Human Gene ZNF672 (ENST00000306562.8_4) from GENCODE V47lift37
  Description: zinc finger protein 672 (from RefSeq NM_024836.3)
Gencode Transcript: ENST00000306562.8_4
Gencode Gene: ENSG00000171161.13_10
Transcript (Including UTRs)
   Position: hg19 chr1:249,132,423-249,143,716 Size: 11,294 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr1:249,141,474-249,142,832 Size: 1,359 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:249,132,423-249,143,716)mRNA (may differ from genome)Protein (452 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
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-  Comments and Description Text from UniProtKB
  ID: ZN672_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 672;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 14 C2H2-type zinc fingers.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 16.80 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 502.12 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -329.40802-0.411 Picture PostScript Text
3' UTR -301.70884-0.341 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF12874 - Zinc-finger of C2H2 type
PF13894 - C2H2-type zinc finger
PF13912 - C2H2-type zinc finger
PF13913 - zinc-finger of a C2HC-type

SCOP Domains:
57667 - beta-beta-alpha zinc fingers
57802 - Rubredoxin-like

ModBase Predicted Comparative 3D Structure on Q499Z4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm


-  Descriptions from all associated GenBank mRNAs
  BC029310 - Homo sapiens zinc finger protein 672, mRNA (cDNA clone IMAGE:5175166).
AK025954 - Homo sapiens cDNA: FLJ22301 fis, clone HRC04777.
AK298016 - Homo sapiens cDNA FLJ57544 complete cds, highly similar to Zinc finger protein 672.
JD173472 - Sequence 154496 from Patent EP1572962.
JD143761 - Sequence 124785 from Patent EP1572962.
JD140442 - Sequence 121466 from Patent EP1572962.
JD128521 - Sequence 109545 from Patent EP1572962.
BC068506 - Homo sapiens zinc finger protein 672, mRNA (cDNA clone MGC:87260 IMAGE:4824147), complete cds.
BC008872 - Homo sapiens zinc finger protein 672, mRNA (cDNA clone IMAGE:4136336), complete cds.
JD427503 - Sequence 408527 from Patent EP1572962.
JD282978 - Sequence 264002 from Patent EP1572962.
JD382583 - Sequence 363607 from Patent EP1572962.
JD049552 - Sequence 30576 from Patent EP1572962.
JD178317 - Sequence 159341 from Patent EP1572962.
JD177882 - Sequence 158906 from Patent EP1572962.
JD387723 - Sequence 368747 from Patent EP1572962.
AK027679 - Homo sapiens cDNA FLJ14773 fis, clone NT2RP3004566, weakly similar to ZINC FINGER PROTEIN 84.
JD386971 - Sequence 367995 from Patent EP1572962.
BC035140 - Homo sapiens zinc finger protein 672, mRNA (cDNA clone MGC:43244 IMAGE:5264126), complete cds.
BC050348 - Homo sapiens zinc finger protein 672, mRNA (cDNA clone MGC:51164 IMAGE:5260682), complete cds.
JD400994 - Sequence 382018 from Patent EP1572962.
JD055788 - Sequence 36812 from Patent EP1572962.
JD329280 - Sequence 310304 from Patent EP1572962.
JD300785 - Sequence 281809 from Patent EP1572962.
JD106344 - Sequence 87368 from Patent EP1572962.
JD118444 - Sequence 99468 from Patent EP1572962.
JD548747 - Sequence 529771 from Patent EP1572962.
JD055365 - Sequence 36389 from Patent EP1572962.
KJ899584 - Synthetic construct Homo sapiens clone ccsbBroadEn_08978 ZNF672 gene, encodes complete protein.
AB464768 - Synthetic construct DNA, clone: pF1KB8832, Homo sapiens ZNF672 gene for zinc finger protein 672, without stop codon, in Flexi system.
KJ906324 - Synthetic construct Homo sapiens clone ccsbBroadEn_15994 ZNF672 gene, encodes complete protein.
AK027476 - Homo sapiens cDNA FLJ14570 fis, clone NT2RM4000531.
BC007385 - Homo sapiens zinc finger protein 672, mRNA (cDNA clone IMAGE:3677471), partial cds.
JD232540 - Sequence 213564 from Patent EP1572962.
JD470169 - Sequence 451193 from Patent EP1572962.
JD560431 - Sequence 541455 from Patent EP1572962.
JD232524 - Sequence 213548 from Patent EP1572962.
JD399860 - Sequence 380884 from Patent EP1572962.
JD195626 - Sequence 176650 from Patent EP1572962.
JD261530 - Sequence 242554 from Patent EP1572962.
JD556727 - Sequence 537751 from Patent EP1572962.
DQ592416 - Homo sapiens piRNA piR-59528, complete sequence.
JD386361 - Sequence 367385 from Patent EP1572962.
JD158566 - Sequence 139590 from Patent EP1572962.
JD275993 - Sequence 257017 from Patent EP1572962.
JD343846 - Sequence 324870 from Patent EP1572962.
JD477116 - Sequence 458140 from Patent EP1572962.
JD334875 - Sequence 315899 from Patent EP1572962.
JD455628 - Sequence 436652 from Patent EP1572962.
JD096760 - Sequence 77784 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000306562.1, ENST00000306562.2, ENST00000306562.3, ENST00000306562.4, ENST00000306562.5, ENST00000306562.6, ENST00000306562.7, NM_024836, Q499Z4, Q96H65, Q96IM3, Q9H6G5, uc317nwm.1, uc317nwm.2, ZN672_HUMAN, ZNF672
UCSC ID: ENST00000306562.8_4
RefSeq Accession: NM_024836.3
Protein: Q499Z4 (aka ZN672_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.