ID:UB2J2_HUMAN DESCRIPTION: RecName: Full=Ubiquitin-conjugating enzyme E2 J2; EC=6.3.2.19; AltName: Full=Non-canonical ubiquitin-conjugating enzyme 2; Short=NCUBE-2; FUNCTION: Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD) (By similarity). CATALYTIC ACTIVITY: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. PATHWAY: Protein modification; protein ubiquitination. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type IV membrane protein (By similarity). SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8N2K1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000166 nucleotide binding GO:0005524 ATP binding GO:0016740 transferase activity GO:0031625 ubiquitin protein ligase binding GO:0061630 ubiquitin protein ligase activity GO:0061631 ubiquitin conjugating enzyme activity
Biological Process: GO:0000209 protein polyubiquitination GO:0006986 response to unfolded protein GO:0016567 protein ubiquitination GO:0030433 ER-associated ubiquitin-dependent protein catabolic process GO:1903955 positive regulation of protein targeting to mitochondrion
BC094777 - Homo sapiens ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast), mRNA (cDNA clone MGC:104681 IMAGE:30340049), complete cds. AK098803 - Homo sapiens cDNA FLJ25937 fis, clone JTH07151. AK056065 - Homo sapiens cDNA FLJ31503 fis, clone NT2NE2005720, highly similar to Mus musculus Ubc6p homolog mRNA. BC027728 - Homo sapiens ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast), mRNA (cDNA clone IMAGE:4645540), partial cds. BC052579 - Homo sapiens ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast), mRNA (cDNA clone IMAGE:5015170), partial cds. AF116687 - Homo sapiens PRO2121 mRNA, complete cds. JD076536 - Sequence 57560 from Patent EP1572962. JD472144 - Sequence 453168 from Patent EP1572962. JD394726 - Sequence 375750 from Patent EP1572962. JD476389 - Sequence 457413 from Patent EP1572962. JD057181 - Sequence 38205 from Patent EP1572962. JD173399 - Sequence 154423 from Patent EP1572962. JD191956 - Sequence 172980 from Patent EP1572962. JD126199 - Sequence 107223 from Patent EP1572962. JD436901 - Sequence 417925 from Patent EP1572962. JD216319 - Sequence 197343 from Patent EP1572962. JD425757 - Sequence 406781 from Patent EP1572962. AK075017 - Homo sapiens cDNA FLJ90536 fis, clone OVARC1000105, highly similar to Ubiquitin conjugating enzyme E2. JD192407 - Sequence 173431 from Patent EP1572962. JD271022 - Sequence 252046 from Patent EP1572962. JD230455 - Sequence 211479 from Patent EP1572962. JD380124 - Sequence 361148 from Patent EP1572962. JD427117 - Sequence 408141 from Patent EP1572962. JD466781 - Sequence 447805 from Patent EP1572962. JD276749 - Sequence 257773 from Patent EP1572962. JD521315 - Sequence 502339 from Patent EP1572962. BC113430 - Homo sapiens ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast), mRNA (cDNA clone MGC:141990 IMAGE:8322482), complete cds. BC143657 - Homo sapiens ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast), mRNA (cDNA clone MGC:177188 IMAGE:9052171), complete cds. AK291935 - Homo sapiens cDNA FLJ77503 complete cds, highly similar to Homo sapiens ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast) (UBE2J2), transcript variant 2, mRNA. BC104890 - Homo sapiens ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast), mRNA (cDNA clone MGC:132550 IMAGE:8143893), complete cds. AF296658 - Homo sapiens ubiquitin conjugating enzyme 6 mRNA, complete cds. JD167494 - Sequence 148518 from Patent EP1572962. JD540600 - Sequence 521624 from Patent EP1572962. HQ258753 - Synthetic construct Homo sapiens clone IMAGE:100072783 ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast) (UBE2J2), transcript variant 2 (UBE2J2) gene, encodes complete protein. KJ895335 - Synthetic construct Homo sapiens clone ccsbBroadEn_04729 UBE2J2 gene, encodes complete protein. KJ900056 - Synthetic construct Homo sapiens clone ccsbBroadEn_09450 UBE2J2 gene, encodes complete protein.
Biochemical and Signaling Pathways
BioCyc Knowledge Library PWY-7511 - protein ubiquitination
Reactome (by CSHL, EBI, and GO)
Protein Q8N2K1 (Reactome details) participates in the following event(s):
R-HSA-983152 Transfer of ubiquitin from E1 to E2 R-HSA-983140 Transfer of Ub from E2 to substrate and release of E2 R-HSA-983157 Interaction of E3 with substrate and E2-Ub complex R-HSA-8943083 US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation R-HSA-8852135 Protein ubiquitination R-HSA-983169 Class I MHC mediated antigen processing & presentation R-HSA-597592 Post-translational protein modification R-HSA-1280218 Adaptive Immune System R-HSA-392499 Metabolism of proteins R-HSA-168256 Immune System
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
