Human Gene TNC (ENST00000350763.9_8) from GENCODE V47lift37
Description: tenascin C (from RefSeq NM_002160.4)Gencode Transcript: ENST00000350763.9_8Gencode Gene: ENSG00000041982.17_17Transcript (Including UTRs) Position: hg19 chr9:117,781,854-117,880,436 Size: 98,583 Total Exon Count: 28 Strand: -Coding Region Position: hg19 chr9:117,783,436-117,853,297 Size: 69,862 Coding Exon Count: 27
Data last updated at UCSC: 2024-08-22 23:36:26
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: TENA_HUMAN DESCRIPTION: RecName: Full=Tenascin; Short=TN; AltName: Full=Cytotactin; AltName: Full=GMEM; AltName: Full=GP 150-225; AltName: Full=Glioma-associated-extracellular matrix antigen; AltName: Full=Hexabrachion; AltName: Full=JI; AltName: Full=Myotendinous antigen; AltName: Full=Neuronectin; AltName: Full=Tenascin-C; Short=TN-C; Flags: Precursor;FUNCTION: Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.SUBUNIT: Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4.SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.INDUCTION: By TGFB1.SIMILARITY: Belongs to the tenascin family.SIMILARITY: Contains 15 EGF-like domains.SIMILARITY: Contains 1 fibrinogen C-terminal domain.SIMILARITY: Contains 15 fibronectin type-III domains.WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/TNCID42597ch9q33.html";
Primer design for this transcript
MalaCards Disease Associations
MalaCards Gene Search: TNC
Diseases sorted by gene-association score: deafness, autosomal dominant 56 * (1240), autosomal dominant non-syndromic sensorineural deafness type dfna * (101), bullous keratopathy (31), interstitial pneumonitis, desquamative, familial (16), tetanus neonatorum (11), tibial neuropathy (11), tarsal tunnel syndrome (11), acute myocarditis (11), juvenile pilocytic astrocytoma (10), sialadenitis (9), cryptogenic organizing pneumonia (8), cardiac sarcoidosis (8), keloids (7), actinic keratosis (7), deep keratitis (7), light chain deposition disease (6), interstitial keratitis (6), keratopathy (6), glioma (4)* = Manually curated disease association
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR000742 - EG-like_domIPR013032 - EGF-like_CSIPR013111 - EGF_extracellIPR002181 - Fibrinogen_a/b/g_CIPR014716 - Fibrinogen_a/b/g_C_1IPR014715 - Fibrinogen_a/b/g_C_2IPR003961 - Fibronectin_type3IPR013783 - Ig-like_foldPfam Domains: PF00041 - Fibronectin type III domainPF00147 - Fibrinogen beta and gamma chains, C-terminal globular domainPF07974 - EGF-like domainPF18720 - Tenascin EGF domainSCOP Domains: 49363 - Purple acid phosphatase, N-terminal domain49265 - Fibronectin type III55961 - Bet v1-like56496 - Fibrinogen C-terminal domain-like57196 - EGF/LamininProtein Data Bank (PDB) 3-D Structure ModBase Predicted Comparative 3D Structure on P24821 The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
