Gene interactions and pathways from curated databases and text-mining
Exp Mol Med 2000, PMID: 11048639

The mechanism of phospholipase C-gamma1 regulation.

Kim, M J; Kim, E; Ryu, S H; Suh, P G

Phospholipase C (PLC)1 hydrolyzes phosphatidylinositol 4,5-bisphosphate to generate the second messengers, inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 induces a transient increase in intracellular free Ca2+, while DAG directly activates protein kinase C. Upon stimulation of cells with growth factors, PLC-gamma1 is activated upon their association with and phosphorylation by receptor and non-receptor tyrosine kinases. In this review, we will focus on the activation mechanism and regulatory function of PLC-gamma1.

Diseases/Pathways annotated by Medline MESH: Second Messenger Systems
Document information provided by NCBI PubMed

Text Mining Data

Dashed line = No text mining data

Manually curated Databases

  • Reactome Reaction: CD3D → PLCG1 (reaction)
  • Reactome Reaction: PLCG1 → HLA-DRB3 (reaction)
  • Reactome Reaction: LAT → PLCG1 (direct_complex)
  • Reactome Reaction: HLA-DQA2 → LAT (reaction)
  • Reactome Reaction: GRAP2 → HLA-DRB4 (reaction)
  • Reactome Reaction: HLA-DPA1 → LCP2 (reaction)
  • Reactome Reaction: CD3G → LAT (reaction)
  • Reactome Reaction: BTK → PLCG1 (reaction)
  • Reactome Reaction: GRAP2 → HLA-DPA1 (reaction)
  • Reactome Reaction: HLA-DQA2 → LCP2 (reaction)
  • Reactome Reaction: GRAP2 → HLA-DQB1 (reaction)
  • Reactome Reaction: LCK → LCP2 (reaction)
  • Reactome Reaction: PLCG1 → TRAC (reaction)
  • Reactome Reaction: LAT → LAT (reaction)
  • Reactome Reaction: PLCG1 → ZAP70 (reaction)
  • Reactome Reaction: LCK → PLCG1 (reaction)
  • Reactome Reaction: LAT → TRBC1 (reaction)
  • Reactome Reaction: CD3E → GRAP2 (reaction)
  • Reactome Reaction: GRAP2 → LCP2 (reaction)
  • Reactome Reaction: CD247 → LAT (reaction)
  • Reactome Reaction: LAT → PLCG1 (reaction)
  • Reactome Reaction: LCP2 → LCP2 (reaction)
  • Reactome Reaction: HLA-DPA1 → PLCG1 (reaction)
  • Reactome Reaction: GRAP2 → PLCG2 (reaction)
  • Reactome Reaction: HLA-DPA1 → LAT (reaction)
  • Reactome Reaction: LAT → HLA-DRB3 (reaction)
  • Reactome Reaction: PLCG2 → LAT (reaction)
  • Reactome Reaction: HLA-DQB1 → LAT (reaction)
  • Reactome Reaction: HLA-DQA1 → LCP2 (reaction)
  • Reactome Reaction: PLCG1 → SHC1 (reaction)
  • Reactome Reaction: LCP2 → TRAC (reaction)
  • Reactome Reaction: CD4 → PLCG1 (reaction)
  • Reactome Reaction: CD247 → PLCG1 (reaction)
  • Reactome Reaction: GRB2 → PLCG1 (reaction)
  • Reactome Reaction: CD4 → LAT (reaction)
  • Reactome Reaction: HLA-DRB1 → LCP2 (reaction)
  • Reactome Reaction: GRAP2 → HLA-DRB3 (reaction)
  • Reactome Reaction: LCP2 → PLCG2 (reaction)
  • Reactome Reaction: GRAP2 → HLA-DQA2 (reaction)
  • Reactome Reaction: HLA-DRB4 → PLCG1 (reaction)
  • Reactome Reaction: CD4 → GRAP2 (reaction)
  • Reactome Reaction: LAT → TRBV12-3 (reaction)
  • Reactome Reaction: PLCG1 → SOS1 (reaction)
  • Reactome Reaction: PLCG1 → LAT (reaction)
  • Reactome Reaction: GRAP2 → LCK (reaction)
  • Reactome Reaction: HLA-DRB1 → PLCG1 (reaction)
  • Reactome Reaction: HLA-DRB1 → LAT (reaction)
  • Reactome Reaction: CD247 → GRAP2 (reaction)
  • Reactome Reaction: GRB2 → PLCG2 (reaction)
  • Reactome Reaction: BTK → PLCG2 (reaction)
