Human Gene TRIM35 (ENST00000305364.9_7) from GENCODE V47lift37

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Description: tripartite motif containing 35, transcript variant 1 (from RefSeq NM_171982.5)
Gencode Transcript: ENST00000305364.9_7
Gencode Gene: ENSG00000104228.13_9
Transcript (Including UTRs)
Position: hg19 chr8:27,142,403-27,168,789 Size: 26,387 Total Exon Count: 6 Strand: -
Coding Region
Position: hg19 chr8:27,145,067-27,168,752 Size: 23,686 Coding Exon Count: 6

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions
Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr8:27,142,403-27,168,789)			mRNA (may differ from genome)		Protein (493 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	Reactome	UniProtKB
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: TRI35_HUMAN DESCRIPTION: RecName: Full=Tripartite motif-containing protein 35; AltName: Full=Hemopoietic lineage switch protein 5; FUNCTION: May play a role as a tumor suppressor. Implicated in the cell death mechanism (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Found predominantly in cytoplasm with a granular distribution. Found in punctuate nuclear bodies (By similarity). DOMAIN: The RING finger domain and the coiled-coil region are required for the apoptosis-inducing activity (By similarity). SIMILARITY: Belongs to the TRIM/RBCC family. SIMILARITY: Contains 1 B box-type zinc finger. SIMILARITY: Contains 1 B30.2/SPRY domain. SIMILARITY: Contains 1 RING-type zinc finger. SEQUENCE CAUTION: Sequence=BAA83050.1; Type=Erroneous initiation;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D001564 Benzo(a)pyrene D000082 Acetaminophen D002794 Choline D016572 Cyclosporine D003993 Dibutyl Phthalate D004052 Diethylnitrosamine D005492 Folic Acid D005839 Gentamicins D008715 Methionine D018038 Sodium Selenite more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 22.98 RPKM in Skin - Sun Exposed (Lower leg) Total median expression: 283.94 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-12.40	37	-0.335	Picture	PostScript	Text
3' UTR	-845.40	2664	-0.317	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR001870 - B30.2/SPRY
IPR003879 - Butyrophylin
IPR008985 - ConA-like_lec_gl_sf
IPR006574 - PRY
IPR003877 - SPRY_rcpt
IPR000315 - Znf_B-box
IPR001841 - Znf_RING
IPR013083 - Znf_RING/FYVE/PHD
IPR017907 - Znf_RING_CS

Pfam Domains:
PF00097 - Zinc finger, C3HC4 type (RING finger)
PF00622 - SPRY domain
PF00643 - B-box zinc finger
PF13445 - RING-type zinc-finger
PF13639 - Ring finger domain
PF13765 - SPRY-associated domain
PF13920 - Zinc finger, C3HC4 type (RING finger)
PF13923 - Zinc finger, C3HC4 type (RING finger)

SCOP Domains:
49899 - Concanavalin A-like lectins/glucanases
57845 - B-box zinc-binding domain
57850 - RING/U-box

ModBase Predicted Comparative 3D Structure on Q9UPQ4


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003674 molecular_function GO:0008270 zinc ion binding GO:0046872 metal ion binding Biological Process: GO:0006915 apoptotic process GO:0043065 positive regulation of apoptotic process GO:0045087 innate immune response GO:0045930 negative regulation of mitotic cell cycle GO:1902187 negative regulation of viral release from host cell Cellular Component: GO:0005622 intracellular GO:0005634 nucleus GO:0005737 cytoplasm

