Human Gene TTF2 (ENST00000369466.9_4) from GENCODE V47lift37
  Description: transcription termination factor 2 (from RefSeq NM_003594.4)
Gencode Transcript: ENST00000369466.9_4
Gencode Gene: ENSG00000116830.12_10
Transcript (Including UTRs)
   Position: hg19 chr1:117,602,948-117,650,075 Size: 47,128 Total Exon Count: 23 Strand: +
Coding Region
   Position: hg19 chr1:117,602,969-117,644,146 Size: 41,178 Coding Exon Count: 23 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:117,602,948-117,650,075)mRNA (may differ from genome)Protein (1162 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TTF2_HUMAN
DESCRIPTION: RecName: Full=Transcription termination factor 2; EC=3.6.4.-; AltName: Full=Lodestar homolog; AltName: Full=RNA polymerase II termination factor; AltName: Full=Transcription release factor 2; Short=F2; Short=HuF2;
FUNCTION: DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing.
SUBUNIT: Interacts with CDC5L. Part of the spliceosome.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Cytoplasmic during interphase. Relocates to the nucleus as cells enter mitosis.
SIMILARITY: Belongs to the SNF2/RAD54 helicase family.
SIMILARITY: Contains 1 helicase ATP-binding domain.
SIMILARITY: Contains 1 helicase C-terminal domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: TTF2
Diseases sorted by gene-association score: sexual sadism (16), narcissistic personality disorder (8), brunner syndrome (8), axenfeld-rieger syndrome (6)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.89 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 84.80 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -4.1021-0.195 Picture PostScript Text
3' UTR -1777.405929-0.300 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002464 - DNA/RNA_helicase_DEAH_CS
IPR014001 - Helicase_ATP-bd
IPR001650 - Helicase_C
IPR000330 - SNF2_N
IPR010666 - Znf_GRF

Pfam Domains:
PF00176 - SNF2-related domain
PF00271 - Helicase conserved C-terminal domain
PF04851 - Type III restriction enzyme, res subunit
PF06839 - GRF zinc finger

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on Q9UNY4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
Gene SorterGene Sorter Gene SorterGene Sorter 
 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008094 DNA-dependent ATPase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006353 DNA-templated transcription, termination
GO:0006355 regulation of transcription, DNA-templated
GO:0006369 termination of RNA polymerase II transcription
GO:0006397 mRNA processing
GO:0008380 RNA splicing

Cellular Component:
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0008023 transcription elongation factor complex


-  Descriptions from all associated GenBank mRNAs
  AK291017 - Homo sapiens cDNA FLJ75070 complete cds, highly similar to Homo sapiens transcription termination factor, RNA polymerase II(TTF2), mRNA.
LF206259 - JP 2014500723-A/13762: Polycomb-Associated Non-Coding RNAs.
AF073771 - Homo sapiens RNA polymerase II termination factor mRNA, complete cds.
AF080255 - Homo sapiens lodestar protein mRNA, complete cds.
BC015341 - Homo sapiens cDNA clone IMAGE:4431381, containing frame-shift errors.
BC030058 - Homo sapiens transcription termination factor, RNA polymerase II, mRNA (cDNA clone MGC:39244 IMAGE:5457833), complete cds.
KJ901881 - Synthetic construct Homo sapiens clone ccsbBroadEn_11275 TTF2 gene, encodes complete protein.
LF352765 - JP 2014500723-A/160268: Polycomb-Associated Non-Coding RNAs.
LF352762 - JP 2014500723-A/160265: Polycomb-Associated Non-Coding RNAs.
LF352761 - JP 2014500723-A/160264: Polycomb-Associated Non-Coding RNAs.
LF352758 - JP 2014500723-A/160261: Polycomb-Associated Non-Coding RNAs.
AB209845 - Homo sapiens mRNA for transcription termination factor, RNA polymerase II variant protein.
LF352754 - JP 2014500723-A/160257: Polycomb-Associated Non-Coding RNAs.
JD463366 - Sequence 444390 from Patent EP1572962.
JD296931 - Sequence 277955 from Patent EP1572962.
JD246362 - Sequence 227386 from Patent EP1572962.
JD063463 - Sequence 44487 from Patent EP1572962.
JD543276 - Sequence 524300 from Patent EP1572962.
JD478590 - Sequence 459614 from Patent EP1572962.
JD463836 - Sequence 444860 from Patent EP1572962.
JD148325 - Sequence 129349 from Patent EP1572962.
JD249882 - Sequence 230906 from Patent EP1572962.
JD471807 - Sequence 452831 from Patent EP1572962.
JD471596 - Sequence 452620 from Patent EP1572962.
JD557664 - Sequence 538688 from Patent EP1572962.
JD530306 - Sequence 511330 from Patent EP1572962.
JD436844 - Sequence 417868 from Patent EP1572962.
JD511561 - Sequence 492585 from Patent EP1572962.
JD043147 - Sequence 24171 from Patent EP1572962.
JD166791 - Sequence 147815 from Patent EP1572962.
JD117105 - Sequence 98129 from Patent EP1572962.
JD277615 - Sequence 258639 from Patent EP1572962.
JD482662 - Sequence 463686 from Patent EP1572962.
JD472480 - Sequence 453504 from Patent EP1572962.
JD472479 - Sequence 453503 from Patent EP1572962.
JD533103 - Sequence 514127 from Patent EP1572962.
JD178664 - Sequence 159688 from Patent EP1572962.
JD206878 - Sequence 187902 from Patent EP1572962.
JD086196 - Sequence 67220 from Patent EP1572962.
JD229255 - Sequence 210279 from Patent EP1572962.
JD268508 - Sequence 249532 from Patent EP1572962.
JD184216 - Sequence 165240 from Patent EP1572962.
JD093099 - Sequence 74123 from Patent EP1572962.
JD561456 - Sequence 542480 from Patent EP1572962.
JD282027 - Sequence 263051 from Patent EP1572962.
JD230148 - Sequence 211172 from Patent EP1572962.
JD269750 - Sequence 250774 from Patent EP1572962.
JD428735 - Sequence 409759 from Patent EP1572962.
JD551251 - Sequence 532275 from Patent EP1572962.
JD543061 - Sequence 524085 from Patent EP1572962.
JD257751 - Sequence 238775 from Patent EP1572962.
JD481369 - Sequence 462393 from Patent EP1572962.
JD179711 - Sequence 160735 from Patent EP1572962.
AK123765 - Homo sapiens cDNA FLJ41771 fis, clone IMR322009807.
MA588342 - JP 2018138019-A/160268: Polycomb-Associated Non-Coding RNAs.
MA588339 - JP 2018138019-A/160265: Polycomb-Associated Non-Coding RNAs.
MA588338 - JP 2018138019-A/160264: Polycomb-Associated Non-Coding RNAs.
MA588335 - JP 2018138019-A/160261: Polycomb-Associated Non-Coding RNAs.
MA588331 - JP 2018138019-A/160257: Polycomb-Associated Non-Coding RNAs.
MA441836 - JP 2018138019-A/13762: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K4Q2, ENST00000369466.1, ENST00000369466.2, ENST00000369466.3, ENST00000369466.4, ENST00000369466.5, ENST00000369466.6, ENST00000369466.7, ENST00000369466.8, NM_003594, O75921, Q5T2K7, Q5VVU8, Q8N6I8, Q9UNY4, TTF2_HUMAN, uc318hoz.1, uc318hoz.2
UCSC ID: ENST00000369466.9_4
RefSeq Accession: NM_003594.4
Protein: Q9UNY4 (aka TTF2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.