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Gene interactions and pathways from curated databases and text-mining
Clin Cancer Res 2007, PMID: 17505008

AZD2171 shows potent antitumor activity against gastric cancer over-expressing fibroblast growth factor receptor 2/keratinocyte growth factor receptor.

Takeda, Masayuki; Arao, Tokuzo; Yokote, Hideyuki; Komatsu, Teruo; Yanagihara, Kazuyoshi; Sasaki, Hiroki; Yamada, Yasuhide; Tamura, Tomohide; Fukuoka, Kazuya; Kimura, Hiroshi; Saijo, Nagahiro; Nishio, Kazuto

OBJECTIVE

AZD2171 is an oral, highly potent, and selective vascular endothelial growth factor signaling inhibitor that inhibits all vascular endothelial growth factor receptor tyrosine kinases. The purpose of this study was to investigate the activity of AZD2171 in gastric cancer.

METHODS

We examined the antitumor effect of AZD2171 on the eight gastric cancer cell lines in vitro and in vivo.

RESULTS

AZD2171 directly inhibited the growth of two gastric cancer cell lines (KATO-III and OCUM2M), with an IC(50) of 0.15 and 0.37 micromol/L, respectively, more potently than the epidermal growth factor receptor tyrosine kinase inhibitor gefitinib. Reverse transcription-PCR experiments and immunoblotting revealed that sensitive cell lines dominantly expressed COOH terminus-truncated fibroblast growth factor receptor 2 (FGFR2) splicing variants that were constitutively phosphorylated and spontaneously dimerized. AZD2171 completely inhibited the phosphorylation of FGFR2 and downstream signaling proteins (FRS2, AKT, and mitogen-activated protein kinase) in sensitive cell lines at a 10-fold lower concentration (0.1 micromol/L) than in the other cell lines. An in vitro kinase assay showed that AZD2171 inhibited kinase activity of immunoprecipitated FGFR2 with submicromolar K(i) values ( approximately 0.05 micromol/L). Finally, we assessed the antitumor activity of AZD2171 in human gastric tumor xenograft models in mice. Oral administration of AZD2171 (1.5 or 6 mg/kg/d) significantly and dose-dependently inhibited tumor growth in mice bearing KATO-III and OCUM2M tumor xenografts.

CONCLUSIONS

AZD2171 exerted potent antitumor activity against gastric cancer xenografts overexpressing FGFR2. The results of these preclinical studies indicate that AZD2171 may provide clinical benefit in patients with certain types of gastric cancer.

Diseases/Pathways annotated by Medline MESH: Stomach Neoplasms
Document information provided by NCBI PubMed

