; AltName: Full=Seraspenide; FUNCTION: Plays an important role in the organization of the cytoskeleton (By similarity). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. FUNCTION: Seraspenide inhibits the entry of hematopoietic pluripotent stem cells into the S-phase (By similarity). INTERACTION: P40692:MLH1; NbExp=16; IntAct=EBI-712598, EBI-744248; SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. TISSUE SPECIFICITY: Expressed in several hemopoietic cell lines and lymphoid malignant cells. Decreased levels in myeloma cells. INDUCTION: By alpha interferons. Decreased levels in THP-1 cells after treatment with recombinant interferon-lambda. SIMILARITY: Belongs to the thymosin beta family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
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Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: TMSB4X Diseases sorted by gene-association score: thymoma (3), invasive malignant thymoma (2)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D003993 Dibutyl Phthalate D014212 Tretinoin C006253 pirinixic acid C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid C002202 4-oxoretinoic acid D000082 Acetaminophen D016604 Aflatoxin B1 D001149 Arsenates D001241 Aspirin D001280 Atrazine more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 3315.45 RPKM in Cells - EBV-transformed lymphocytes Total median expression: 31789.63 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-17.30	75	-0.231	Picture	PostScript	Text
3' UTR	-99.70	412	-0.242	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR001152 - Thymosin_b4
IPR016323 - Thymosin_b4_chordata

Pfam Domains:
PF01290 - Thymosin beta-4 family
PF02205 - WH2 motif

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1UY5 - Model

3TU5 - X-ray MuPIT

ModBase Predicted Comparative 3D Structure on P62328


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003723 RNA binding GO:0003779 actin binding GO:0003785 actin monomer binding GO:0005515 protein binding GO:0019899 enzyme binding Biological Process: GO:0002576 platelet degranulation GO:0007015 actin filament organization GO:0007253 cytoplasmic sequestering of NF-kappaB GO:0032088 negative regulation of NF-kappaB transcription factor activity GO:0033209 tumor necrosis factor-mediated signaling pathway GO:0042989 sequestering of actin monomers GO:0043536 positive regulation of blood vessel endothelial cell migration GO:0050727 regulation of inflammatory response GO:1901222 regulation of NIK/NF-kappaB signaling GO:1901223 negative regulation of NIK/NF-kappaB signaling GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding GO:1905273 positive regulation of proton-transporting ATP synthase activity, rotational mechanism GO:2000483 negative regulation of interleukin-8 secretion GO:2001028 positive regulation of endothelial cell chemotaxis GO:2001171 positive regulation of ATP biosynthetic process Cellular Component: GO:0005576 extracellular region GO:0005622 intracellular GO:0005634 nucleus GO:0005737 cytoplasm GO:0005829 cytosol GO:0005856 cytoskeleton GO:0031093 platelet alpha granule lumen

