Human Gene TPD52L2 (ENST00000346249.9_5) from GENCODE V47lift37

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Description: TPD52 like 2, transcript variant 11 (from RefSeq NR_045090.2)
Gencode Transcript: ENST00000346249.9_5
Gencode Gene: ENSG00000101150.18_13
Transcript (Including UTRs)
Position: hg19 chr20:62,496,623-62,522,891 Size: 26,269 Total Exon Count: 7 Strand: +
Coding Region
Position: hg19 chr20:62,496,719-62,521,298 Size: 24,580 Coding Exon Count: 7

Page Index	Sequence and Links	Primers	MalaCards	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr20:62,496,623-62,522,891)			mRNA (may differ from genome)		Protein (206 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: TPD52L2 Diseases sorted by gene-association score: breast cancer (3)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl C016403 2,4-dinitrotoluene C023514 2,6-dinitrotoluene C009505 4,4'-diaminodiphenylmethane C105260 4-tert-octylphenol D000082 Acetaminophen D001151 Arsenic D001241 Aspirin D001554 Benzene D001564 Benzo(a)pyrene more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 77.30 RPKM in Cells - Cultured fibroblasts Total median expression: 2672.40 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-34.70	96	-0.361	Picture	PostScript	Text
3' UTR	-558.50	1593	-0.351	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR007327 - TPD52

Pfam Domains:
PF04201 - Tumour protein D52 family

ModBase Predicted Comparative 3D Structure on Q6FGS1


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details		Gene Details
Gene Sorter	Gene Sorter		Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003824 catalytic activity GO:0005515 protein binding

Descriptions from all associated GenBank mRNAs


	AK298366 - Homo sapiens cDNA FLJ53635 complete cds, highly similar to Homo sapiens tumor protein D52-like 2 (TPD52L2), transcript variant 6, mRNA. AK055068 - Homo sapiens cDNA FLJ30506 fis, clone BRAWH2000522, highly similar to Homo sapiens tumor protein D52-like 2 (TPD52L2), transcript variant 4, mRNA. AK297064 - Homo sapiens cDNA FLJ54053 complete cds, highly similar to Homo sapiens tumor protein D52-like 2 (TPD52L2), transcript variant 6, mRNA. AF004430 - Homo sapiens hD54+ins2 isoform (hD54) mRNA, complete cds. AK223031 - Homo sapiens mRNA for tumor protein D52-like 2 isoform e variant, clone: JTH06723. AK293349 - Homo sapiens cDNA FLJ52530 complete cds, highly similar to Tumor protein D54. CR749208 - Homo sapiens mRNA; cDNA DKFZp686A1765 (from clone DKFZp686A1765). BC006804 - Homo sapiens tumor protein D52-like 2, mRNA (cDNA clone MGC:5064 IMAGE:3446037), complete cds. AB062396 - Homo sapiens OK/SW-cl.69 mRNA for tumor protein D52-like 2, complete cds. AF004429 - Homo sapiens D54 isoform (hD54) mRNA, partial cds. AK128744 - Homo sapiens cDNA FLJ44665 fis, clone BRACE3004371. AK125709 - Homo sapiens cDNA FLJ43721 fis, clone TESOP2006893. JD103841 - Sequence 84865 from Patent EP1572962. JD097722 - Sequence 78746 from Patent EP1572962. JD131683 - Sequence 112707 from Patent EP1572962. AK314501 - Homo sapiens cDNA, FLJ95317, highly similar to Homo sapiens tumor protein D52-like 2 (TPD52L2), mRNA. JD125416 - Sequence 106440 from Patent EP1572962. AY323819 - Homo sapiens HCCR-binding protein 2 mRNA, complete cds. DQ894300 - Synthetic construct Homo sapiens clone IMAGE:100008760; FLH169490.01L; RZPDo839C1295D tumor protein D52-like 2 (TPD52L2) gene, encodes complete protein. KJ892305 - Synthetic construct Homo sapiens clone ccsbBroadEn_01699 TPD52L2 gene, encodes complete protein. CU675461 - Synthetic construct Homo sapiens gateway clone IMAGE:100020634 5' read TPD52L2 mRNA. DQ891121 - Synthetic construct clone IMAGE:100003751; FLH169494.01X; RZPDo839C1296D tumor protein D52-like 2 (TPD52L2) gene, encodes complete protein. BT019631 - Homo sapiens tumor protein D52-like 2 mRNA, complete cds. CR542036 - Homo sapiens full open reading frame cDNA clone RZPDo834H1235D for gene TPD52L2, tumor protein D52-like 2; complete cds, incl. stopcodon. DQ591149 - Homo sapiens piRNA piR-58261, complete sequence. JD069348 - Sequence 50372 from Patent EP1572962. JD142317 - Sequence 123341 from Patent EP1572962. JD210921 - Sequence 191945 from Patent EP1572962. JD564982 - Sequence 546006 from Patent EP1572962. JD318317 - Sequence 299341 from Patent EP1572962. JD242228 - Sequence 223252 from Patent EP1572962. JD532068 - Sequence 513092 from Patent EP1572962. JD420687 - Sequence 401711 from Patent EP1572962. JD326780 - Sequence 307804 from Patent EP1572962. JD150487 - Sequence 131511 from Patent EP1572962. JD360278 - Sequence 341302 from Patent EP1572962. JD381953 - Sequence 362977 from Patent EP1572962. JD085918 - Sequence 66942 from Patent EP1572962. JD301819 - Sequence 282843 from Patent EP1572962. JD039164 - Sequence 20188 from Patent EP1572962. JD174106 - Sequence 155130 from Patent EP1572962. JD434477 - Sequence 415501 from Patent EP1572962. JD307378 - Sequence 288402 from Patent EP1572962. JD121423 - Sequence 102447 from Patent EP1572962. JD115141 - Sequence 96165 from Patent EP1572962. JD275152 - Sequence 256176 from Patent EP1572962. JD408212 - Sequence 389236 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: ENST00000346249.1, ENST00000346249.2, ENST00000346249.3, ENST00000346249.4, ENST00000346249.5, ENST00000346249.6, ENST00000346249.7, ENST00000346249.8, hCG_22755 , NR_045090, Q6FGS1, Q6FGS1_HUMAN, TPD52L2 , uc317xip.1, uc317xip.2 UCSC ID: ENST00000346249.9_5 RefSeq Accession: NM_003288.4 Protein: Q6FGS1

Gene Model Information


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Methods, Credits, and Use Restrictions


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