Text Mining Data

Dashed line = No text mining data

Manually curated Databases

  • Reactome Reaction: FGF17 → FGF22 (reaction)
  • Reactome Reaction: FGFR3 → GAB1 (indirect_complex)
  • Reactome Reaction: FGF16 → FGF22 (reaction)
  • Reactome Reaction: FGFR1 → PIK3R1 (indirect_complex)
  • Reactome Reaction: FGF4 → FGF16 (reaction)
  • Reactome Reaction: FGF2 → FGF8 (reaction)
  • Reactome Reaction: FGF1 → PIK3R1 (reaction)
  • Reactome Reaction: FGF16 → FGF20 (reaction)
  • Reactome Reaction: FGF7 → FGF22 (reaction)
  • Reactome Reaction: FGF1 → PIK3CA (reaction)
  • Reactome Reaction: FGF17 → GRB2 (reaction)
  • Reactome Reaction: FGF23 → FGFR4 (reaction)
  • Reactome Reaction: FGFR3 → FRS2 (indirect_complex)
  • Reactome Reaction: FGFR3 → PIK3R1 (indirect_complex)
  • Reactome Reaction: FGF5 → FGF9 (reaction)
  • Reactome Reaction: FGFR1 → FGFR4 (reaction)
  • Reactome Reaction: FGF17 → FGF17 (reaction)
  • Reactome Reaction: FRS2 → FRS2 (reaction)
  • Reactome Reaction: FGF3 → FGF17 (reaction)
  • Reactome Reaction: FGFR3 → PIK3CA (indirect_complex)
  • Reactome Reaction: FGF9 → FGF10 (reaction)
  • Reactome Reaction: FGF5 → GRB2 (reaction)
  • Reactome Reaction: FGF22 → PIK3R1 (indirect_complex)
  • Reactome Reaction: FGFR4 → FGFR3 (reaction)
  • Reactome Reaction: FGF16 → PIK3CA (reaction)
  • Reactome Reaction: FGF3 → GRB2 (reaction)
  • Reactome Reaction: FGF22 → FRS2 (reaction)
  • Reactome Reaction: FGFR2 → PIK3R1 (reaction)
  • Reactome Reaction: FGF5 → FRS2 (indirect_complex)
  • Reactome Reaction: FGF2 → FGF22 (reaction)
  • Reactome Reaction: FGF7 → PIK3R1 (reaction)
  • Reactome Reaction: FGF5 → PIK3CA (reaction)
  • Reactome Reaction: FGF3 → FGF10 (reaction)
  • Reactome Reaction: FGFR4 → FRS2 (reaction)
  • Reactome Reaction: FGF18 → FGF23 (reaction)
  • Reactome Reaction: FGF4 → FGF7 (reaction)
  • Reactome Reaction: FGF7 → GRB2 (indirect_complex)
  • Reactome Reaction: FGF2 → GAB1 (reaction)
  • Reactome Reaction: FGF1 → FGFR2 (reaction)
  • Reactome Reaction: FGF10 → FGFR3 (reaction)
  • Reactome Reaction: FGF4 → FGF23 (reaction)
  • Reactome Reaction: FGF7 → FGF23 (reaction)
  • Reactome Reaction: FGF6 → PIK3R1 (indirect_complex)
  • Reactome Reaction: GAB1 → FGFR3 (indirect_complex)
  • Reactome Reaction: FGF9 → PIK3R1 (reaction)
  • Reactome Reaction: FGFR2 → PIK3R1 (indirect_complex)
  • Reactome Reaction: FGF8 → FGF20 (reaction)
  • Reactome Reaction: PIK3R1 → FGFR3 (reaction)
  • Reactome Reaction: FGF4 → FGF4 (reaction)
  • Reactome Reaction: FGF23 → GRB2 (reaction)
  • Reactome Reaction: FGF9 → FRS2 (reaction)
  • Reactome Reaction: FGF3 → FGF7 (reaction)
  • Reactome Reaction: FGF18 → FRS2 (indirect_complex)
  • Reactome Reaction: FGF18 → PIK3CA (indirect_complex)
  • Reactome Reaction: FGF23 → FGFR2 (reaction)
  • Reactome Reaction: FGFR4 → FGFR2 (reaction)
