Human Gene TRAM2 (ENST00000182527.4_7) from GENCODE V47lift37
Description: translocation associated membrane protein 2 (from RefSeq NM_012288.4)Gencode Transcript: ENST00000182527.4_7Gencode Gene: ENSG00000065308.5_9Transcript (Including UTRs) Position: hg19 chr6:52,362,206-52,441,858 Size: 79,653 Total Exon Count: 11 Strand: -Coding Region Position: hg19 chr6:52,367,995-52,441,713 Size: 73,719 Coding Exon Count: 11
Data last updated at UCSC: 2024-08-22 23:36:26
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: TRAM2_HUMAN DESCRIPTION: RecName: Full=Translocating chain-associated membrane protein 2;FUNCTION: Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding.SUBUNIT: Interacts with SERCA2B and COL1A1.SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).SIMILARITY: Belongs to the TRAM family.SIMILARITY: Contains 1 TLC (TRAM/LAG1/CLN8) domain.SEQUENCE CAUTION: Sequence=BAA06540.2; Type=Erroneous initiation;
Primer design for this transcript
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
D013749
Tetrachlorodibenzodioxin
C006780
bisphenol A
C014024
2,4,5,2',4',5'-hexachlorobiphenyl
C012796
2-butenal
C023035
3,4,5,3',4'-pentachlorobiphenyl
D015123
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
D000082
Acetaminophen
D001104
Arbutin
D002117
Calcitriol
D002794
Choline
more ... click here to view the complete list
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR006634 - TLC-domIPR013599 - TRAM1IPR016447 - Translocation_assoc_membranePfam Domains: PF03798 - TLC domainPF08390 - TRAM1-like proteinSCOP Domains: 53955 - Lysozyme-likeModBase Predicted Comparative 3D Structure on Q15035 The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
D31762 - Homo sapiens KIAA0057 mRNA.AK291751 - Homo sapiens cDNA FLJ75727 complete cds, highly similar to Homo sapiens translocation associated membrane protein 2 (TRAM2), mRNA.BC028121 - Homo sapiens translocation associated membrane protein 2, mRNA (cDNA clone MGC:39954 IMAGE:5169808), complete cds.KJ892835 - Synthetic construct Homo sapiens clone ccsbBroadEn_02229 TRAM2 gene, encodes complete protein.AB383729 - Synthetic construct DNA, clone: pF1KSDA0057, Homo sapiens TRAM2 gene for translocation-associated membrane protein 2, complete cds, without stop codon, in Flexi system.DQ891068 - Synthetic construct clone IMAGE:100003698; FLH169038.01X; RZPDo839F1094D translocation associated membrane protein 2 (TRAM2) gene, encodes complete protein.DQ894250 - Synthetic construct Homo sapiens clone IMAGE:100008710; FLH169034.01L; RZPDo839F1093D translocation associated membrane protein 2 (TRAM2) gene, encodes complete protein.KU178488 - Homo sapiens translocation associated membrane protein 2 isoform 1 (TRAM2) mRNA, partial cds.KU178489 - Homo sapiens translocation associated membrane protein 2 isoform 2 (TRAM2) mRNA, complete cds, alternatively spliced.AB621814 - Homo sapiens TRAM2 mRNA for translocating chain-associated membrane protein 2, partial cds, clone: HP07574-RBdS083L19.LF205152 - JP 2014500723-A/12655: Polycomb-Associated Non-Coding RNAs.BC016804 - Homo sapiens translocation associated membrane protein 2, mRNA (cDNA clone IMAGE:4075403), with apparent retained intron.LF317126 - JP 2014500723-A/124629: Polycomb-Associated Non-Coding RNAs.JD368354 - Sequence 349378 from Patent EP1572962.JD073358 - Sequence 54382 from Patent EP1572962.JD094593 - Sequence 75617 from Patent EP1572962.JD282514 - Sequence 263538 from Patent EP1572962.JD448946 - Sequence 429970 from Patent EP1572962.JD287446 - Sequence 268470 from Patent EP1572962.JD377392 - Sequence 358416 from Patent EP1572962.JD457792 - Sequence 438816 from Patent EP1572962.DQ599325 - Homo sapiens piRNA piR-37391, complete sequence.JD120043 - Sequence 101067 from Patent EP1572962.LF205153 - JP 2014500723-A/12656: Polycomb-Associated Non-Coding