Human Gene TUT7 (ENST00000375960.6_5) from GENCODE V47lift37
  Description: terminal uridylyl transferase 7, transcript variant 3 (from RefSeq NM_001185074.2)
Gencode Transcript: ENST00000375960.6_5
Gencode Gene: ENSG00000083223.18_9
Transcript (Including UTRs)
   Position: hg19 chr9:88,902,648-88,969,369 Size: 66,722 Total Exon Count: 20 Strand: -
Coding Region
   Position: hg19 chr9:88,903,592-88,968,114 Size: 64,523 Coding Exon Count: 19 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:88,902,648-88,969,369)mRNA (may differ from genome)Protein (1259 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
OMIMPubMedReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TUT7_HUMAN
DESCRIPTION: RecName: Full=Terminal uridylyltransferase 7; Short=TUTase 7; EC=2.7.7.52; AltName: Full=Zinc finger CCHC domain-containing protein 6;
FUNCTION: Uridylyltransferase that mediates the terminal uridylation of some specific RNAs. Not involved in uridylation of precursor let-7 (pre-let-7) miRNA. Does not play a role in replication-dependent histone mRNA degradation.
CATALYTIC ACTIVITY: UTP + RNA(n) = diphosphate + RNA(n+1).
COFACTOR: Magnesium or manganese (By similarity).
SIMILARITY: Belongs to the DNA polymerase type-B-like family.
SIMILARITY: Contains 3 CCHC-type zinc fingers.
SIMILARITY: Contains 2 PAP-associated domains.
SEQUENCE CAUTION: Sequence=BAB14584.1; Type=Erroneous initiation; Sequence=BAB71052.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 14.26 RPKM in Skin - Sun Exposed (Lower leg)
Total median expression: 252.86 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -82.50215-0.384 Picture PostScript Text
3' UTR -225.70944-0.239 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002058 - PAP_assoc
IPR001878 - Znf_CCHC

Pfam Domains:
PF00098 - Zinc knuckle
PF03828 - Cid1 family poly A polymerase
PF14392 - Zinc knuckle
PF16631 - Unstructured region 4 on terminal uridylyltransferase 7
PF19088 - TUTase nucleotidyltransferase domain

SCOP Domains:
81631 - PAP/OAS1 substrate-binding domain
81301 - Nucleotidyltransferase
57667 - beta-beta-alpha zinc fingers
57756 - Retrovirus zinc finger-like domains

ModBase Predicted Comparative 3D Structure on Q5VYS8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0008270 zinc ion binding
GO:0016740 transferase activity
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
GO:0050265 RNA uridylyltransferase activity

Biological Process:
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0031123 RNA 3'-end processing
GO:0071044 histone mRNA catabolic process