  • Reactome Reaction: FGFR2 → PIK3CA (reaction)
  • Reactome Reaction: FGF1 → FGF2 (reaction)
  • Reactome Reaction: FGF5 → FGF8 (reaction)
  • Reactome Reaction: FGF17 → FGFR1 (reaction)
  • Reactome Reaction: FGFR4 → FGFR4 (reaction)
  • Reactome Reaction: FGF5 → PIK3R1 (indirect_complex)
  • Reactome Reaction: FGF23 → PIK3R1 (reaction)
  • Reactome Reaction: FRS2 → FGFR3 (reaction)
  • Reactome Reaction: FGF3 → FGF9 (reaction)
  • Reactome Reaction: FGFR3 → FGFR4 (reaction)
  • Reactome Reaction: FGF8 → GRB2 (reaction)
  • Reactome Reaction: FGF23 → GAB1 (indirect_complex)
  • Reactome Reaction: FGF1 → FRS2 (reaction)
  • Reactome Reaction: FGF20 → FGF23 (reaction)
  • Reactome Reaction: FGF5 → FGF6 (reaction)
  • Reactome Reaction: FGF10 → FGF17 (reaction)
  • Reactome Reaction: FGF17 → FGF18 (reaction)
  • Reactome Reaction: FGF6 → GAB1 (reaction)
  • Reactome Reaction: FGFR2 → GAB1 (reaction)
  • Reactome Reaction: FGF17 → PIK3CA (indirect_complex)
  • Reactome Reaction: FGFR4 → PIK3R1 (indirect_complex)
  • Reactome Reaction: FGF3 → PIK3CA (indirect_complex)
  • Reactome Reaction: FGF8 → GRB2 (indirect_complex)
  • Reactome Reaction: FGF5 → FRS2 (reaction)
  • Reactome Reaction: FGF20 → FGF20 (reaction)
  • Reactome Reaction: FGF1 → FGF1 (reaction)
  • Reactome Reaction: FGF17 → FGFR2 (reaction)
  • Reactome Reaction: FGF6 → FGF8 (reaction)
  • Reactome Reaction: FGFR2 → FRS2 (reaction)
  • Reactome Reaction: FGFR4 → FGFR1 (reaction)
  • Reactome Reaction: FGF18 → FGFR2 (reaction)
  • Reactome Reaction: FGF16 → PIK3R1 (indirect_complex)
  • Reactome Reaction: FGF5 → FGF5 (reaction)
  • Reactome Reaction: FGF10 → FGF10 (reaction)
  • Reactome Reaction: FGF5 → GAB1 (indirect_complex)
  • Reactome Reaction: FGF10 → FGF16 (reaction)
  • Reactome Reaction: FGF4 → FGF17 (reaction)
  • Reactome Reaction: FGF7 → FGF18 (reaction)
  • Reactome Reaction: FGF17 → PIK3R1 (indirect_complex)
  • Reactome Reaction: FGF3 → PIK3R1 (reaction)
  • Reactome Reaction: FGF6 → FGF22 (reaction)
  • Reactome Reaction: FGF9 → FGFR4 (reaction)
  • Reactome Reaction: FGF17 → FRS2 (reaction)
  • Reactome Reaction: FGF8 → GAB1 (reaction)
  • Reactome Reaction: FGF16 → FGF16 (reaction)
  • Reactome Reaction: FGF5 → GRB2 (indirect_complex)
  • Reactome Reaction: FGF20 → FGFR1 (reaction)
  • Reactome Reaction: FGF4 → FGF18 (reaction)
  • Reactome Reaction: FGF16 → GRB2 (indirect_complex)
  • Reactome Reaction: FGF22 → PIK3R1 (reaction)
  • Reactome Reaction: FGF6 → FGFR4 (reaction)
  • Reactome Reaction: FGF2 → FGFR1 (reaction)
  • Reactome Reaction: FGF2 → FGF6 (reaction)
  • Reactome Reaction: FGF4 → GAB1 (indirect_complex)
  • Reactome Reaction: GAB1 → FRS2 (reaction)
  • Reactome Reaction: FGF20 → PIK3R1 (indirect_complex)
  • Reactome Reaction: FGFR3 → FRS2 (reaction)
  • Reactome Reaction: FGF7 → FGF7 (reaction)
