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Gene interactions and pathways from curated databases and text-mining

Genes Dev 2003, PMID: 12533515

Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation.

Habas, Raymond; Dawid, Igor B; He, Xi

Wnt/Frizzled (Fz) signaling controls cell polarity/movements during vertebrate gastrulation via incompletely defined mechanisms. We demonstrated previously that Wnt/Fz activation of Rho, a GTPase and regulator of cytoskeletal architecture, is essential for vertebrate gastrulation. Here we report that in mammalian cells and Xenopus embryos, Wnt/Fz signaling coactivates Rho and Rac, another GTPase and distinct regulator of cytoskeletal architecture. Wnt/Fz activation of Rac is independent of Rho and mediates Wnt/Fz activation of Jun N-terminal kinase (JNK). Dishevelled (Dvl), a cytoplasmic protein downstream of Fz, forms a Wnt-induced complex with Rac independent of the Wnt-induced Dvl-Rho complex. Depletion or inhibition of Rac function perturbs Xenopus gastrulation without affecting Wnt/Fz activation of the Rho or beta-catenin pathway. We propose that parallel activation of Rac and Rho pathways by Wnt/Fz signaling is required for cell polarity and movements during vertebrate gastrulation.

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Text Mining Data

Wnt/Fz → Rho: " We demonstrated previously that Wnt/Fz activation of Rho , a GTPase and regulator of cytoskeletal architecture, is essential for vertebrate gastrulation "

Wnt/Fz → Jun N-terminal kinase (JNK): " Wnt/Fz activation of Rac is independent of Rho and mediates Wnt/Fz activation of Jun N-terminal kinase (JNK) "

Wnt/Fz → Rac: " Wnt/Fz activation of Rac is independent of Rho and mediates Wnt/Fz activation of Jun N-terminal kinase (JNK) "

Jun N-terminal kinase (JNK) → Rac: " Wnt/Fz activation of Rac is independent of Rho and mediates Wnt/Fz activation of Jun N-terminal kinase (JNK) "

Dvl-Rho → Wnt: " Dishevelled ( Dvl ), a cytoplasmic protein downstream of Fz, forms a Wnt induced complex with Rac independent of the Wnt induced Dvl-Rho complex "

Rac → Wnt: " Dishevelled ( Dvl ), a cytoplasmic protein downstream of Fz, forms a Wnt induced complex with Rac independent of the Wnt induced Dvl-Rho complex "

Manually curated Databases

IRef Hprd Interaction: DVL2 — RHOA (in vivo)
IRef Hprd Interaction: DVL2 — RAC1 (in vivo)
IRef Hprd Interaction: RAC1 — DVL1 (in vivo)
Reactome Reaction: DVL2 → RAC1 (reaction)
Reactome Reaction: DVL2 → RAC1 (indirect_complex)

In total, 3 gene pairs are associated to this article in curated databases