Human Gene ZNF426 (ENST00000253115.7_11) from GENCODE V47lift37

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Description: zinc finger protein 426, transcript variant 1 (from RefSeq NM_024106.3)
Gencode Transcript: ENST00000253115.7_11
Gencode Gene: ENSG00000130818.12_13
Transcript (Including UTRs)
Position: hg19 chr19:9,633,899-9,649,321 Size: 15,423 Total Exon Count: 8 Strand: -
Coding Region
Position: hg19 chr19:9,639,056-9,646,908 Size: 7,853 Coding Exon Count: 6

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr19:9,633,899-9,649,321)			mRNA (may differ from genome)		Protein (554 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	PubMed	Reactome	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: ZN426_HUMAN DESCRIPTION: RecName: Full=Zinc finger protein 426; FUNCTION: May be involved in transcriptional regulation. SUBCELLULAR LOCATION: Nucleus (Potential). SIMILARITY: Contains 12 C2H2-type zinc fingers. SIMILARITY: Contains 1 KRAB domain.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: ZNF426 Diseases sorted by gene-association score: kaposi sarcoma (11)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D019327 Copper Sulfate D004958 Estradiol D011374 Progesterone

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 5.39 RPKM in Esophagus - Mucosa Total median expression: 81.94 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-90.70	282	-0.322	Picture	PostScript	Text
3' UTR	-2020.10	5157	-0.392	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF01352 - KRAB box
PF12874 - Zinc-finger of C2H2 type
PF13894 - C2H2-type zinc finger
PF13912 - C2H2-type zinc finger
PF13913 - zinc-finger of a C2HC-type

SCOP Domains:
48695 - Multiheme cytochromes
109640 - KRAB domain (Kruppel-associated box)
57667 - beta-beta-alpha zinc fingers
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57783 - Zinc beta-ribbon
57802 - Rubredoxin-like

ModBase Predicted Comparative 3D Structure on Q9BUY5


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0005515 protein binding GO:0046872 metal ion binding Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter Cellular Component: GO:0005622 intracellular GO:0005634 nucleus

Descriptions from all associated GenBank mRNAs


	AK024250 - Homo sapiens cDNA FLJ14188 fis, clone NT2RP2005980. JD027652 - Sequence 8676 from Patent EP1572962. JD254732 - Sequence 235756 from Patent EP1572962. JD308161 - Sequence 289185 from Patent EP1572962. JD280728 - Sequence 261752 from Patent EP1572962. JD509603 - Sequence 490627 from Patent EP1572962. BC001791 - Homo sapiens zinc finger protein 426, mRNA (cDNA clone MGC:2663 IMAGE:3543910), complete cds. AK095759 - Homo sapiens cDNA FLJ38440 fis, clone FEBRA2017138, highly similar to Zinc finger protein 426. AB209837 - Homo sapiens mRNA for zinc finger protein 426 variant protein. JD217385 - Sequence 198409 from Patent EP1572962. JD366563 - Sequence 347587 from Patent EP1572962. JD534843 - Sequence 515867 from Patent EP1572962. JD059738 - Sequence 40762 from Patent EP1572962. JD517738 - Sequence 498762 from Patent EP1572962. JD149425 - Sequence 130449 from Patent EP1572962. JD269608 - Sequence 250632 from Patent EP1572962. JD354035 - Sequence 335059 from Patent EP1572962. JD294098 - Sequence 275122 from Patent EP1572962. JD327207 - Sequence 308231 from Patent EP1572962. JD145386 - Sequence 126410 from Patent EP1572962. JD197163 - Sequence 178187 from Patent EP1572962. JD366057 - Sequence 347081 from Patent EP1572962. JD116029 - Sequence 97053 from Patent EP1572962. JD558236 - Sequence 539260 from Patent EP1572962. JD082328 - Sequence 63352 from Patent EP1572962. JD502612 - Sequence 483636 from Patent EP1572962. JD516786 - Sequence 497810 from Patent EP1572962. JD554025 - Sequence 535049 from Patent EP1572962. JD151643 - Sequence 132667 from Patent EP1572962. JD522236 - Sequence 503260 from Patent EP1572962. JD556282 - Sequence 537306 from Patent EP1572962. JD558235 - Sequence 539259 from Patent EP1572962. JD564286 - Sequence 545310 from Patent EP1572962. JD078561 - Sequence 59585 from Patent EP1572962. JD504005 - Sequence 485029 from Patent EP1572962. JD429075 - Sequence 410099 from Patent EP1572962. JD061470 - Sequence 42494 from Patent EP1572962. JD506453 - Sequence 487477 from Patent EP1572962. JD284118 - Sequence 265142 from Patent EP1572962. JD202922 - Sequence 183946 from Patent EP1572962. DQ892524 - Synthetic construct clone IMAGE:100005154; FLH187161.01X; RZPDo839E0572D zinc finger protein 426 (ZNF426) gene, encodes complete protein. KJ894652 - Synthetic construct Homo sapiens clone ccsbBroadEn_04046 ZNF426 gene, encodes complete protein. DQ895736 - Synthetic construct Homo sapiens clone IMAGE:100010196; FLH187157.01L; RZPDo839E0562D zinc finger protein 426 (ZNF426) gene, encodes complete protein. AB528500 - Synthetic construct DNA, clone: pF1KB7863, Homo sapiens ZNF426 gene for zinc finger protein 426, without stop codon, in Flexi system. JD032199 - Sequence 13223 from Patent EP1572962. JD032199 - Sequence 13223 from Patent EP1572962. JD480740 - Sequence 461764 from Patent EP1572962. JD362922 - Sequence 343946 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q9BUY5 (Reactome details) participates in the following event(s): R-HSA-975040 KRAB-ZNF / KAP Interaction R-HSA-212436 Generic Transcription Pathway R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription)

Other Names for This Gene


	Alternate Gene Symbols: B3KTL2, ENST00000253115.1, ENST00000253115.2, ENST00000253115.3, ENST00000253115.4, ENST00000253115.5, ENST00000253115.6, NM_024106, Q9BUY5, uc317fkh.1, uc317fkh.2, ZN426_HUMAN UCSC ID: ENST00000253115.7_11 RefSeq Accession: NM_024106.3 Protein: Q9BUY5 (aka ZN426_HUMAN or Z426_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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