  • Reactome Reaction: FGF3 → FGF22 (reaction)
  • Reactome Reaction: FGF4 → FGF9 (reaction)
  • Reactome Reaction: FGF17 → GRB2 (indirect_complex)
  • Reactome Reaction: FGF6 → FGF23 (reaction)
  • Reactome Reaction: FGFR3 → GRB2 (indirect_complex)
  • Reactome Reaction: FGF4 → FGFR1 (reaction)
  • Reactome Reaction: FGF4 → FRS2 (reaction)
  • Reactome Reaction: FGF6 → FRS2 (reaction)
  • Reactome Reaction: FGF2 → FGF16 (reaction)
  • Reactome Reaction: FGF22 → PIK3CA (indirect_complex)
  • Reactome Reaction: FGF3 → GRB2 (indirect_complex)
  • Reactome Reaction: FGF2 → FGF23 (reaction)
  • Reactome Reaction: PIK3CA → PIK3R1 (reaction)
  • Reactome Reaction: FGF2 → GRB2 (reaction)
  • Reactome Reaction: FGF2 → PIK3R1 (indirect_complex)
  • Reactome Reaction: FGF3 → FGF3 (reaction)
  • Reactome Reaction: FGF7 → FGF20 (reaction)
  • Reactome Reaction: FGF8 → FGF9 (reaction)
  • Reactome Reaction: FGF7 → FRS2 (reaction)
  • Reactome Reaction: FGFR3 → GAB1 (reaction)
  • Reactome Reaction: FGFR2 → GRB2 (indirect_complex)
  • Reactome Reaction: PIK3CA → FGFR3 (indirect_complex)
  • Reactome Reaction: FGF22 → FGFR3 (reaction)
  • Reactome Reaction: PIK3CA → FGFR2 (reaction)
  • Reactome Reaction: FGF10 → GRB2 (reaction)
  • Reactome Reaction: FGF6 → GRB2 (reaction)
  • Reactome Reaction: FGFR4 → GAB1 (reaction)
  • Reactome Reaction: FGF17 → FGFR4 (reaction)
  • Reactome Reaction: FGFR2 → FGFR3 (reaction)
  • Reactome Reaction: FGF6 → FGF6 (reaction)
  • Reactome Reaction: FGF18 → FRS2 (reaction)
  • Reactome Reaction: FGF9 → PIK3CA (reaction)
  • Reactome Reaction: FGFR3 → PIK3CA (reaction)
  • Reactome Reaction: FGF5 → FGF23 (reaction)
  • Reactome Reaction: FGF10 → PIK3R1 (reaction)
  • Reactome Reaction: FGF4 → PIK3CA (reaction)
  • Reactome Reaction: FGF2 → FGF7 (reaction)
  • Reactome Reaction: FGF9 → FGFR1 (reaction)
  • Reactome Reaction: GRB2 → FGFR3 (indirect_complex)
  • Reactome Reaction: FGF7 → PIK3R1 (indirect_complex)
  • Reactome Reaction: FGF20 → GAB1 (reaction)
  • Reactome Reaction: FGF7 → GAB1 (reaction)
  • Reactome Reaction: FGFR1 → FRS2 (reaction)
  • Reactome Reaction: FGFR2 → FGFR2 (reaction)
  • Reactome Reaction: FGF8 → FGF10 (reaction)
  • Reactome Reaction: FGF22 → FRS2 (indirect_complex)
  • Reactome Reaction: PIK3R1 → FGFR3 (indirect_complex)
  • Reactome Reaction: FGF5 → FGF22 (reaction)
  • Reactome Reaction: FGFR1 → FGFR2 (reaction)
  • Reactome Reaction: FGF4 → PIK3R1 (reaction)
  • Reactome Reaction: FGF18 → FGF20 (reaction)
  • Reactome Reaction: FGF7 → FGFR2 (reaction)
  • Reactome Reaction: FGF1 → GRB2 (reaction)
  • Reactome Reaction: FGF8 → FGFR1 (reaction)
  • Reactome Reaction: FGF20 → GRB2 (reaction)
  • Reactome Reaction: FGF18 → FGFR3 (reaction)
  • Reactome Reaction: FGF7 → PIK3CA (reaction)
  • Reactome Reaction: FGFR3 → FGFR2 (reaction)
  • Reactome Reaction: FGF18 → FGFR1 (reaction)