Descriptions from all associated GenBank mRNAs


	AB029021 - Homo sapiens KIAA1098 mRNA for KIAA1098 protein. AF492463 - Homo sapiens hemopoeitic lineage switch gene 5 (HLS5) mRNA, complete cds. JD244532 - Sequence 225556 from Patent EP1572962. JD297382 - Sequence 278406 from Patent EP1572962. JD545588 - Sequence 526612 from Patent EP1572962. BC069226 - Homo sapiens tripartite motif-containing 35, mRNA (cDNA clone MGC:78391 IMAGE:6428667), complete cds. JD312433 - Sequence 293457 from Patent EP1572962. JD111532 - Sequence 92556 from Patent EP1572962. JD082096 - Sequence 63120 from Patent EP1572962. JD378191 - Sequence 359215 from Patent EP1572962. JD298786 - Sequence 279810 from Patent EP1572962. JD093778 - Sequence 74802 from Patent EP1572962. JD287887 - Sequence 268911 from Patent EP1572962. DQ580023 - Homo sapiens piRNA piR-48135, complete sequence. JD259571 - Sequence 240595 from Patent EP1572962. JD548255 - Sequence 529279 from Patent EP1572962. JD154273 - Sequence 135297 from Patent EP1572962. JD392360 - Sequence 373384 from Patent EP1572962. JD192542 - Sequence 173566 from Patent EP1572962. JD427484 - Sequence 408508 from Patent EP1572962. JD222828 - Sequence 203852 from Patent EP1572962. JD299860 - Sequence 280884 from Patent EP1572962. JD148046 - Sequence 129070 from Patent EP1572962. BC018337 - Homo sapiens tripartite motif-containing 35, mRNA (cDNA clone IMAGE:4215244), complete cds. JD319792 - Sequence 300816 from Patent EP1572962. JD235562 - Sequence 216586 from Patent EP1572962. JD556096 - Sequence 537120 from Patent EP1572962. JD257610 - Sequence 238634 from Patent EP1572962. JD351997 - Sequence 333021 from Patent EP1572962. JD183793 - Sequence 164817 from Patent EP1572962. JD453334 - Sequence 434358 from Patent EP1572962. JD508438 - Sequence 489462 from Patent EP1572962. JD287794 - Sequence 268818 from Patent EP1572962. JD524837 - Sequence 505861 from Patent EP1572962. JD309742 - Sequence 290766 from Patent EP1572962. JD305514 - Sequence 286538 from Patent EP1572962. JD073520 - Sequence 54544 from Patent EP1572962. JD043519 - Sequence 24543 from Patent EP1572962. JD277688 - Sequence 258712 from Patent EP1572962. JD091002 - Sequence 72026 from Patent EP1572962. JD394146 - Sequence 375170 from Patent EP1572962. JD226788 - Sequence 207812 from Patent EP1572962. JD377441 - Sequence 358465 from Patent EP1572962. JD554361 - Sequence 535385 from Patent EP1572962. JD404143 - Sequence 385167 from Patent EP1572962. JD136532 - Sequence 117556 from Patent EP1572962. JD392828 - Sequence 373852 from Patent EP1572962. JD559010 - Sequence 540034 from Patent EP1572962. JD061414 - Sequence 42438 from Patent EP1572962. JD296358 - Sequence 277382 from Patent EP1572962. JD111147 - Sequence 92171 from Patent EP1572962. AB384113 - Synthetic construct DNA, clone: pF1KSDA1098, Homo sapiens TRIM35 gene for tripartite motif-containing protein 35, complete cds, without stop codon, in Flexi system. EU446781 - Synthetic construct Homo sapiens clone IMAGE:100070127; IMAGE:100011990; FLH258157.01L tripartite motif-containing 35 (TRIM35) gene, encodes complete protein. JD381592 - Sequence 362616 from Patent EP1572962. AK308236 - Homo sapiens cDNA, FLJ98184. JD496643 - Sequence 477667 from Patent EP1572962. JD452255 - Sequence 433279 from Patent EP1572962. JD325471 - Sequence 306495 from Patent EP1572962. JD174263 - Sequence 155287 from Patent EP1572962. JD485096 - Sequence 466120 from Patent EP1572962. JD201096 - Sequence 182120 from Patent EP1572962. JD239901 - Sequence 220925 from Patent EP1572962. JD224489 - Sequence 205513 from Patent EP1572962. JD339530 - Sequence 320554 from Patent EP1572962. JD235945 - Sequence 216969 from Patent EP1572962. KJ902278 - Synthetic construct Homo sapiens clone ccsbBroadEn_11672 TRIM35 gene, encodes complete protein.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q9UPQ4 (Reactome details) participates in the following event(s): R-HSA-877300 Interferon gamma signaling R-HSA-913531 Interferon Signaling R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-168256 Immune System

Other Names for This Gene


	Alternate Gene Symbols: ENST00000305364.1, ENST00000305364.2, ENST00000305364.3, ENST00000305364.4, ENST00000305364.5, ENST00000305364.6, ENST00000305364.7, ENST00000305364.8, HLS5, KIAA1098, NM_171982, Q86XQ0, Q8WVA4, Q9UPQ4, TRI35_HUMAN, uc317nps.1, uc317nps.2 UCSC ID: ENST00000305364.9_7 RefSeq Accession: NM_171982.5 Protein: Q9UPQ4 (aka TRI35_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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