Human Gene WIF1 (ENST00000286574.9_7) from GENCODE V48lift37
Description: WNT inhibitory factor 1 (from RefSeq NM_007191.5)
Gencode Transcript: ENST00000286574.9_7
Gencode Gene: ENSG00000156076.10_10
Transcript (Including UTRs)
Position: hg19 chr12:65,444,406-65,515,085 Size: 70,680 Total Exon Count: 10 Strand: -
Coding Region
Position: hg19 chr12:65,445,129-65,514,971 Size: 69,843 Coding Exon Count: 10
Data last updated at UCSC: 2025-04-10 15:10:12
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: WIF1_HUMAN
DESCRIPTION: RecName: Full=Wnt inhibitory factor 1; Short=WIF-1; Flags: Precursor;
FUNCTION: Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.SUBCELLULAR LOCATION: Secreted.SIMILARITY: Contains 5 EGF-like domains.SIMILARITY: Contains 1 WIF domain.
Primer design for this transcript
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR000742 - EG-like_dom
IPR013032 - EGF-like_CS
IPR003306 - WIF
IPR013309 - Wnt-inh
Pfam Domains: PF02019 - WIF domain
PF12661 - Human growth factor-like EGF
SCOP Domains: 57196 - EGF/Laminin
57184 - Growth factor receptor domain
Protein Data Bank (PDB) 3-D Structure MuPIT help
ModBase Predicted Comparative 3D Structure on Q9Y5W5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
EF058195 - Homo sapiens HMGA2/WIF1 fusion protein mRNA, partial cds.BX647427 - Homo sapiens mRNA; cDNA DKFZp686J0699 (from clone DKFZp686J0699).AF122922 - Homo sapiens Wnt inhibitory factor-1 mRNA, complete cds.AY358344 - Homo sapiens clone DNA33094 WIF-1 (UNQ191) mRNA, complete cds.BC018037 - Homo sapiens WNT inhibitory factor 1, mRNA (cDNA clone MGC:26240 IMAGE:4801033), complete cds.JD019172 - Sequence 196 from Patent EP1572962.JD168120 - Sequence 149144 from Patent EP1572962.JD032994 - Sequence 14018 from Patent EP1572962.AK301818 - Homo sapiens cDNA FLJ54458 complete cds, highly similar to Wnt inhibitory factor 1 precursor.JD235482 - Sequence 216506 from Patent EP1572962.JD258121 - Sequence 239145 from Patent EP1572962.JD286189 - Sequence 267213 from Patent EP1572962.JD546137 - Sequence 527161 from Patent EP1572962.KJ898375 - Synthetic construct Homo sapiens clone ccsbBroadEn_07769 WIF1 gene, encodes complete protein.DQ892394 - Synthetic construct clone IMAGE:100005024; FLH185931.01X; RZPDo839G10148D WNT inhibitory factor 1 (WIF1) gene, encodes complete protein.DQ895609 - Synthetic construct Homo sapiens clone IMAGE:100010069; FLH185927.01L; RZPDo839G10147D WNT inhibitory factor 1 (WIF1) gene, encodes complete protein.EU263623 - Homo sapiens HMGA2ex3/WIF1ex10 fusion protein (HMGA2/WIF1 fusion) mRNA, partial cds.EU263622 - Homo sapiens HMGA2ex3/WIF1ex9 fusion protein (HMGA2/WIF1 fusion) mRNA, partial cds.EU263621 - Homo sapiens HMGA2ex3/WIF1ex4 fusion protein (HMGA2/WIF1 fusion) mRNA, partial cds.EU263620 - Homo sapiens HMGA2ex5/WIF1ex3 fusion protein (HMGA2/WIF1 fusion) mRNA, partial cds.EU263619 - Homo sapiens HMGA2ex3/WIF1ex3 fusion protein (HMGA2/WIF1 fusion) mRNA, partial cds.JD307541 - Sequence 288565 from Patent EP1572962.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: ENST00000286574.1, ENST00000286574.2, ENST00000286574.3, ENST00000286574.4, ENST00000286574.5, ENST00000286574.6, ENST00000286574.7, ENST00000286574.8, NM_007191, Q6UXI1, Q8WVG4, Q9Y5W5, uc317kkl.1, uc317kkl.2, UNQ191/PRO217, WIF1_HUMANUCSC ID: ENST00000286574.9_7RefSeq Accession: NM_007191.5
Protein: Q9Y5W5
(aka WIF1_HUMAN)
Gene Model Information
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.