  • Reactome Reaction: FGF4 → FGFR4 (reaction)
  • Reactome Reaction: FGFR2 → FGFR1 (reaction)
  • Reactome Reaction: FGF8 → PIK3R1 (reaction)
  • Reactome Reaction: GAB1 → FGFR1 (indirect_complex)
  • Reactome Reaction: FGF1 → FGF5 (reaction)
  • Reactome Reaction: PIK3CA → FGFR1 (reaction)
  • Reactome Reaction: FGFR1 → GRB2 (reaction)
  • Reactome Reaction: FGF2 → FGFR3 (reaction)
  • Reactome Reaction: FGF3 → GAB1 (indirect_complex)
  • Reactome Reaction: FGF23 → PIK3CA (reaction)
  • Reactome Reaction: FGFR1 → FGFR3 (reaction)
  • Reactome Reaction: FGF10 → FGF22 (reaction)
  • Reactome Reaction: FGF2 → FGF10 (reaction)
  • Reactome Reaction: FGF2 → FRS2 (indirect_complex)
  • Reactome Reaction: FGF10 → FGF20 (reaction)
  • Reactome Reaction: FGF6 → FGFR1 (reaction)
  • Reactome Reaction: FRS2 → FGFR2 (indirect_complex)
  • Reactome Reaction: PIK3R1 → FGFR1 (reaction)
  • Reactome Reaction: GRB2 → PIK3CA (reaction)
  • Reactome Reaction: FGF18 → PIK3R1 (indirect_complex)
  • Reactome Reaction: FGF8 → FGF16 (reaction)
  • Reactome Reaction: PIK3CA → FGFR1 (indirect_complex)
  • Reactome Reaction: FGF3 → FGF23 (reaction)
  • Reactome Reaction: FGF2 → FGF20 (reaction)
  • Reactome Reaction: FGF2 → GAB1 (indirect_complex)
  • Reactome Reaction: FGF17 → GAB1 (indirect_complex)
  • Reactome Reaction: FGF1 → FGF10 (reaction)
  • Reactome Reaction: PIK3CA → PIK3R1 (indirect_complex)
  • Reactome Reaction: FGF2 → FGF9 (reaction)
  • Reactome Reaction: FGF18 → FGF18 (reaction)
  • Reactome Reaction: FGFR1 → PIK3CA (reaction)
  • Reactome Reaction: FGF3 → FGF5 (reaction)
  • Reactome Reaction: FGF17 → FRS2 (indirect_complex)
  • Reactome Reaction: PIK3R1 → FRS2 (reaction)
  • Reactome Reaction: FGF10 → PIK3R1 (indirect_complex)
  • Reactome Reaction: FGFR2 → GRB2 (reaction)
  • Reactome Reaction: FGFR3 → FGFR3 (reaction)
  • Reactome Reaction: FGFR2 → FGFR4 (reaction)
  • Reactome Reaction: FGF3 → FGF18 (reaction)
  • Reactome Reaction: FGF20 → FGF22 (reaction)
  • Reactome Reaction: FGF4 → FGF20 (reaction)
  • Reactome Reaction: FGFR1 → GAB1 (indirect_complex)
  • Reactome Reaction: FGF1 → FGFR4 (reaction)
  • Reactome Reaction: FGF2 → PIK3R1 (reaction)
  • Reactome Reaction: FGF6 → FRS2 (indirect_complex)
  • Reactome Reaction: FGF18 → GRB2 (reaction)
  • Reactome Reaction: PIK3CA → GAB1 (indirect_complex)
  • Reactome Reaction: FGF2 → FGF3 (reaction)
  • Reactome Reaction: FGF5 → FGFR2 (reaction)
  • Reactome Reaction: FGF4 → FGF6 (reaction)
  • Reactome Reaction: FGF1 → FGF20 (reaction)
  • Reactome Reaction: FGF10 → FGFR2 (reaction)
  • Reactome Reaction: FGFR1 → PIK3R1 (reaction)
  • Reactome Reaction: FGF6 → FGF16 (reaction)
  • Reactome Reaction: FGF9 → FGF9 (reaction)
  • Reactome Reaction: FGF10 → FGFR1 (reaction)
  • Reactome Reaction: FGF1 → FGF22 (reaction)
