Human Gene ZKSCAN7 (ENST00000273320.7_1) from GENCODE V47lift37
  Description: zinc finger with KRAB and SCAN domains 7, transcript variant 1 (from RefSeq NM_018651.4)
Gencode Transcript: ENST00000273320.7_1
Gencode Gene: ENSG00000196345.13_12
Transcript (Including UTRs)
   Position: hg19 chr3:44,596,700-44,613,650 Size: 16,951 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr3:44,598,540-44,612,867 Size: 14,328 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:44,596,700-44,613,650)mRNA (may differ from genome)Protein (754 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIPubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZN167_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 167; AltName: Full=Zinc finger protein 448; AltName: Full=Zinc finger protein 64; AltName: Full=Zinc finger protein with KRAB and SCAN domains 7;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Potential).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 13 C2H2-type zinc fingers.
SIMILARITY: Contains 1 KRAB domain.
SIMILARITY: Contains 1 SCAN box domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.77 RPKM in Pituitary
Total median expression: 70.92 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -165.50429-0.386 Picture PostScript Text
3' UTR -157.60783-0.201 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR008916 - Retrov_capsid_C
IPR003309 - Tscrpt_reg_SCAN
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF01352 - KRAB box
PF02023 - SCAN domain
PF13912 - C2H2-type zinc finger

SCOP Domains:
109640 - KRAB domain (Kruppel-associated box)
47353 - Retrovirus capsid dimerization domain-like
57667 - beta-beta-alpha zinc fingers
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57783 - Zinc beta-ribbon
57802 - Rubredoxin-like
57889 - Cysteine-rich domain
161219 - CHY zinc finger-like

ModBase Predicted Comparative 3D Structure on Q9P0L1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  LF208680 - JP 2014500723-A/16183: Polycomb-Associated Non-Coding RNAs.
AK291285 - Homo sapiens cDNA FLJ78062 complete cds, highly similar to Homo sapiens zinc finger protein 167 (ZNF167), transcript variant 1, mRNA.
AY280798 - Homo sapiens zinc finger protein 448 (ZNF448) mRNA, complete cds.
BC063020 - Homo sapiens zinc finger protein 167, mRNA (cDNA clone IMAGE:5243862), complete cds.
AK022800 - Homo sapiens cDNA FLJ12738 fis, clone NT2RP2000420, moderately similar to ZINC FINGER PROTEIN 165.
BC010555 - Homo sapiens zinc finger protein 167, mRNA (cDNA clone IMAGE:4154814), complete cds.
DQ577942 - Homo sapiens piRNA piR-46054, complete sequence.
BC120983 - Homo sapiens zinc finger protein 167, mRNA (cDNA clone IMAGE:40116066), complete cds.
BC127639 - Homo sapiens zinc finger protein 167, mRNA (cDNA clone IMAGE:40116057), complete cds.
BC127640 - Homo sapiens zinc finger protein 167, mRNA (cDNA clone IMAGE:40116058), complete cds.
BC148260 - Homo sapiens zinc finger protein 167, mRNA (cDNA clone IMAGE:40116067), partial cds.
BC120982 - Homo sapiens zinc finger protein 167, mRNA (cDNA clone IMAGE:40116065), complete cds.
AF154846 - Homo sapiens zinc finger protein (ZFP) mRNA, complete cds.
AF075093 - Homo sapiens full length insert cDNA YQ86E07.
JD262976 - Sequence 244000 from Patent EP1572962.
BC166704 - Synthetic construct Homo sapiens clone IMAGE:100066430, MGC:195567 zinc finger protein 167 (ZNF167) mRNA, encodes complete protein.
LF378945 - JP 2014500723-A/186448: Polycomb-Associated Non-Coding RNAs.
DQ596679 - Homo sapiens piRNA piR-34745, complete sequence.
DQ570995 - Homo sapiens piRNA piR-31107, complete sequence.
LF378946 - JP 2014500723-A/186449: Polycomb-Associated Non-Coding RNAs.
LF378947 - JP 2014500723-A/186450: Polycomb-Associated Non-Coding RNAs.
L32164 - Homo sapiens zinc finger protein mRNA, 3' end.
JD314875 - Sequence 295899 from Patent EP1572962.
JD374099 - Sequence 355123 from Patent EP1572962.
JD419125 - Sequence 400149 from Patent EP1572962.
JD492234 - Sequence 473258 from Patent EP1572962.
JD345778 - Sequence 326802 from Patent EP1572962.
JD042242 - Sequence 23266 from Patent EP1572962.
JD103426 - Sequence 84450 from Patent EP1572962.
JD289796 - Sequence 270820 from Patent EP1572962.
JD095803 - Sequence 76827 from Patent EP1572962.
MA444257 - JP 2018138019-A/16183: Polycomb-Associated Non-Coding RNAs.
MA614522 - JP 2018138019-A/186448: Polycomb-Associated Non-Coding RNAs.
MA614523 - JP 2018138019-A/186449: Polycomb-Associated Non-Coding RNAs.
MA614524 - JP 2018138019-A/186450: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9P0L1 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: A0PJV3, A8K5H0, ENST00000273320.1, ENST00000273320.2, ENST00000273320.3, ENST00000273320.4, ENST00000273320.5, ENST00000273320.6, NM_018651, Q6WL09, Q96FQ2, Q9P0L1, uc317jbo.1, ZKSC7_HUMAN, ZNF167, ZNF448, ZNF64
UCSC ID: ENST00000273320.7_1
RefSeq Accession: NM_018651.4
Protein: Q9P0L1 (aka ZN167_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.