M55618 - Homo sapiens hexabrachion (HXB) mRNA, complete cds.JA482199 - Sequence 182 from Patent WO2011072091.JE980491 - Sequence 182 from Patent EP2862929.AB210038 - Homo sapiens mRNA for TNC variant protein, clone: pf00008.AK304015 - Homo sapiens cDNA FLJ60213 complete cds, highly similar to Tenascin precursor.LF213716 - JP 2014500723-A/21219: Polycomb-Associated Non-Coding RNAs.LF206489 - JP 2014500723-A/13992: Polycomb-Associated Non-Coding RNAs.X56160 - Human mRNA for tenascin.X78565 - H.sapiens mRNA for tenascin-C, 7560bp.BC151843 - Homo sapiens tenascin C, mRNA (cDNA clone MGC:167029 IMAGE:8860362), complete cds.GU473235 - Homo sapiens tenascin-C isoform 14/AD1/16 mRNA, complete cds, alternatively spliced.KJ904485 - Synthetic construct Homo sapiens clone ccsbBroadEn_13879 TNC-like gene, encodes complete protein.AB384681 - Synthetic construct DNA, clone: pF1KB0063, Homo sapiens TNC gene for tenascin precursor, complete cds, without stop codon, in Flexi system.M24630 - Human hexabrachion mRNA, partial cds.LF206490 - JP 2014500723-A/13993: Polycomb-Associated Non-Coding RNAs.MA449293 - JP 2018138019-A/21219: Polycomb-Associated Non-Coding RNAs.MA442066 - JP 2018138019-A/13992: Polycomb-Associated Non-Coding RNAs.MA442067 - JP 2018138019-A/13993: Polycomb-Associated Non-Coding RNAs.JD351042 - Sequence 332066 from Patent EP1572962.JD182547 - Sequence 163571 from Patent EP1572962.JD331802 - Sequence 312826 from Patent EP1572962.JD308767 - Sequence 289791 from Patent EP1572962.JD096329 - Sequence 77353 from Patent EP1572962.JD138170 - Sequence 119194 from Patent EP1572962.JD175612 - Sequence 156636 from Patent EP1572962.JD331803 - Sequence 312827 from Patent EP1572962.JD452152 - Sequence 433176 from Patent EP1572962.LF355048 - JP 2014500723-A/162551: Polycomb-Associated Non-Coding RNAs.JD176028 - Sequence 157052 from Patent EP1572962.JD096164 - Sequence 77188 from Patent EP1572962.JD448921 - Sequence 429945 from Patent EP1572962.JD288260 - Sequence 269284 from Patent EP1572962.LF355049 - JP 2014500723-A/162552: Polycomb-Associated Non-Coding RNAs.LF355050 - JP 2014500723-A/162553: Polycomb-Associated Non-Coding RNAs.JD207334 - Sequence 188358 from Patent EP1572962.LF355051 - JP 2014500723-A/162554: Polycomb-Associated Non-Coding RNAs.JD262866 - Sequence 243890 from Patent EP1572962.JD153449 - Sequence 134473 from Patent EP1572962.LF355052 - JP 2014500723-A/162555: Polycomb-Associated Non-Coding RNAs.JD333923 - Sequence 314947 from Patent EP1572962.JD393417 - Sequence 374441 from Patent EP1572962.JD038668 - Sequence 19692 from Patent EP1572962.JD338480 - Sequence 319504 from Patent EP1572962.JD454498 - Sequence 435522 from Patent EP1572962.JD359246 - Sequence 340270 from Patent EP1572962.LF355053 - JP 2014500723-A/162556: Polycomb-Associated Non-Coding RNAs.LF355054 - JP 2014500723-A/162557: Polycomb-Associated Non-Coding RNAs.LF355055 - JP 2014500723-A/162558: Polycomb-Associated Non-Coding RNAs.LF355056 - JP 2014500723-A/162559: Polycomb-Associated Non-Coding RNAs.LF355057 - JP 2014500723-A/162560: Polycomb-Associated Non-Coding RNAs.LF355058 - JP 2014500723-A/162561: Polycomb-Associated Non-Coding RNAs.LF355059 - JP 2014500723-A/162562: Polycomb-Associated Non-Coding RNAs.LF355060 - JP 2014500723-A/162563: Polycomb-Associated Non-Coding RNAs.LF355061 - JP 2014500723-A/162564: Polycomb-Associated Non-Coding RNAs.LF355062 - JP 2014500723-A/162565: Polycomb-Associated