  • Reactome Reaction: FGF3 → FGF4 (reaction)
  • Reactome Reaction: FGF16 → FGF23 (reaction)
  • Reactome Reaction: FGF18 → PIK3CA (reaction)
  • Reactome Reaction: PIK3CA → GAB1 (reaction)
  • Reactome Reaction: FGFR4 → GAB1 (indirect_complex)
  • Reactome Reaction: FGF5 → PIK3CA (indirect_complex)
  • Reactome Reaction: FGF3 → FRS2 (reaction)
  • Reactome Reaction: FGF4 → GAB1 (reaction)
  • Reactome Reaction: GRB2 → FGFR2 (indirect_complex)
  • Reactome Reaction: FGF6 → FGF17 (reaction)
  • Reactome Reaction: FGF16 → GAB1 (reaction)
  • Reactome Reaction: FGF8 → PIK3CA (reaction)
  • Reactome Reaction: FGF18 → FGF22 (reaction)
  • Reactome Reaction: FGF17 → FGFR3 (reaction)
  • Reactome Reaction: FGF17 → PIK3R1 (reaction)
  • Reactome Reaction: FGF20 → FRS2 (indirect_complex)
  • Reactome Reaction: FGF20 → PIK3CA (reaction)
  • Reactome Reaction: FGF10 → PIK3CA (indirect_complex)
  • Reactome Reaction: PIK3R1 → FGFR2 (reaction)
  • Reactome Reaction: FGF3 → PIK3CA (reaction)
  • Reactome Reaction: FGF4 → PIK3CA (indirect_complex)
  • Reactome Reaction: FGF17 → PIK3CA (reaction)
  • Reactome Reaction: GRB2 → FGFR2 (reaction)
  • Reactome Reaction: FGF4 → FGF22 (reaction)
  • Reactome Reaction: FGF22 → GAB1 (indirect_complex)
  • Reactome Reaction: FGFR1 → PIK3CA (indirect_complex)
  • Reactome Reaction: FGF16 → GRB2 (reaction)
  • Reactome Reaction: FGF7 → PIK3CA (indirect_complex)
  • Reactome Reaction: FGF9 → PIK3CA (indirect_complex)
  • Reactome Reaction: FGF1 → FGF16 (reaction)
  • Reactome Reaction: FGFR4 → PIK3R1 (reaction)
  • Reactome Reaction: GRB2 → FGFR3 (reaction)
  • Reactome Reaction: FGF18 → GRB2 (indirect_complex)
  • Reactome Reaction: FGF23 → FRS2 (reaction)
  • Reactome Reaction: FGF22 → PIK3CA (reaction)
  • Reactome Reaction: FGF22 → FGF23 (reaction)
  • Reactome Reaction: FGF22 → FGFR4 (reaction)
  • Reactome Reaction: FGF6 → PIK3R1 (reaction)
  • Reactome Reaction: FGF8 → FGF22 (reaction)
  • Reactome Reaction: FGF16 → FGF18 (reaction)
  • Reactome Reaction: FGF10 → FGF18 (reaction)
  • Reactome Reaction: FGF7 → FGF10 (reaction)
  • Reactome Reaction: FGF8 → FGF18 (reaction)
  • Reactome Reaction: FGF8 → GAB1 (indirect_complex)
  • Reactome Reaction: FGF7 → FGF16 (reaction)
  • Reactome Reaction: FGF1 → FGF17 (reaction)
  • Reactome Reaction: FGF7 → FGFR3 (reaction)
  • Reactome Reaction: FGF2 → FGFR2 (reaction)
  • Reactome Reaction: FGF3 → GAB1 (reaction)
  • Reactome Reaction: FGF18 → FGFR4 (reaction)
  • Reactome Reaction: FGF23 → GRB2 (indirect_complex)
  • Reactome Reaction: FGFR4 → GRB2 (reaction)
  • Reactome Reaction: FGF3 → FGF20 (reaction)
  • Reactome Reaction: FGF7 → GAB1 (indirect_complex)
  • Reactome Reaction: FGF16 → PIK3CA (indirect_complex)
  • Reactome Reaction: FGFR4 → PIK3CA (indirect_complex)
  • Reactome Reaction: FGF8 → FGF23 (reaction)