RNAs.JD545336 - Sequence 526360 from Patent EP1572962.JD433484 - Sequence 414508 from Patent EP1572962.JD313681 - Sequence 294705 from Patent EP1572962.LF317127 - JP 2014500723-A/124630: Polycomb-Associated Non-Coding RNAs.JD252667 - Sequence 233691 from Patent EP1572962.LF317128 - JP 2014500723-A/124631: Polycomb-Associated Non-Coding RNAs.JD075606 - Sequence 56630 from Patent EP1572962.JD157171 - Sequence 138195 from Patent EP1572962.JD389957 - Sequence 370981 from Patent EP1572962.JD151619 - Sequence 132643 from Patent EP1572962.JD474355 - Sequence 455379 from Patent EP1572962.JD296455 - Sequence 277479 from Patent EP1572962.JD253137 - Sequence 234161 from Patent EP1572962.JD039050 - Sequence 20074 from Patent EP1572962.JD184858 - Sequence 165882 from Patent EP1572962.JD442491 - Sequence 423515 from Patent EP1572962.JD467889 - Sequence 448913 from Patent EP1572962.JD272189 - Sequence 253213 from Patent EP1572962.JD038757 - Sequence 19781 from Patent EP1572962.DQ599440 - Homo sapiens piRNA piR-37506, complete sequence.JD082605 - Sequence 63629 from Patent EP1572962.JD279872 - Sequence 260896 from Patent EP1572962.JD195363 - Sequence 176387 from Patent EP1572962.JD306205 - Sequence 287229 from Patent EP1572962.JD183533 - Sequence 164557 from Patent EP1572962.JD268962 - Sequence 249986 from Patent EP1572962.JD236611 - Sequence 217635 from Patent EP1572962.JD361937 - Sequence 342961 from Patent EP1572962.JD482228 - Sequence 463252 from Patent EP1572962.JD089668 - Sequence 70692 from Patent EP1572962.JD125046 - Sequence 106070 from Patent EP1572962.JD391923 - Sequence 372947 from Patent EP1572962.JD380015 - Sequence 361039 from Patent EP1572962.JD278639 - Sequence 259663 from Patent EP1572962.JD382915 - Sequence 363939 from Patent EP1572962.LF317129 - JP 2014500723-A/124632: Polycomb-Associated Non-Coding RNAs.JD043639 - Sequence 24663 from Patent EP1572962.JD170431 - Sequence 151455 from Patent EP1572962.JD566215 - Sequence 547239 from Patent EP1572962.JD378906 - Sequence 359930 from Patent EP1572962.JD269149 - Sequence 250173 from Patent EP1572962.JD073178 - Sequence 54202 from Patent EP1572962.JD320348 - Sequence 301372 from Patent EP1572962.LF317130 - JP 2014500723-A/124633: Polycomb-Associated Non-Coding RNAs.JD252044 - Sequence 233068 from Patent EP1572962.JD354391 - Sequence 335415 from Patent EP1572962.JD358332 - Sequence 339356 from Patent EP1572962.DQ573854 - Homo sapiens piRNA piR-41966, complete sequence.JD293028 - Sequence 274052 from Patent EP1572962.JD281081 - Sequence 262105 from Patent EP1572962.DQ590862 - Homo sapiens piRNA piR-57974, complete sequence.DQ575959 - Homo sapiens piRNA piR-44071, complete sequence.JD477151 - Sequence 458175 from Patent EP1572962.JD287240 - Sequence 268264 from Patent EP1572962.JD343670 - Sequence 324694 from Patent EP1572962.JD316395 - Sequence 297419 from Patent EP1572962.JD290053 - Sequence 271077 from Patent EP1572962.JD491455 - Sequence 472479 from Patent EP1572962.JD311448 - Sequence 292472 from Patent EP1572962.JD489821 - Sequence 470845 from Patent EP1572962.DQ600387 - Homo sapiens piRNA piR-38453, complete sequence.JD477662 - Sequence 458686 from Patent EP1572962.JD560234 - Sequence 541258 from Patent EP1572962.JD208074 - Sequence 189098 from Patent EP1572962.JD361856 - Sequence 342880 from Patent EP1572962.JD241321 - Sequence 222345 from Patent EP1572962.JD084035 - Sequence 65059 from Patent EP1572962.JD517299 - Sequence 498323 from Patent EP1572962.JD274955 - Sequence 255979 from Patent EP1572962.JD224404 - Sequence 205428 from Patent EP1572962.JD280326 - Sequence 261350 from Patent EP1572962.JD295350 - Sequence 276374 from Patent EP1572962.JD092898 - Sequence 73922 from Patent EP1572962.JD184122 - Sequence 165146 from Patent EP1572962.JD066768 - Sequence 47792 from Patent EP1572962.JD176528 - Sequence 157552 from Patent EP1572962.JD205368 - Sequence 186392 from Patent EP1572962.JD552240 - Sequence 533264 from Patent EP1572962.JD266594 - Sequence 247618 from Patent EP1572962.JD291812 - Sequence 272836 from Patent EP1572962.JD422076 - Sequence 403100 from Patent EP1572962.JD422075 - Sequence 403099 from Patent EP1572962.JD286030 - Sequence 267054 from Patent EP1572962.JD429250 - Sequence 410274 from Patent EP1572962.JD247081 - Sequence 228105 from Patent EP1572962.JD247082 - Sequence 228106 from Patent EP1572962.JD413488 - Sequence 394512 from Patent EP1572962.JD467751 - Sequence 448775 from Patent EP1572962.JD072766 - Sequence 53790 from Patent EP1572962.JD241362 - Sequence 222386 from Patent EP1572962.JD195171 - Sequence 176195 from Patent EP1572962.JD247080 - Sequence 228104 from Patent EP1572962.JD225466 - Sequence 206490 from Patent EP1572962.JD195667 - Sequence 176691 from Patent EP1572962.JD143070 - Sequence 124094 from Patent EP1572962.JD040678 - Sequence 21702 from Patent EP1572962.JD309870 - Sequence 290894 from Patent EP1572962.JD227571 - Sequence 208595 from Patent EP1572962.JD172819 - Sequence 153843 from Patent EP1572962.JD537838 - Sequence 518862 from Patent EP1572962.JD184774 - Sequence 165798 from Patent EP1572962.JD443865 - Sequence 424889 from Patent EP1572962.JD060268 - Sequence 41292 from Patent EP1572962.JD559885 - Sequence 540909 from Patent EP1572962.JD184042 - Sequence 165066 from Patent EP1572962.JD451032 - Sequence 432056 from Patent EP1572962.JD381643 - Sequence 362667 from Patent EP1572962.JD280324 - Sequence 261348 from Patent EP1572962.JD277686 - Sequence 258710 from Patent EP1572962.DQ595529 - Homo sapiens piRNA piR-61641, complete sequence.JD023264 - Sequence 4288 from Patent EP1572962.DQ601618 - Homo sapiens piRNA piR-39684, complete sequence.JD028061 - Sequence 9085 from Patent EP1572962.JD200800 - Sequence 181824 from Patent EP1572962.AK311560 - Homo sapiens cDNA, FLJ18602.JD195268 - Sequence 176292 from Patent EP1572962.JD366985 - Sequence 348009 from Patent EP1572962.JD390425 - Sequence 371449 from Patent EP1572962.JD253312 - Sequence 234336 from Patent EP1572962.JD262814 - Sequence 243838 from Patent EP1572962.JD262194 - Sequence 243218 from Patent EP1572962.JD165202 - Sequence 146226 from Patent EP1572962.JD166954 - Sequence 147978 from Patent EP1572962.JD196681 - Sequence 177705 from Patent EP1572962.JD416748 - Sequence 397772 from Patent EP1572962.JD127141 - Sequence 108165 from Patent EP1572962.JD392827 - Sequence 373851 from Patent EP1572962.JD361784 - Sequence 342808 from Patent EP1572962.JD044423 - Sequence 25447 from Patent EP1572962.DQ578539 - Homo sapiens piRNA piR-46651, complete sequence.AY927606 - Homo sapiens mRNA sequence.AY927607 - Homo sapiens mRNA sequence.AY927571 - Homo sapiens mRNA sequence.MA440729 - JP 2018138019-A/12655: Polycomb-Associated Non-Coding RNAs.MA440730 - JP 2018138019-A/12656: Polycomb-Associated Non-Coding RNAs.MA552703 - JP 2018138019-A/124629: Polycomb-Associated Non-Coding RNAs.MA552704 - JP 2018138019-A/124630: Polycomb-Associated Non-Coding RNAs.MA552705 - JP 2018138019-A/124631: Polycomb-Associated Non-Coding RNAs.MA552706 - JP 2018138019-A/124632: Polycomb-Associated Non-Coding RNAs.MA552707 - JP 2018138019-A/124633: Polycomb-Associated Non-Coding RNAs.JD289394 - Sequence 270418 from Patent EP1572962.JD540141 - Sequence 521165 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: A8K6T6, ENST00000182527.1, ENST00000182527.2, ENST00000182527.3, KIAA0057, NM_012288, Q15035, TRAM2_HUMAN, uc317cfh.1, uc317cfh.2UCSC ID: ENST00000182527.4_7RefSeq Accession: NM_012288.4 Protein: Q15035
(aka TRAM2_HUMAN or TAM2_HUMAN)
Gene Model Information
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for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
