Human Gene ZNF585A (ENST00000292841.10_7) from GENCODE V47lift37

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Description: zinc finger protein 585A, transcript variant 3 (from RefSeq NM_001288800.2)
Gencode Transcript: ENST00000292841.10_7
Gencode Gene: ENSG00000196967.11_9
Transcript (Including UTRs)
Position: hg19 chr19:37,636,442-37,663,597 Size: 27,156 Total Exon Count: 5 Strand: -
Coding Region
Position: hg19 chr19:37,642,491-37,660,812 Size: 18,322 Coding Exon Count: 4

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions
Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr19:37,636,442-37,663,597)			mRNA (may differ from genome)		Protein (769 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
MGI	PubMed	Reactome	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: Z585A_HUMAN DESCRIPTION: RecName: Full=Zinc finger protein 585A; FUNCTION: May be involved in transcriptional regulation. SUBCELLULAR LOCATION: Nucleus (Potential). SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family. SIMILARITY: Contains 22 C2H2-type zinc fingers. SIMILARITY: Contains 1 KRAB domain. SEQUENCE CAUTION: Sequence=BAB85057.1; Type=Erroneous initiation;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C044887 beta-methylcholine C024746 tobacco tar

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 3.22 RPKM in Brain - Cerebellar Hemisphere Total median expression: 70.30 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-67.40	213	-0.316	Picture	PostScript	Text
3' UTR	-1552.20	6049	-0.257	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF01352 - KRAB box
PF12874 - Zinc-finger of C2H2 type
PF13912 - C2H2-type zinc finger

SCOP Domains:
109640 - KRAB domain (Kruppel-associated box)
54171 - DNA-binding domain
56194 - Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain
57667 - beta-beta-alpha zinc fingers
57716 - Glucocorticoid receptor-like (DNA-binding domain)
82919 - Zn-finger domain of Sec23/24
57783 - Zinc beta-ribbon
57802 - Rubredoxin-like
63393 - RNA polymerase subunits
57889 - Cysteine-rich domain
57903 - FYVE/PHD zinc finger
161219 - CHY zinc finger-like

ModBase Predicted Comparative 3D Structure on Q6P3V2


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details
Gene Sorter

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003676 nucleic acid binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0046872 metal ion binding Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter Cellular Component: GO:0005622 intracellular GO:0005634 nucleus

Descriptions from all associated GenBank mRNAs


	KJ903985 - Synthetic construct Homo sapiens clone ccsbBroadEn_13379 ZNF585A gene, encodes complete protein. BC026081 - Homo sapiens zinc finger protein 585A, mRNA (cDNA clone IMAGE:4837344). JD360895 - Sequence 341919 from Patent EP1572962. JD379466 - Sequence 360490 from Patent EP1572962. JD148666 - Sequence 129690 from Patent EP1572962. AK123296 - Homo sapiens cDNA FLJ41302 fis, clone BRAMY2042122. AK074345 - Homo sapiens cDNA FLJ23765 fis, clone HEP19162. BC063820 - Homo sapiens zinc finger protein 585A, mRNA (cDNA clone MGC:74558 IMAGE:6500797), complete cds. JD547233 - Sequence 528257 from Patent EP1572962. AK056389 - Homo sapiens cDNA FLJ31827 fis, clone NT2RP6000100, moderately similar to ZINC FINGER PROTEIN 41. JD443670 - Sequence 424694 from Patent EP1572962. JD098230 - Sequence 79254 from Patent EP1572962. JD410588 - Sequence 391612 from Patent EP1572962. JD504513 - Sequence 485537 from Patent EP1572962. JD299367 - Sequence 280391 from Patent EP1572962. JD429902 - Sequence 410926 from Patent EP1572962. JD122500 - Sequence 103524 from Patent EP1572962. JD396926 - Sequence 377950 from Patent EP1572962. JD513858 - Sequence 494882 from Patent EP1572962. JD113172 - Sequence 94196 from Patent EP1572962. BC052956 - Homo sapiens zinc finger protein 585A, mRNA (cDNA clone IMAGE:4829279). BC039557 - Homo sapiens zinc finger protein 585A, mRNA (cDNA clone IMAGE:4498347), partial cds. JD132070 - Sequence 113094 from Patent EP1572962. JD250914 - Sequence 231938 from Patent EP1572962. AK290660 - Homo sapiens cDNA FLJ75189 complete cds, highly similar to Homo sapiens zinc finger protein 585A, mRNA. DQ581436 - Homo sapiens piRNA piR-49548, complete sequence. JD084043 - Sequence 65067 from Patent EP1572962. JD163901 - Sequence 144925 from Patent EP1572962. JD290911 - Sequence 271935 from Patent EP1572962. JD097364 - Sequence 78388 from Patent EP1572962. AB527690 - Synthetic construct DNA, clone: pF1KB6264, Homo sapiens ZNF585A gene for zinc finger protein 585A, without stop codon, in Flexi system. JD084020 - Sequence 65044 from Patent EP1572962. JD314878 - Sequence 295902 from Patent EP1572962. JD314877 - Sequence 295901 from Patent EP1572962. JD314879 - Sequence 295903 from Patent EP1572962. JD052106 - Sequence 33130 from Patent EP1572962. AF024705 - Homo sapiens clone L4-10 zinc finger protein mRNA, partial cds. JD314882 - Sequence 295906 from Patent EP1572962. JD507138 - Sequence 488162 from Patent EP1572962. JD314870 - Sequence 295894 from Patent EP1572962. JD314878 - Sequence 295902 from Patent EP1572962. JD314877 - Sequence 295901 from Patent EP1572962. JD314879 - Sequence 295903 from Patent EP1572962. JD434463 - Sequence 415487 from Patent EP1572962. JD314817 - Sequence 295841 from Patent EP1572962. JD314816 - Sequence 295840 from Patent EP1572962. JD314875 - Sequence 295899 from Patent EP1572962. JD314871 - Sequence 295895 from Patent EP1572962. AK098695 - Homo sapiens cDNA FLJ25829 fis, clone TST08126. AF086428 - Homo sapiens full length insert cDNA clone ZD79E05. JD235755 - Sequence 216779 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q6P3V2 (Reactome details) participates in the following event(s): R-HSA-975040 KRAB-ZNF / KAP Interaction R-HSA-212436 Generic Transcription Pathway R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription)

Other Names for This Gene


	Alternate Gene Symbols: ENST00000292841.1, ENST00000292841.2, ENST00000292841.3, ENST00000292841.4, ENST00000292841.5, ENST00000292841.6, ENST00000292841.7, ENST00000292841.8, ENST00000292841.9, NM_001288800, Q6P3V2, Q8TE95, Q96MV3, uc317lcn.1, uc317lcn.2, Z585A_HUMAN UCSC ID: ENST00000292841.10_7 RefSeq Accession: NM_001288800.2 Protein: Q6P3V2 (aka Z585A_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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