Non-Coding RNAs.LF355063 - JP 2014500723-A/162566: Polycomb-Associated Non-Coding RNAs.LF355064 - JP 2014500723-A/162567: Polycomb-Associated Non-Coding RNAs.LF355065 - JP 2014500723-A/162568: Polycomb-Associated Non-Coding RNAs.LF355066 - JP 2014500723-A/162569: Polycomb-Associated Non-Coding RNAs.LF355067 - JP 2014500723-A/162570: Polycomb-Associated Non-Coding RNAs.LF355068 - JP 2014500723-A/162571: Polycomb-Associated Non-Coding RNAs.AK024586 - Homo sapiens cDNA: FLJ20933 fis, clone ADSE01388.LF355070 - JP 2014500723-A/162573: Polycomb-Associated Non-Coding RNAs.LF355071 - JP 2014500723-A/162574: Polycomb-Associated Non-Coding RNAs.BX641111 - Homo sapiens mRNA; cDNA DKFZp686B15117 (from clone DKFZp686B15117).LF355075 - JP 2014500723-A/162578: Polycomb-Associated Non-Coding RNAs.LF355076 - JP 2014500723-A/162579: Polycomb-Associated Non-Coding RNAs.LF355077 - JP 2014500723-A/162580: Polycomb-Associated Non-Coding RNAs.LF355078 - JP 2014500723-A/162581: Polycomb-Associated Non-Coding RNAs.LF355081 - JP 2014500723-A/162584: Polycomb-Associated Non-Coding RNAs.LF355082 - JP 2014500723-A/162585: Polycomb-Associated Non-Coding RNAs.LF355083 - JP 2014500723-A/162586: Polycomb-Associated Non-Coding RNAs.LF355078 - JP 2014500723-A/162581: Polycomb-Associated Non-Coding RNAs.MA590625 - JP 2018138019-A/162551: Polycomb-Associated Non-Coding RNAs.MA590626 - JP 2018138019-A/162552: Polycomb-Associated Non-Coding RNAs.MA590627 - JP 2018138019-A/162553: Polycomb-Associated Non-Coding RNAs.MA590628 - JP 2018138019-A/162554: Polycomb-Associated Non-Coding RNAs.MA590629 - JP 2018138019-A/162555: Polycomb-Associated Non-Coding RNAs.MA590630 - JP 2018138019-A/162556: Polycomb-Associated Non-Coding RNAs.MA590631 - JP 2018138019-A/162557: Polycomb-Associated Non-Coding RNAs.MA590632 - JP 2018138019-A/162558: Polycomb-Associated Non-Coding RNAs.MA590633 - JP 2018138019-A/162559: Polycomb-Associated Non-Coding RNAs.MA590634 - JP 2018138019-A/162560: Polycomb-Associated Non-Coding RNAs.MA590635 - JP 2018138019-A/162561: Polycomb-Associated Non-Coding RNAs.MA590636 - JP 2018138019-A/162562: Polycomb-Associated Non-Coding RNAs.MA590637 - JP 2018138019-A/162563: Polycomb-Associated Non-Coding RNAs.MA590638 - JP 2018138019-A/162564: Polycomb-Associated Non-Coding RNAs.MA590639 - JP 2018138019-A/162565: Polycomb-Associated Non-Coding RNAs.MA590640 - JP 2018138019-A/162566: Polycomb-Associated Non-Coding RNAs.MA590641 - JP 2018138019-A/162567: Polycomb-Associated Non-Coding RNAs.MA590642 - JP 2018138019-A/162568: Polycomb-Associated Non-Coding RNAs.MA590643 - JP 2018138019-A/162569: Polycomb-Associated Non-Coding RNAs.MA590644 - JP 2018138019-A/162570: Polycomb-Associated Non-Coding RNAs.MA590645 - JP 2018138019-A/162571: Polycomb-Associated Non-Coding RNAs.MA590647 - JP 2018138019-A/162573: Polycomb-Associated Non-Coding RNAs.MA590648 - JP 2018138019-A/162574: Polycomb-Associated Non-Coding RNAs.MA590652 - JP 2018138019-A/162578: Polycomb-Associated Non-Coding RNAs.MA590653 - JP 2018138019-A/162579: Polycomb-Associated Non-Coding RNAs.MA590654 - JP 2018138019-A/162580: Polycomb-Associated