Descriptions from all associated GenBank mRNAs


	BC107789 - Homo sapiens cDNA clone IMAGE:6718122. M17733 - Human thymosin beta-4 mRNA, complete cds. AK311747 - Homo sapiens cDNA, FLJ92006, Homo sapiens thymosin, beta 4, X chromosome (TMSB4X), mRNA. BC070248 - Homo sapiens thymosin beta 4, X-linked, mRNA (cDNA clone IMAGE:3996900), partial cds. BC083509 - Homo sapiens thymosin beta 4, X-linked, mRNA (cDNA clone IMAGE:4718379), partial cds. BC022857 - Homo sapiens thymosin beta 4, X-linked, mRNA (cDNA clone IMAGE:4095465), partial cds. BC062436 - Homo sapiens thymosin beta 4, X-linked, mRNA (cDNA clone IMAGE:4251419), partial cds. BC070249 - Homo sapiens thymosin, beta 4, X-linked, mRNA (cDNA clone IMAGE:6727183). BC016732 - Homo sapiens thymosin beta 4, X-linked, mRNA (cDNA clone IMAGE:4096207), partial cds. AK055976 - Homo sapiens cDNA FLJ31414 fis, clone NT2NE2000260, weakly similar to THYMOSIN BETA-4. AK057827 - Homo sapiens cDNA FLJ25098 fis, clone CBR01237. BC092437 - Homo sapiens thymosin beta 4, X-linked, mRNA (cDNA clone IMAGE:30414016), partial cds. BC104666 - Homo sapiens thymosin beta 4, X-linked, mRNA (cDNA clone IMAGE:6648916), partial cds. E00899 - cDNA to mRNA produced by stimulating malignant myeloid cell (HL-60) by in vitro differentiation. E01650 - cDNA encoding the factor which induces differentiation of myeloma. BC061586 - Homo sapiens thymosin beta 4, X-linked, mRNA (cDNA clone IMAGE:6502613), partial cds. BC151215 - Homo sapiens thymosin beta 4, X-linked, mRNA (cDNA clone MGC:164871 IMAGE:40148015), complete cds. BC139925 - Homo sapiens thymosin beta 4, X-linked, mRNA (cDNA clone MGC:165110 IMAGE:40148985), complete cds. BC101790 - Homo sapiens thymosin beta 4, X-linked, mRNA (cDNA clone MGC:126839 IMAGE:8069296), complete cds. BC101792 - Homo sapiens thymosin beta 4, X-linked, mRNA (cDNA clone MGC:126841 IMAGE:8069298), complete cds. BC001631 - Homo sapiens thymosin beta 4, X-linked, mRNA (cDNA clone IMAGE:3536637), partial cds. BC064954 - Homo sapiens thymosin beta 4, X-linked, mRNA (cDNA clone IMAGE:6054203), partial cds. BC128103 - Homo sapiens thymosin beta 4, X-linked, mRNA (cDNA clone MGC:149183 IMAGE:40112043), complete cds. BC141975 - Homo sapiens thymosin beta 4, X-linked, mRNA (cDNA clone MGC:165320 IMAGE:40112044), complete cds. BC141976 - Homo sapiens thymosin beta 4, X-linked, mRNA (cDNA clone MGC:165321 IMAGE:40112045), complete cds. BC128102 - Homo sapiens thymosin beta 4, X-linked, mRNA (cDNA clone MGC:149182 IMAGE:40112039), complete cds. BC104464 - Homo sapiens thymosin beta 4, X-linked, mRNA (cDNA clone MGC:129940 IMAGE:40031330), complete cds. BC104465 - Homo sapiens thymosin beta 4, X-linked, mRNA (cDNA clone MGC:129941 IMAGE:40031337), complete cds. LF383189 - JP 2014500723-A/190692: Polycomb-Associated Non-Coding RNAs. BT007090 - Homo sapiens thymosin, beta 4, X chromosome mRNA, complete cds. X02493 - Human interferon-inducible mRNA (cDNA 6-26). DL492075 - Novel nucleic acids. M11948 - Human promyelocytic leukemia cell mRNA, clones pHH58 and pHH81. JD026184 - Sequence 7208 from Patent EP1572962. JD023797 - Sequence 4821 from Patent EP1572962. LF383188 - JP 2014500723-A/190691: Polycomb-Associated Non-Coding RNAs. JD031229 - Sequence 12253 from Patent EP1572962. JD044948 - Sequence 25972 from Patent EP1572962. JD352303 - Sequence 333327 from Patent EP1572962. JD228113 - Sequence 209137 from Patent EP1572962. JD342804 - Sequence 323828 from Patent EP1572962. LF383187 - JP 2014500723-A/190690: Polycomb-Associated Non-Coding RNAs. JD042804 - Sequence 23828 from Patent EP1572962. JD436032 - Sequence 417056 from Patent EP1572962. JD344371 - Sequence 325395 from Patent EP1572962. JD312428 - Sequence 293452 from Patent EP1572962. MA618766 - JP 2018138019-A/190692: Polycomb-Associated Non-Coding RNAs. MA618765 - JP 2018138019-A/190691: Polycomb-Associated Non-Coding RNAs. MA618764 - JP 2018138019-A/190690: Polycomb-Associated Non-Coding RNAs.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein P62328 (Reactome details) participates in the following event(s): R-HSA-481007 Exocytosis of platelet alpha granule contents R-HSA-114608 Platelet degranulation R-HSA-76005 Response to elevated platelet cytosolic Ca2+ R-HSA-76002 Platelet activation, signaling and aggregation R-HSA-109582 Hemostasis

Other Names for This Gene


	Alternate Gene Symbols: ENST00000451311.1, ENST00000451311.2, ENST00000451311.3, ENST00000451311.4, ENST00000451311.5, ENST00000451311.6, NM_021109, P01253, P01254, P62328, Q546P5, Q63576, Q9UE55, TB4X, THYB4, TMSB4, TYB4_HUMAN, uc320srr.1, uc320srr.2 UCSC ID: ENST00000451311.7_4 RefSeq Accession: NM_021109.4 Protein: P62328 (aka TYB4_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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