Human Gene ZNF197 (ENST00000344387.9_5) from GENCODE V47lift37

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Description: zinc finger protein 197, transcript variant 1 (from RefSeq NM_006991.5)
Gencode Transcript: ENST00000344387.9_5
Gencode Gene: ENSG00000186448.15_13
Transcript (Including UTRs)
Position: hg19 chr3:44,666,528-44,689,963 Size: 23,436 Total Exon Count: 6 Strand: +
Coding Region
Position: hg19 chr3:44,670,647-44,685,712 Size: 15,066 Coding Exon Count: 5

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr3:44,666,528-44,689,963)			mRNA (may differ from genome)		Protein (1029 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
Human Cortex Gene Expression	MGI	OMIM	PubMed	Reactome	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: ZN197_HUMAN DESCRIPTION: RecName: Full=Zinc finger protein 197; AltName: Full=Zinc finger protein with KRAB and SCAN domains 9; AltName: Full=ZnF20; AltName: Full=pVHL-associated KRAB domain-containing protein; FUNCTION: May be involved in transcriptional regulation. SUBCELLULAR LOCATION: Nucleus (Probable). SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family. SIMILARITY: Contains 22 C2H2-type zinc fingers. SIMILARITY: Contains 1 KRAB domain. SIMILARITY: Contains 1 SCAN box domain.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D000638 Amiodarone D016572 Cyclosporine D013749 Tetrachlorodibenzodioxin C006780 bisphenol A C029892 cupric chloride

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 4.49 RPKM in Brain - Cerebellar Hemisphere Total median expression: 139.55 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-63.20	189	-0.334	Picture	PostScript	Text
3' UTR	-1082.70	4251	-0.255	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR008916 - Retrov_capsid_C
IPR003309 - Tscrpt_reg_SCAN
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF01352 - KRAB box
PF02023 - SCAN domain
PF13912 - C2H2-type zinc finger

SCOP Domains:
48695 - Multiheme cytochromes
109640 - KRAB domain (Kruppel-associated box)
47353 - Retrovirus capsid dimerization domain-like
57667 - beta-beta-alpha zinc fingers
57783 - Zinc beta-ribbon
57802 - Rubredoxin-like
57889 - Cysteine-rich domain

ModBase Predicted Comparative 3D Structure on O14709


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0046872 metal ion binding Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter Cellular Component: GO:0005622 intracellular GO:0005634 nucleus

Descriptions from all associated GenBank mRNAs


	JD412660 - Sequence 393684 from Patent EP1572962. JD512596 - Sequence 493620 from Patent EP1572962. AY279353 - Homo sapiens truncated zinc finger protein 197 (ZNF197) mRNA, complete cds. AK314196 - Homo sapiens cDNA, FLJ94922, Homo sapiens zinc finger protein 197 (ZNF197), mRNA. AY074878 - Homo sapiens pVHL-associated KRAB domain-containing protein (VHLAK) mRNA, complete cds. BC031209 - Homo sapiens zinc finger protein 197, mRNA (cDNA clone IMAGE:5263701), containing frame-shift errors. BC017584 - Homo sapiens zinc finger protein 197, mRNA (cDNA clone IMAGE:4828392), partial cds. AY261677 - Homo sapiens Znf197 truncated protein mRNA, partial cds. AF011573 - Homo sapiens zinc finger protein mRNA, complete cds. AB587322 - Synthetic construct DNA, clone: pF1KB3654, Homo sapiens ZNF197 gene for zinc finger protein 197, without stop codon, in Flexi system. BC167827 - Synthetic construct Homo sapiens clone IMAGE:100068217, MGC:195834 zinc finger protein 197 (ZNF197) mRNA, encodes complete protein. Z21707 - H.sapiens p18 mRNA. L32163 - Homo sapiens zinc finger protein mRNA, 3' end. JD047452 - Sequence 28476 from Patent EP1572962. JD244535 - Sequence 225559 from Patent EP1572962. JD395848 - Sequence 376872 from Patent EP1572962. JD179676 - Sequence 160700 from Patent EP1572962. JD179677 - Sequence 160701 from Patent EP1572962. JD127486 - Sequence 108510 from Patent EP1572962. JD421965 - Sequence 402989 from Patent EP1572962. JD111963 - Sequence 92987 from Patent EP1572962. JD050319 - Sequence 31343 from Patent EP1572962. JD147514 - Sequence 128538 from Patent EP1572962. JD472302 - Sequence 453326 from Patent EP1572962. JD420775 - Sequence 401799 from Patent EP1572962. JD441150 - Sequence 422174 from Patent EP1572962. JD441151 - Sequence 422175 from Patent EP1572962. JD066481 - Sequence 47505 from Patent EP1572962. JD430499 - Sequence 411523 from Patent EP1572962. JD557550 - Sequence 538574 from Patent EP1572962. JD529750 - Sequence 510774 from Patent EP1572962. JD434978 - Sequence 416002 from Patent EP1572962. JD434979 - Sequence 416003 from Patent EP1572962. JD307147 - Sequence 288171 from Patent EP1572962. JD323026 - Sequence 304050 from Patent EP1572962. JD401760 - Sequence 382784 from Patent EP1572962. JD425129 - Sequence 406153 from Patent EP1572962. JD447049 - Sequence 428073 from Patent EP1572962. JD292797 - Sequence 273821 from Patent EP1572962. JD442659 - Sequence 423683 from Patent EP1572962. JD302447 - Sequence 283471 from Patent EP1572962. JD366984 - Sequence 348008 from Patent EP1572962. JD481451 - Sequence 462475 from Patent EP1572962. JD481452 - Sequence 462476 from Patent EP1572962. JD139150 - Sequence 120174 from Patent EP1572962. JD343985 - Sequence 325009 from Patent EP1572962. JD498107 - Sequence 479131 from Patent EP1572962. JD276794 - Sequence 257818 from Patent EP1572962. JD214504 - Sequence 195528 from Patent EP1572962. JD402987 - Sequence 384011 from Patent EP1572962. JD430998 - Sequence 412022 from Patent EP1572962. JD284145 - Sequence 265169 from Patent EP1572962. JD565370 - Sequence 546394 from Patent EP1572962. JD539471 - Sequence 520495 from Patent EP1572962. AL117657 - Homo sapiens mRNA; cDNA DKFZp586F1924 (from clone DKFZp586F1924).

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein O14709 (Reactome details) participates in the following event(s): R-HSA-975040 KRAB-ZNF / KAP Interaction R-HSA-212436 Generic Transcription Pathway R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription)

Other Names for This Gene


	Alternate Gene Symbols: B2RAH8, ENST00000344387.1, ENST00000344387.2, ENST00000344387.3, ENST00000344387.4, ENST00000344387.5, ENST00000344387.6, ENST00000344387.7, ENST00000344387.8, NM_006991, O14709, Q86VG0, uc317wxw.1, uc317wxw.2, ZKSCAN9, ZN197_HUMAN, ZNF166 UCSC ID: ENST00000344387.9_5 RefSeq Accession: NM_006991.5 Protein: O14709 (aka ZN197_HUMAN or Z197_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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