Non-Coding RNAs.MA590655 - JP 2018138019-A/162581: Polycomb-Associated Non-Coding RNAs.MA590658 - JP 2018138019-A/162584: Polycomb-Associated Non-Coding RNAs.MA590659 - JP 2018138019-A/162585: Polycomb-Associated Non-Coding RNAs.MA590660 - JP 2018138019-A/162586: Polycomb-Associated Non-Coding RNAs.MA590655 - JP 2018138019-A/162581: Polycomb-Associated Non-Coding RNAs.LF355087 - JP 2014500723-A/162590: Polycomb-Associated Non-Coding RNAs.LF355088 - JP 2014500723-A/162591: Polycomb-Associated Non-Coding RNAs.LF355089 - JP 2014500723-A/162592: Polycomb-Associated Non-Coding RNAs.LF355090 - JP 2014500723-A/162593: Polycomb-Associated Non-Coding RNAs.LF355091 - JP 2014500723-A/162594: Polycomb-Associated Non-Coding RNAs.LF355092 - JP 2014500723-A/162595: Polycomb-Associated Non-Coding RNAs.LF355093 - JP 2014500723-A/162596: Polycomb-Associated Non-Coding RNAs.LF355094 - JP 2014500723-A/162597: Polycomb-Associated Non-Coding RNAs.LF355095 - JP 2014500723-A/162598: Polycomb-Associated Non-Coding RNAs.LF355097 - JP 2014500723-A/162600: Polycomb-Associated Non-Coding RNAs.LF355098 - JP 2014500723-A/162601: Polycomb-Associated Non-Coding RNAs.LF355099 - JP 2014500723-A/162602: Polycomb-Associated Non-Coding RNAs.LF355100 - JP 2014500723-A/162603: Polycomb-Associated Non-Coding RNAs.LF355101 - JP 2014500723-A/162604: Polycomb-Associated Non-Coding RNAs.LF355102 - JP 2014500723-A/162605: Polycomb-Associated Non-Coding RNAs.LF355103 - JP 2014500723-A/162606: Polycomb-Associated Non-Coding RNAs.LF355104 - JP 2014500723-A/162607: Polycomb-Associated Non-Coding RNAs.LF355105 - JP 2014500723-A/162608: Polycomb-Associated Non-Coding RNAs.LF355106 - JP 2014500723-A/162609: Polycomb-Associated Non-Coding RNAs.LF355107 - JP 2014500723-A/162610: Polycomb-Associated Non-Coding RNAs.LF355108 - JP 2014500723-A/162611: Polycomb-Associated Non-Coding RNAs.LF355109 - JP 2014500723-A/162612: Polycomb-Associated Non-Coding RNAs.LF355110 - JP 2014500723-A/162613: Polycomb-Associated Non-Coding RNAs.LF355111 - JP 2014500723-A/162614: Polycomb-Associated Non-Coding RNAs.LF355112 - JP 2014500723-A/162615: Polycomb-Associated Non-Coding RNAs.X80280 - H.sapiens tenascin mRNA.LF355113 - JP 2014500723-A/162616: Polycomb-Associated Non-Coding RNAs.LF355114 - JP 2014500723-A/162617: Polycomb-Associated Non-Coding RNAs.JD360507 - Sequence 341531 from Patent EP1572962.JD130575 - Sequence 111599 from Patent EP1572962.LF355115 - JP 2014500723-A/162618: Polycomb-Associated Non-Coding RNAs.LF355123 - JP 2014500723-A/162626: Polycomb-Associated Non-Coding RNAs.JD058367 - Sequence 39391 from Patent EP1572962.JD096767 - Sequence 77791 from Patent EP1572962.JD140011 - Sequence 121035 from Patent EP1572962.MA590664 - JP 2018138019-A/162590: Polycomb-Associated Non-Coding RNAs.MA590665 - JP 2018138019-A/162591: Polycomb-Associated Non-Coding RNAs.MA590666 - JP 2018138019-A/162592: Polycomb-Associated Non-Coding RNAs.MA590667 - JP 2018138019-A/162593: Polycomb-Associated Non-Coding RNAs.MA590668 - JP 2018138019-A/162594: Polycomb-Associated Non-Coding RNAs.MA590669 - JP 2018138019-A/162595: Polycomb-Associated Non-Coding