Human Gene WDR25 (ENST00000402312.8_3) from GENCODE V47lift37
  Description: WD repeat domain 25, transcript variant 7 (from RefSeq NM_001387351.1)
Gencode Transcript: ENST00000402312.8_3
Gencode Gene: ENSG00000176473.14_7
Transcript (Including UTRs)
   Position: hg19 chr14:100,842,822-100,996,640 Size: 153,819 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr14:100,847,262-100,996,378 Size: 149,117 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:100,842,822-100,996,640)mRNA (may differ from genome)Protein (544 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblExonPrimerGeneCardsHGNC
MGIPubMedUniProtKB

-  Comments and Description Text from UniProtKB
  ID: WDR25_HUMAN
DESCRIPTION: RecName: Full=WD repeat-containing protein 25;
TISSUE SPECIFICITY: Expressed in heart, muscle, testis, ovary, uterus and prostate.
SIMILARITY: Contains 7 WD repeats.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 4.46 RPKM in Pituitary
Total median expression: 124.61 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -3.6026-0.138 Picture PostScript Text
3' UTR -87.90262-0.335 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR015943 - WD40/YVTN_repeat-like_dom
IPR001680 - WD40_repeat
IPR017986 - WD40_repeat_dom

Pfam Domains:
PF00400 - WD domain, G-beta repeat

SCOP Domains:
50952 - Soluble quinoprotein glucose dehydrogenase
50960 - TolB, C-terminal domain
63825 - YWTD domain
63829 - Calcium-dependent phosphotriesterase
69304 - Tricorn protease N-terminal domain
101898 - NHL repeat
50965 - Galactose oxidase, central domain
75011 - 3-carboxy-cis,cis-mucoante lactonizing enzyme
101908 - Putative isomerase YbhE
117289 - Nucleoporin domain
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50974 - Nitrous oxide reductase, N-terminal domain
50978 - WD40 repeat-like
50993 - Peptidase/esterase 'gauge' domain
69322 - Tricorn protease domain 2
50998 - Quinoprotein alcohol dehydrogenase-like
51004 - C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase
82171 - DPP6 N-terminal domain-like

ModBase Predicted Comparative 3D Structure on Q64LD2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding


-  Descriptions from all associated GenBank mRNAs
  AK291960 - Homo sapiens cDNA FLJ76429 complete cds, highly similar to Homo sapiens WD repeat domain 25 (WDR25), mRNA.
GQ891526 - Homo sapiens clone HEL-S-247 epididymis secretory sperm binding protein mRNA, complete cds.
AY295082 - Homo sapiens pre-mRNA splicing factor-like protein mRNA, complete cds.
BC007953 - Homo sapiens WD repeat domain 25, mRNA (cDNA clone IMAGE:4299080).
BC003641 - Homo sapiens WD repeat domain 25, mRNA (cDNA clone MGC:4645 IMAGE:3529568), complete cds.
CU678554 - Synthetic construct Homo sapiens gateway clone IMAGE:100018740 5' read WDR25 mRNA.
KJ903173 - Synthetic construct Homo sapiens clone ccsbBroadEn_12567 WDR25 gene, encodes complete protein.
BX248767 - human full-length cDNA 5-PRIME end of clone CS0DD009YE24 of Neuroblastoma of Homo sapiens (human).
BC067872 - Homo sapiens WD repeat domain 25, mRNA (cDNA clone IMAGE:30338475).
JD119512 - Sequence 100536 from Patent EP1572962.
JD328261 - Sequence 309285 from Patent EP1572962.
JD177606 - Sequence 158630 from Patent EP1572962.
JD438594 - Sequence 419618 from Patent EP1572962.
JD052563 - Sequence 33587 from Patent EP1572962.
JD435115 - Sequence 416139 from Patent EP1572962.
JD297826 - Sequence 278850 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K7E5, C14orf67 , ENST00000402312.1, ENST00000402312.2, ENST00000402312.3, ENST00000402312.4, ENST00000402312.5, ENST00000402312.6, ENST00000402312.7, NM_001387351, Q64LD2, Q6NVV6, Q86TQ4, Q9BTK5, uc319btg.1, uc319btg.2, WDR25 , WDR25_HUMAN
UCSC ID: ENST00000402312.8_3
RefSeq Accession: NM_001161476.3
Protein: Q64LD2 (aka WDR25_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.