  • Reactome Reaction: LCP2 → HLA-DRB5 (reaction)
  • Reactome Reaction: HLA-DPB1 → PLCG1 (reaction)
  • Reactome Reaction: ITK → LCP2 (reaction)
  • Reactome Reaction: HLA-DQB2 → LAT (reaction)
  • Reactome Reaction: HLA-DQB1 → PLCG1 (reaction)
  • Reactome Reaction: GRAP2 → LAT (reaction)
  • Reactome Reaction: GRAP2 → TRAC (reaction)
  • Reactome Reaction: HLA-DRB4 → LAT (reaction)
  • Reactome Reaction: HLA-DPB1 → LCP2 (reaction)
  • Reactome Reaction: HLA-DRA → LCP2 (reaction)
  • Reactome Reaction: GRAP2 → HLA-DRB5 (reaction)
  • Reactome Reaction: HLA-DPB1 → LAT (reaction)
  • Reactome Reaction: CD3E → LAT (reaction)
  • Reactome Reaction: CD3G → LCP2 (reaction)
  • Reactome Reaction: LCP2 → PLCG1 (indirect_complex)
  • Reactome Reaction: CD3E → LCP2 (reaction)
  • Reactome Reaction: LAT → HLA-DRB5 (reaction)
  • Reactome Reaction: LCP2 → PLCG1 (reaction)
  • Reactome Reaction: CD3G → PLCG1 (reaction)
  • Reactome Reaction: LAT → LCP2 (reaction)
  • Reactome Reaction: HLA-DRA → PLCG1 (reaction)
  • Reactome Reaction: CD3G → GRAP2 (reaction)
  • Reactome Reaction: PLCG2 → VAV3 (reaction)
  • Reactome Reaction: PLCG1 → TRBC1 (reaction)
  • Reactome Reaction: LAT → LCK (reaction)
  • Reactome Reaction: CD3D → LCP2 (reaction)
  • Reactome Reaction: PLCG2 → VAV2 (reaction)
  • Reactome Reaction: LAT → TRAC (reaction)
  • Reactome Reaction: HLA-DQB2 → LCP2 (reaction)
  • Reactome Reaction: LCP2 → TRBV12-3 (reaction)
  • Reactome Reaction: PLCG1 → TRBV12-3 (reaction)
  • Reactome Reaction: HLA-DQB1 → LCP2 (reaction)
  • Reactome Reaction: GRAP2 → HLA-DRA (reaction)
  • Reactome Reaction: PLCG1 → HLA-DRB5 (reaction)
  • Reactome Reaction: HLA-DQA1 → PLCG1 (reaction)
  • Reactome Reaction: HLA-DQA2 → PLCG1 (reaction)
  • Reactome Reaction: ITK → PLCG1 (reaction)
  • Reactome Reaction: GRAP2 → HLA-DRB1 (reaction)
  • Reactome Reaction: LAT → ZAP70 (reaction)
  • Reactome Reaction: GRAP2 → ITK (reaction)
  • Reactome Reaction: CD3E → PLCG1 (reaction)
  • Reactome Reaction: CD3D → GRAP2 (reaction)
  • Reactome Reaction: GRAP2 → HLA-DQA1 (reaction)
  • Reactome Reaction: GRAP2 → HLA-DPB1 (reaction)
  • Reactome Reaction: LAT → PLCG1 (indirect_complex)
  • Reactome Reaction: GRAP2 → PLCG1 (reaction)
  • Reactome Reaction: GRAP2 → GRAP2 (reaction)
  • Reactome Reaction: GRAP2 → PLCG1 (indirect_complex)
  • Reactome Reaction: HLA-DRA → LAT (reaction)
  • Reactome Reaction: HLA-DRB4 → LCP2 (reaction)
  • Reactome Reaction: GRAP2 → ZAP70 (reaction)
  • Reactome Reaction: PLCG2 → SOS1 (reaction)
  • Reactome Reaction: HLA-DQA1 → LAT (reaction)
  • Reactome Reaction: GRAP2 → HLA-DQB2 (reaction)
  • Reactome Reaction: HLA-DQB2 → PLCG1 (reaction)
  • Reactome Reaction: CD3D → LAT (reaction)
  • Reactome Reaction: PLCG1 → VAV3 (reaction)
  • Reactome Reaction: CD247 → LCP2 (reaction)
  • Reactome Reaction: GRAP2 → TRBV12-3 (reaction)
  • Reactome Reaction: PLCG1 → VAV2 (reaction)
  • Reactome Reaction: CD4 → LCP2 (reaction)
  • Reactome Reaction: LCP2 → ZAP70 (reaction)
  • Reactome Reaction: LCP2 → HLA-DRB3 (reaction)
  • Reactome Reaction: GRAP2 → TRBC1 (reaction)
  • Reactome Reaction: ITK → LAT (reaction)
  • Reactome Reaction: PLCG2 → SHC1 (reaction)
  • Reactome Reaction: LCP2 → TRBC1 (reaction)
In total, 112 gene pairs are associated to this article in curated databases