ID:ZGPAT_HUMAN DESCRIPTION: RecName: Full=Zinc finger CCCH-type with G patch domain-containing protein; AltName: Full=G patch domain-containing protein 6; AltName: Full=Zinc finger CCCH domain-containing protein 9; AltName: Full=Zinc finger and G patch domain-containing protein; FUNCTION: Transcription repressor that specifically binds the 5'- GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. SUBUNIT: Interacts with CHD4/Mi-2; the interaction is direct. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Widely expressed. INDUCTION: Down-regulated in breast carcinomas. SIMILARITY: Contains 1 C3H1-type zinc finger. SIMILARITY: Contains 1 G-patch domain. SEQUENCE CAUTION: Sequence=BAB47476.3; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAC11317.1; Type=Frameshift; Positions=290; Sequence=CAI95713.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8N5A5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0043565 sequence-specific DNA binding GO:0046872 metal ion binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0007175 negative regulation of epidermal growth factor-activated receptor activity GO:0045892 negative regulation of transcription, DNA-templated
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
