Gene interactions and pathways from curated databases and text-mining
Immunity 2003, PMID: 14563325

Bam32 links the B cell receptor to ERK and JNK and mediates B cell proliferation but not survival.

Han, Arnold; Saijo, Kaoru; Mecklenbräuker, Ingrid; Tarakhovsky, Alexander; Nussenzweig, Michel C

Bam32 is an adaptor protein recruited to the plasma membrane upon B cell receptor (BCR) crosslinking in a phosphoinositol 3-kinase (PI3K)-dependent manner; however, its physiologic function is unclear. To determine its physiologic function, we produced Bam32-deficient mice. Bam32(-/-) B cells develop normally but have impaired T-independent antibody responses in vivo and diminished responses to BCR crosslinking in vitro. Biochemical analysis revealed that Bam32 acts in a novel pathway leading from the BCR to MAPK/ERK Kinases (MEK1/2), MAPK/ERK Kinase Kinase-1 (MEKK1), extracellular signal-regulated kinase (ERK), and c-jun NH2-terminal kinase (JNK), but not p38 mitogen-activated protein kinase (p38). This pathway appears to be initiated by hematopoietic progenitor kinase-1 (HPK1), which interacts directly with Bam32, and differs from all previously characterized BCR signaling pathways in that it is required for normal BCR-mediated proliferation but not for B cell survival.

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Text Mining Data

Dashed line = No text mining data

Manually curated Databases

  • IRef Hprd Interaction: MAP4K1 — DAPP1 (in vivo)
  • IRef Hprd Interaction: MAP4K1 — DAPP1 (in vitro)
  • NCI Pathway Database BCR signaling pathway: Bam32/HPK1 complex (DAPP1-MAP4K1) → Bam32 (DAPP1) (modification, collaborate)
    Evidence: assay, physical interaction
  • NCI Pathway Database BCR signaling pathway: Bam32/HPK1 complex (DAPP1-MAP4K1) → HPK1 (MAP4K1) (modification, collaborate)
    Evidence: assay, physical interaction
  • NCI Pathway Database BCR signaling pathway: Bam32 (DAPP1) → HPK1 (MAP4K1) (modification, collaborate)
    Evidence: assay, physical interaction
  • NCI Pathway Database BCR signaling pathway: RAC1 (RAC1) → TAK1 (MAP3K7) (modification, activates)
    Evidence: assay, physical interaction, other species
  • NCI Pathway Database BCR signaling pathway: RAC1 (RAC1) → Bam32/HPK1 complex (DAPP1-MAP4K1) (modification, activates)
    Evidence: assay, physical interaction, other species
  • NCI Pathway Database BCR signaling pathway: RAC1 (RAC1) → MEKK1 (MAP3K1) (modification, activates)
    Evidence: assay, physical interaction, other species
  • NCI Pathway Database BCR signaling pathway: TAK1 (MAP3K7) → Bam32/HPK1 complex (DAPP1-MAP4K1) (modification, activates)
    Evidence: assay, physical interaction, other species
  • NCI Pathway Database BCR signaling pathway: TAK1 (MAP3K7) → MEKK1 (MAP3K1) (modification, activates)
    Evidence: assay, physical interaction, other species
  • NCI Pathway Database BCR signaling pathway: Bam32/HPK1 complex (DAPP1-MAP4K1) → MEKK1 (MAP3K1) (modification, activates)
    Evidence: assay, physical interaction, other species
In total, 12 gene pairs are associated to this article in curated databases