RNAs.MA590670 - JP 2018138019-A/162596: Polycomb-Associated Non-Coding RNAs.MA590671 - JP 2018138019-A/162597: Polycomb-Associated Non-Coding RNAs.MA590672 - JP 2018138019-A/162598: Polycomb-Associated Non-Coding RNAs.MA590674 - JP 2018138019-A/162600: Polycomb-Associated Non-Coding RNAs.MA590675 - JP 2018138019-A/162601: Polycomb-Associated Non-Coding RNAs.MA590676 - JP 2018138019-A/162602: Polycomb-Associated Non-Coding RNAs.MA590677 - JP 2018138019-A/162603: Polycomb-Associated Non-Coding RNAs.MA590678 - JP 2018138019-A/162604: Polycomb-Associated Non-Coding RNAs.MA590679 - JP 2018138019-A/162605: Polycomb-Associated Non-Coding RNAs.MA590680 - JP 2018138019-A/162606: Polycomb-Associated Non-Coding RNAs.MA590681 - JP 2018138019-A/162607: Polycomb-Associated Non-Coding RNAs.MA590682 - JP 2018138019-A/162608: Polycomb-Associated Non-Coding RNAs.MA590683 - JP 2018138019-A/162609: Polycomb-Associated Non-Coding RNAs.MA590684 - JP 2018138019-A/162610: Polycomb-Associated Non-Coding RNAs.MA590685 - JP 2018138019-A/162611: Polycomb-Associated Non-Coding RNAs.MA590686 - JP 2018138019-A/162612: Polycomb-Associated Non-Coding RNAs.MA590687 - JP 2018138019-A/162613: Polycomb-Associated Non-Coding RNAs.MA590688 - JP 2018138019-A/162614: Polycomb-Associated Non-Coding RNAs.MA590689 - JP 2018138019-A/162615: Polycomb-Associated Non-Coding RNAs.MA590690 - JP 2018138019-A/162616: Polycomb-Associated Non-Coding RNAs.MA590691 - JP 2018138019-A/162617: Polycomb-Associated Non-Coding RNAs.MA590692 - JP 2018138019-A/162618: Polycomb-Associated Non-Coding RNAs.MA590700 - JP 2018138019-A/162626: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO) Reactome details) participates in the following event(s):R-HSA-265426 Interaction of integrin alphaVbeta3 with TenascinR-HSA-2681694 TNC binds Syndecan-3R-HSA-216064 Interaction of integrin alpha8beta1 with Tenascin-CR-HSA-216068 Interaction of integrin alpha9beta1 with Tenascin-CR-HSA-2681667 TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1R-HSA-2424246 Tenascins C, R, (X, N) bind lecticansR-HSA-2681681 Tenascins C, R, (X, N) bind fibronectin matrixR-HSA-8952289 FAM20C phosphorylates FAM20C substratesR-HSA-216083 Integrin cell surface interactionsR-HSA-3000170 Syndecan interactionsR-HSA-3000178 ECM proteoglycansR-HSA-1474244 Extracellular matrix organizationR-HSA-3000171 Non-integrin membrane-ECM interactionsR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)R-HSA-8957275 Post-translational protein phosphorylationR-HSA-392499 Metabolism of proteinsR-HSA-597592 Post-translational protein modification
Other Names for This Gene
Alternate Gene Symbols: C9IYT7, C9J575, C9J6D9, C9J848, ENST00000350763.1, ENST00000350763.2, ENST00000350763.3, ENST00000350763.4, ENST00000350763.5, ENST00000350763.6, ENST00000350763.7, ENST00000350763.8, HXB, NM_002160, P24821, Q14583, Q15567, Q5T7S3, TENA_HUMAN, uc317yae.1, uc317yae.2UCSC ID: ENST00000350763.9_8RefSeq Accession: NM_002160.4 Protein: P24821
(aka TENA_HUMAN)
Gene Model Information
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for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
