Human Gene XAGE2 (ENST00000286049.3_4) from GENCODE V48lift37

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Description: X antigen family member 2 (from RefSeq NM_130777.3)
Gencode Transcript: ENST00000286049.3_4
Gencode Gene: ENSG00000155622.7_7
Transcript (Including UTRs)
Position: hg19 chrX:52,112,164-52,118,823 Size: 6,660 Total Exon Count: 5 Strand: +
Coding Region
Position: hg19 chrX:52,113,158-52,118,734 Size: 5,577 Coding Exon Count: 4

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2025-04-10 15:10:12

Sequence and Links to Tools and Databases

Genomic Sequence (chrX:52,112,164-52,118,823)			mRNA (may differ from genome)		Protein (111 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
Malacards	MGI	neXtProt	OMIM	PubMed	UniProtKB
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: GAGD3_HUMAN DESCRIPTION: RecName: Full=G antigen family D member 3; AltName: Full=Cancer/testis antigen 12.2; Short=CT12.2; AltName: Full=Protein XAGE-2; SIMILARITY: Belongs to the GAGE family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: XAGE2 Diseases sorted by gene-association score: ewing sarcoma (3)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D001104 Arbutin D004397 Fonofos D010278 Parathion D018038 Sodium Selenite C018021 cobaltous chloride C012568 terbufos

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 0.00 RPKM in (null) Total median expression: 0.00 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-66.90	202	-0.331	Picture	PostScript	Text
3' UTR	-19.30	89	-0.217	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR008625 - GAGE

Pfam Domains:
PF05831 - GAGE protein

ModBase Predicted Comparative 3D Structure on Q96GT9


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005515 protein binding

Descriptions from all associated GenBank mRNAs


	JD269101 - Sequence 250125 from Patent EP1572962. BC066311 - Homo sapiens X antigen family, member 2, mRNA (cDNA clone MGC:87153 IMAGE:30330532), complete cds. BC009232 - Homo sapiens X antigen family, member 2, mRNA (cDNA clone MGC:16513 IMAGE:3960352), complete cds. AJ318880 - Homo sapiens mRNA for XAGE-2 protein. JD057031 - Sequence 38055 from Patent EP1572962. JD487642 - Sequence 468666 from Patent EP1572962. DQ896442 - Synthetic construct Homo sapiens clone IMAGE:100010902; FLH194338.01L; RZPDo839A0470D X antigen family, member 2 (XAGE2) gene, encodes complete protein. AB590383 - Synthetic construct DNA, clone: pFN21AE1109, Homo sapiens XAGE2 gene for X antigen family, member 2, without stop codon, in Flexi system. DQ893147 - Synthetic construct clone IMAGE:100005777; FLH194342.01X; RZPDo839A0480D X antigen family, member 2 (XAGE2) gene, encodes complete protein. KJ892783 - Synthetic construct Homo sapiens clone ccsbBroadEn_02177 XAGE2 gene, encodes complete protein. KJ898038 - Synthetic construct Homo sapiens clone ccsbBroadEn_07432 XAGE2 gene, encodes complete protein.

Other Names for This Gene


	Alternate Gene Symbols: ENST00000286049.1, ENST00000286049.2, GAGED3, NM_130777, Q5HYR4, Q96GT9, uc317kix.1, uc317kix.2, XAGE2B, XAGE2_HUMAN UCSC ID: ENST00000286049.3_4 RefSeq Accession: NM_130777.3 Protein: Q96GT9 (aka GAGD3_HUMAN or GGD3_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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