ID:TONSL_HUMAN DESCRIPTION: RecName: Full=Tonsoku-like protein; AltName: Full=Inhibitor of kappa B-related protein; Short=I-kappa-B-related protein; Short=IkappaBR; AltName: Full=NF-kappa-B inhibitor-like protein 2; AltName: Full=Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2; FUNCTION: Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork- associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold. SUBUNIT: Component of the MMS22L-TONSL complex, a complex at least composed of MMS22L and TONSL/NFKBIL2. Interacts with the MCM complex, the FACT complex and the RPA complex. Binds histones. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Mainly nuclear. Localizes to DNA damage sites, accumulates at stressed replication forks. TISSUE SPECIFICITY: Expressed in heart, skeletal muscle and tracheal epithelial cells. DOMAIN: The ANK repeats mediate the interaction with the MCM complex and histones, while the LRR repeats mediate the interaction with MMS22L. SIMILARITY: Belongs to the Tonsoku family. SIMILARITY: Contains 3 ANK repeats. SIMILARITY: Contains 7 LRR (leucine-rich) repeats. SIMILARITY: Contains 8 TPR repeats. CAUTION: Was reported to share sequence similarities with IKBKB and therefore named 'NF-kappa-B inhibitor-like protein 2' (PubMed:7738005). However, the sequence similarity is remote and effects as regulator of NF-kappa-B are probably indirect and require additional evidence (PubMed:9242696). SEQUENCE CAUTION: Sequence=AAA85819.1; Type=Frameshift; Positions=Several; Sequence=AAH08782.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAB63467.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96HA7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