  • Reactome Reaction: FGF9 → FRS2 (indirect_complex)
  • Reactome Reaction: FGF1 → FGF3 (reaction)
  • Reactome Reaction: GAB1 → FGFR2 (reaction)
  • Reactome Reaction: FGF9 → FGFR2 (reaction)
  • Reactome Reaction: FGF17 → GAB1 (reaction)
  • Reactome Reaction: FGF23 → FGFR1 (reaction)
  • Reactome Reaction: FGF8 → PIK3CA (indirect_complex)
  • Reactome Reaction: FGF5 → FGF18 (reaction)
  • Reactome Reaction: FGF5 → FGF7 (reaction)
  • Reactome Reaction: FGF22 → FGF22 (reaction)
  • Reactome Reaction: FGFR1 → FGFR1 (reaction)
  • Reactome Reaction: FGF3 → FRS2 (indirect_complex)
  • Reactome Reaction: FGF10 → GAB1 (indirect_complex)
  • Reactome Reaction: FGF23 → PIK3CA (indirect_complex)
  • Reactome Reaction: FGF8 → FGFR4 (reaction)
  • Reactome Reaction: FGF7 → FGFR1 (reaction)
  • Reactome Reaction: FGF18 → GAB1 (reaction)
  • Reactome Reaction: FGF2 → FGF18 (reaction)
  • Reactome Reaction: FGF6 → FGFR3 (reaction)
  • Reactome Reaction: FGF9 → FGF23 (reaction)
  • Reactome Reaction: FGF1 → FGFR3 (reaction)
  • Reactome Reaction: FGF16 → FRS2 (reaction)
  • Reactome Reaction: FGF8 → FGFR3 (reaction)
  • Reactome Reaction: FGF1 → FGF8 (reaction)
  • Reactome Reaction: FGF9 → PIK3R1 (indirect_complex)
  • Reactome Reaction: FGFR2 → PIK3CA (indirect_complex)
  • Reactome Reaction: FGF5 → FGF17 (reaction)
  • Reactome Reaction: FGF20 → FRS2 (reaction)
  • Reactome Reaction: FGF16 → GAB1 (indirect_complex)
  • Reactome Reaction: FGF6 → GAB1 (indirect_complex)
  • Reactome Reaction: FGF9 → FGF20 (reaction)
  • Reactome Reaction: FGF17 → FGF20 (reaction)
  • Reactome Reaction: FGF23 → PIK3R1 (indirect_complex)
  • Reactome Reaction: FGF2 → FGF17 (reaction)
  • Reactome Reaction: FGF3 → FGFR4 (reaction)
  • Reactome Reaction: FGF4 → FGF10 (reaction)
  • Reactome Reaction: FGF1 → FGF9 (reaction)
  • Reactome Reaction: FGF2 → PIK3CA (indirect_complex)
  • Reactome Reaction: FGF9 → FGF22 (reaction)
  • Reactome Reaction: FGFR4 → GRB2 (indirect_complex)
  • Reactome Reaction: FGF16 → FGFR3 (reaction)
  • Reactome Reaction: FGF2 → PIK3CA (reaction)
  • Reactome Reaction: FGFR1 → FRS2 (indirect_complex)
  • Reactome Reaction: FGF5 → FGFR4 (reaction)
  • Reactome Reaction: FGF22 → GRB2 (indirect_complex)
  • Reactome Reaction: FGFR3 → PIK3R1 (reaction)
  • Reactome Reaction: FGF5 → FGF10 (reaction)
  • Reactome Reaction: FGF20 → PIK3R1 (reaction)
  • Reactome Reaction: FGF10 → PIK3CA (reaction)
  • Reactome Reaction: FGFR3 → FGFR1 (reaction)
  • Reactome Reaction: FGF16 → FGFR1 (reaction)
  • Reactome Reaction: FGF23 → FGFR3 (reaction)
  • Reactome Reaction: FGF7 → FGF17 (reaction)
  • Reactome Reaction: FGF1 → FGF23 (reaction)
  • Reactome Reaction: FGF4 → FGF8 (reaction)
  • Reactome Reaction: FGF1 → FGFR1 (reaction)
  • Reactome Reaction: GRB2 → FGFR1 (indirect_complex)
  • Reactome Reaction: FGF20 → GAB1 (indirect_complex)
