Human Gene ZNF212 (ENST00000335870.7_4) from GENCODE V47lift37
  Description: zinc finger protein 212 (from RefSeq NM_012256.4)
Gencode Transcript: ENST00000335870.7_4
Gencode Gene: ENSG00000170260.9_9
Transcript (Including UTRs)
   Position: hg19 chr7:148,936,742-148,952,697 Size: 15,956 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr7:148,936,870-148,951,506 Size: 14,637 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:148,936,742-148,952,697)mRNA (may differ from genome)Protein (495 aa)
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BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZN212_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 212; AltName: Full=Zinc finger protein C2H2-150;
FUNCTION: May be involved in transcriptional regulation.
INTERACTION: Self; NbExp=2; IntAct=EBI-1640204, EBI-1640204; P17036:ZNF3; NbExp=4; IntAct=EBI-1640204, EBI-1640965;
SUBCELLULAR LOCATION: Nucleus (Potential).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 4 C2H2-type zinc fingers.
SIMILARITY: Contains 1 KRAB domain.
SEQUENCE CAUTION: Sequence=AAC51296.1; Type=Erroneous initiation; Sequence=AAD45826.2; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.04 RPKM in Testis
Total median expression: 258.27 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -51.70128-0.404 Picture PostScript Text
3' UTR -418.201191-0.351 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR022137 - DUF3669_Znf
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF01352 - KRAB box
PF12874 - Zinc-finger of C2H2 type
PF13912 - C2H2-type zinc finger
PF13913 - zinc-finger of a C2HC-type

SCOP Domains:
109640 - KRAB domain (Kruppel-associated box)
57667 - beta-beta-alpha zinc fingers
57997 - Tropomyosin

ModBase Predicted Comparative 3D Structure on Q9UDV6
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AK074821 - Homo sapiens cDNA FLJ90340 fis, clone NT2RP2002564, highly similar to Zinc finger protein 212.
AK315086 - Homo sapiens cDNA, FLJ96042, Homo sapiens zinc finger protein 212 (ZNF212), mRNA.
BC022785 - Homo sapiens zinc finger protein 212, mRNA (cDNA clone MGC:9707 IMAGE:3849803), complete cds.
JD426244 - Sequence 407268 from Patent EP1572962.
JD409014 - Sequence 390038 from Patent EP1572962.
EU446738 - Synthetic construct Homo sapiens clone IMAGE:100070221; IMAGE:100011947; FLH258738.01L zinc finger protein 212 (ZNF212) gene, encodes complete protein.
KJ892458 - Synthetic construct Homo sapiens clone ccsbBroadEn_01852 ZNF212 gene, encodes complete protein.
CU692712 - Synthetic construct Homo sapiens gateway clone IMAGE:100019668 5' read ZNF212 mRNA.
LF207121 - JP 2014500723-A/14624: Polycomb-Associated Non-Coding RNAs.
LF362182 - JP 2014500723-A/169685: Polycomb-Associated Non-Coding RNAs.
U38864 - Human zinc-finger protein C2H2-150 mRNA, complete cds.
LF362183 - JP 2014500723-A/169686: Polycomb-Associated Non-Coding RNAs.
DQ580043 - Homo sapiens piRNA piR-48155, complete sequence.
DQ581468 - Homo sapiens piRNA piR-49580, complete sequence.
DQ590145 - Homo sapiens piRNA piR-57257, complete sequence.
JD156444 - Sequence 137468 from Patent EP1572962.
JD254899 - Sequence 235923 from Patent EP1572962.
JD456385 - Sequence 437409 from Patent EP1572962.
JD480646 - Sequence 461670 from Patent EP1572962.
JD136800 - Sequence 117824 from Patent EP1572962.
JD493399 - Sequence 474423 from Patent EP1572962.
JD563882 - Sequence 544906 from Patent EP1572962.
JD078795 - Sequence 59819 from Patent EP1572962.
JD527365 - Sequence 508389 from Patent EP1572962.
JD177066 - Sequence 158090 from Patent EP1572962.
JD284263 - Sequence 265287 from Patent EP1572962.
JD503104 - Sequence 484128 from Patent EP1572962.
JD235095 - Sequence 216119 from Patent EP1572962.
JD470276 - Sequence 451300 from Patent EP1572962.
JD559394 - Sequence 540418 from Patent EP1572962.
JD525875 - Sequence 506899 from Patent EP1572962.
JD105102 - Sequence 86126 from Patent EP1572962.
JD036577 - Sequence 17601 from Patent EP1572962.
JD276576 - Sequence 257600 from Patent EP1572962.
MA442698 - JP 2018138019-A/14624: Polycomb-Associated Non-Coding RNAs.
MA597759 - JP 2018138019-A/169685: Polycomb-Associated Non-Coding RNAs.
MA597760 - JP 2018138019-A/169686: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9UDV6 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: B2RCF4, ENST00000335870.1, ENST00000335870.2, ENST00000335870.3, ENST00000335870.4, ENST00000335870.5, ENST00000335870.6, NM_012256, Q13396, Q8N664, Q9UDV6, uc317ujt.1, uc317ujt.2, ZN212_HUMAN, ZNFC150
UCSC ID: ENST00000335870.7_4
RefSeq Accession: NM_012256.4
Protein: Q9UDV6 (aka ZN212_HUMAN or Z212_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.