ID:NSD3_HUMAN DESCRIPTION: RecName: Full=Histone-lysine N-methyltransferase NSD3; EC=2.1.1.43; AltName: Full=Nuclear SET domain-containing protein 3; AltName: Full=Protein whistle; AltName: Full=WHSC1-like 1 isoform 9 with methyltransferase activity to lysine; AltName: Full=Wolf-Hirschhorn syndrome candidate 1-like protein 1; Short=WHSC1-like protein 1; FUNCTION: Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. SUBCELLULAR LOCATION: Nucleus (By similarity). Chromosome (By similarity). TISSUE SPECIFICITY: Highly expressed in brain, heart and skeletal muscle. Expressed at lower level in liver and lung. DISEASE: Note=Defects in WHSC1L1 may be involved in non small cell lung carcinomas (NSCLC). Amplified or overexpressed in NSCLC. DISEASE: Note=A chromosomal aberration involving WHSC1L1 is found in childhood acute myeloid leukemia. Translocation t(8;11)(p11.2;p15) with NUP98. SIMILARITY: Belongs to the histone-lysine methyltransferase family. SET2 subfamily. SIMILARITY: Contains 1 AWS domain. SIMILARITY: Contains 4 PHD-type zinc fingers. SIMILARITY: Contains 1 post-SET domain. SIMILARITY: Contains 2 PWWP domains. SIMILARITY: Contains 1 SET domain. SEQUENCE CAUTION: Sequence=AAG44637.1; Type=Frameshift; Positions=Several; Sequence=AAI07735.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAA91110.1; Type=Erroneous initiation; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/WHSC1L1NSD3ID42810ch8p11.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BZ95
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
