Human Gene ZNF487 (ENST00000315429.12_8) from GENCODE V47lift37
  Description: zinc finger protein 487, transcript variant 5 (from RefSeq NM_001355448.2)
Gencode Transcript: ENST00000315429.12_8
Gencode Gene: ENSG00000243660.12_15
Transcript (Including UTRs)
   Position: hg19 chr10:43,932,289-43,978,629 Size: 46,341 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr10:43,971,259-43,977,370 Size: 6,112 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:43,932,289-43,978,629)mRNA (may differ from genome)Protein (208 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: H0Y2R6_HUMAN
DESCRIPTION: SubName: Full=Putative zinc finger protein 487; Flags: Fragment;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 10.39 RPKM in Testis
Total median expression: 56.19 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -73.80185-0.399 Picture PostScript Text
3' UTR -293.601259-0.233 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box

SCOP Domains:
109640 - KRAB domain (Kruppel-associated box)
57667 - beta-beta-alpha zinc fingers

ModBase Predicted Comparative 3D Structure on H0Y2R6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding

Biological Process:
GO:0006355 regulation of transcription, DNA-templated

Cellular Component:
GO:0005622 intracellular


-  Descriptions from all associated GenBank mRNAs
  AK302442 - Homo sapiens cDNA FLJ52643 complete cds, weakly similar to Zinc finger protein 11B.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000315429.1, ENST00000315429.10, ENST00000315429.11, ENST00000315429.2, ENST00000315429.3, ENST00000315429.4, ENST00000315429.5, ENST00000315429.6, ENST00000315429.7, ENST00000315429.8, ENST00000315429.9, H0Y2R6, H0Y2R6_HUMAN, NM_001355448, uc317pus.1, uc317pus.2, ZNF487
UCSC ID: ENST00000315429.12_8
RefSeq Accession: NM_001355445.3
Protein: H0Y2R6

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.