Cellular Component:
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  LF209814 - JP 2014500723-A/17317: Polycomb-Associated Non-Coding RNAs.
AL832988 - Homo sapiens mRNA; cDNA DKFZp666E203 (from clone DKFZp666E203).
BC015897 - Homo sapiens zinc finger, CCHC domain containing 6, mRNA (cDNA clone IMAGE:3906857), partial cds.
AL832193 - Homo sapiens mRNA; cDNA DKFZp686C032 (from clone DKFZp686C032).
CR933644 - Homo sapiens mRNA; cDNA DKFZp686F119 (from clone DKFZp686F119).
AL832026 - Homo sapiens mRNA; cDNA DKFZp451K134 (from clone DKFZp451K134).
CR933643 - Homo sapiens mRNA; cDNA DKFZp686C11112 (from clone DKFZp686C11112).
AK058021 - Homo sapiens cDNA FLJ25292 fis, clone STM07318.
AK023471 - Homo sapiens cDNA FLJ13409 fis, clone PLACE1001716.
CR936608 - Homo sapiens mRNA; cDNA DKFZp686I1269 (from clone DKFZp686I1269).
JD497992 - Sequence 479016 from Patent EP1572962.
JD375044 - Sequence 356068 from Patent EP1572962.
JD170674 - Sequence 151698 from Patent EP1572962.
AB051498 - Homo sapiens mRNA for KIAA1711 protein, partial cds.
JD278214 - Sequence 259238 from Patent EP1572962.
BC144523 - Homo sapiens cDNA clone IMAGE:9053050.
JD496247 - Sequence 477271 from Patent EP1572962.
AL832965 - Homo sapiens mRNA; cDNA DKFZp666B142 (from clone DKFZp666B142).
BX641077 - Homo sapiens mRNA; cDNA DKFZp686E246 (from clone DKFZp686E246).
LF331844 - JP 2014500723-A/139347: Polycomb-Associated Non-Coding RNAs.
LF331845 - JP 2014500723-A/139348: Polycomb-Associated Non-Coding RNAs.
JD108161 - Sequence 89185 from Patent EP1572962.
JD250160 - Sequence 231184 from Patent EP1572962.
JD047347 - Sequence 28371 from Patent EP1572962.
AB527088 - Synthetic construct DNA, clone: pF1KSDA1711, Homo sapiens ZCCHC6 gene for zinc finger, CCHC domain containing 6, without stop codon, in Flexi system.
AB587345 - Synthetic construct DNA, clone: pF1KE1080, Homo sapiens ZCCHC6 gene for zinc finger, CCHC domain containing 6, without stop codon, in Flexi system.
AM393021 - Synthetic construct Homo sapiens clone IMAGE:100002464 for hypothetical protein (ZCCHC6 gene).
AM393523 - Synthetic construct Homo sapiens clone IMAGE:100002359 for hypothetical protein (ZCCHC6 gene).
LF331846 - JP 2014500723-A/139349: Polycomb-Associated Non-Coding RNAs.
AK055948 - Homo sapiens cDNA FLJ31386 fis, clone NT2NE1000014, weakly similar to Schizosaccharomyces pombe caffeine-induced death protein 1 (cid1) mRNA.
AK055546 - Homo sapiens cDNA FLJ30984 fis, clone HHDPC2000456.
BC111003 - Homo sapiens cDNA clone IMAGE:5745808, containing frame-shift errors.
BC032456 - Homo sapiens zinc finger, CCHC domain containing 6, mRNA (cDNA clone IMAGE:5172299), complete cds.
BC016387 - Homo sapiens zinc finger, CCHC domain containing 6, mRNA (cDNA clone IMAGE:4721899), partial cds.
AK308352 - Homo sapiens cDNA, FLJ98300.
MA567421 - JP 2018138019-A/139347: Polycomb-Associated Non-Coding RNAs.
MA567422 - JP 2018138019-A/139348: Polycomb-Associated Non-Coding RNAs.
MA567423 - JP 2018138019-A/139349: Polycomb-Associated Non-Coding RNAs.
MA445391 - JP 2018138019-A/17317: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q5VYS8 (Reactome details) participates in the following event(s):

R-HSA-8941312 ZCCHC6, ZCCHC11 are mRNA uridyltransferases
R-HSA-429947 Deadenylation of mRNA
R-HSA-429914 Deadenylation-dependent mRNA decay
R-HSA-8953854 Metabolism of RNA

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000375960.1, ENST00000375960.2, ENST00000375960.3, ENST00000375960.4, ENST00000375960.5, HS2, KIAA1711, NM_001185074, Q5H9T0, Q5VYS5, Q5VYS7, Q5VYS8, Q658Z9, Q659A2, Q6MZJ3, Q8N5F0, Q96N57, Q96NE8, Q9C0F2, Q9H8M6, TUT7 , TUT7_HUMAN, uc318mqe.1, uc318mqe.2, ZCCHC6
UCSC ID: ENST00000375960.6_5
RefSeq Accession: NM_001185074.2
Protein: Q5VYS8 (aka TUT7_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.