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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining
Mol Cell 2006, PMID: 16916636

Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivo.

Fousteri, Maria; Vermeulen, Wim; van Zeeland, Albert A; Mullenders, Leon H F

Restoration of UV-inhibited transcription requires removal of transcription-blocking DNA lesions by transcription-coupled repair (TCR). In mammals, TCR is dependent on CSA and CSB proteins; however, their functions are largely unknown. Here, we analyzed the composition of UV-stalled transcription elongation complexes from human cells. We show that CSB and CSA display differential roles in recruitment of TCR-specific factors and that assembly for TCR occurs without disruption of the UV-stalled RNA polymerase II (RNAPIIo). CSB fulfills a key role as a coupling factor to attract histone acetyltransferase p300, nucleotide excision repair (NER) proteins, and CSA-DDB1 E3-ubiquitin ligase complex with the COP9 signalosome. CSA is dispensable for attraction of NER proteins to lesion-stalled RNAPIIo, yet in cooperation with CSB is required to recruit XAB2, the nucleosomal binding protein HMGN1, and TFIIS. These results give insight into the nature and order of molecular events that take place during TCR in the context of chromosomal DNA.

Document information provided by NCBI PubMed

Text Mining Data

Dashed line = No text mining data

Manually curated Databases

  • IRef Biogrid Interaction: XAB2 — POLR2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: EP300 — POLR2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: RPA1 — POLR2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: POLR2A — GPS1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: EP300 — ERCC8 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: XPA — POLR2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ERCC4 — POLR2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ERCC6 — RPA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ERCC3 — POLR2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ERCC8 — POLR2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: HMGN1 — ERCC8 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: DDB1 — POLR2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ERCC6 — ERCC3 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: HMGN1 — POLR2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ERCC1 — POLR2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: POLR2A — TCEA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ERCC6 — POLR2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ERCC6 — ERCC8 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ERCC5 — POLR2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ERCC6 — ERCC5 (physical association, affinity chromatography technology)
In total, 20 gene pairs are associated to this article in curated databases