ID:TRIPB_HUMAN DESCRIPTION: RecName: Full=Thyroid receptor-interacting protein 11; Short=TR-interacting protein 11; Short=TRIP-11; AltName: Full=Clonal evolution-related gene on chromosome 14 protein; AltName: Full=Golgi-associated microtubule-binding protein 210; Short=GMAP-210; AltName: Full=Trip230; FUNCTION: Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB- modulated transcription. Golgi auto-antigen; probably involved in maintaining cis-Golgi structure. SUBUNIT: Binds RB1. SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Associates with the ends of centrosome-nucleated microtubules. TISSUE SPECIFICITY: Highly expressed in pancreas, muscle, heart, testis, peripheral blood leukocytes, and in several leukemia cell lines. Detected at intermediate levels in placenta and kidney, and at low levels in brain and lung. DOMAIN: Extended rod-like protein with coiled-coil domains. DISEASE: Note=A chromosomal aberration involving TRIP11 may be a cause of acute myelogenous leukemia. Translocation t(5;14)(q33;q32) with PDGFRB. The fusion protein may be involved in clonal evolution of leukemia and eosinophilia. DISEASE: Defects in TRIP11 are the cause of achondrogenesis type 1A (ACG1A) [MIM:200600]. A form of achondrogenesis type 1, a lethal form of chondrodysplasia characterized by deficient ossification in the lumbar vertebrae and absent ossification in the sacral, pubic and ischial bones and clinically by stillbirth or early death. In addition to severe micromelia, there is a disproportionately large cranium due to marked edema of soft tissues. SIMILARITY: Contains 1 GRIP domain. SEQUENCE CAUTION: Sequence=AAB84386.1; Type=Frameshift; Positions=1932, 1955; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CEV14.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q15643
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003713 transcription coactivator activity GO:0005515 protein binding
Biological Process: GO:0003281 ventricular septum development GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis GO:0006366 transcription from RNA polymerase II promoter GO:0006486 protein glycosylation GO:0007030 Golgi organization GO:0035735 intraciliary transport involved in cilium assembly GO:0060122 inner ear receptor stereocilium organization GO:0060348 bone development
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