  • Reactome Reaction: FGF16 → FGFR2 (reaction)
  • Reactome Reaction: FGF6 → FGF20 (reaction)
  • Reactome Reaction: FGF16 → FGFR4 (reaction)
  • Reactome Reaction: FGFR3 → GRB2 (reaction)
  • Reactome Reaction: FGF9 → FGF17 (reaction)
  • Reactome Reaction: FGF4 → FGF5 (reaction)
  • Reactome Reaction: FRS2 → FGFR1 (reaction)
  • Reactome Reaction: GRB2 → FRS2 (reaction)
  • Reactome Reaction: GRB2 → FRS2 (indirect_complex)
  • Reactome Reaction: FGF8 → PIK3R1 (indirect_complex)
  • Reactome Reaction: FGF4 → GRB2 (indirect_complex)
  • Reactome Reaction: FGF7 → FGF9 (reaction)
  • Reactome Reaction: FGF3 → PIK3R1 (indirect_complex)
  • Reactome Reaction: FGF23 → GAB1 (reaction)
  • Reactome Reaction: FRS2 → FGFR3 (indirect_complex)
  • Reactome Reaction: FGF1 → GAB1 (reaction)
  • Reactome Reaction: FGF2 → FGF2 (reaction)
  • Reactome Reaction: FGF10 → FRS2 (indirect_complex)
  • Reactome Reaction: FGF7 → GRB2 (reaction)
  • Reactome Reaction: FGF1 → FRS2 (indirect_complex)
  • Reactome Reaction: PIK3CA → FGFR2 (indirect_complex)
  • Reactome Reaction: FGF2 → GRB2 (indirect_complex)
  • Reactome Reaction: FRS2 → FGFR2 (reaction)
  • Reactome Reaction: FGF3 → FGF8 (reaction)
  • Reactome Reaction: FGF10 → FRS2 (reaction)
  • Reactome Reaction: FGF22 → GAB1 (reaction)
  • Reactome Reaction: FGF9 → GAB1 (reaction)
  • Reactome Reaction: FGF2 → FGF5 (reaction)
  • Reactome Reaction: FGF1 → GAB1 (indirect_complex)
  • Reactome Reaction: FGF7 → FGFR4 (reaction)
  • Reactome Reaction: FGF3 → FGF6 (reaction)
  • Reactome Reaction: FGF5 → PIK3R1 (reaction)
  • Reactome Reaction: FGF10 → FGFR4 (reaction)
  • Reactome Reaction: FGF6 → PIK3CA (indirect_complex)
  • Reactome Reaction: FGF9 → GAB1 (indirect_complex)
  • Reactome Reaction: FGF9 → FGF16 (reaction)
  • Reactome Reaction: FGF3 → FGFR2 (reaction)
  • Reactome Reaction: FGF2 → FGF4 (reaction)
  • Reactome Reaction: FGF2 → FGFR4 (reaction)
  • Reactome Reaction: FGF20 → FGFR3 (reaction)
  • Reactome Reaction: FGF22 → FGFR1 (reaction)
  • Reactome Reaction: FGF3 → FGF16 (reaction)
  • Reactome Reaction: FGF6 → FGF7 (reaction)
  • Reactome Reaction: FGFR2 → FRS2 (indirect_complex)
  • Reactome Reaction: FGF7 → FGF8 (reaction)
  • Reactome Reaction: FGFR1 → GRB2 (indirect_complex)
  • Reactome Reaction: FGF8 → FRS2 (reaction)
  • Reactome Reaction: FGF22 → GRB2 (reaction)
  • Reactome Reaction: FGF8 → FGF8 (reaction)
  • Reactome Reaction: FGFR2 → GAB1 (indirect_complex)
  • Reactome Reaction: GAB1 → FRS2 (indirect_complex)
  • Reactome Reaction: FGF5 → FGF16 (reaction)
  • Reactome Reaction: FGF6 → FGF18 (reaction)
  • Reactome Reaction: FGF22 → FGFR2 (reaction)
  • Reactome Reaction: PIK3CA → FGFR3 (reaction)
  • Reactome Reaction: GRB2 → FGFR1 (reaction)
  • Reactome Reaction: FGF20 → GRB2 (indirect_complex)
  • Reactome Reaction: PIK3R1 → FRS2 (indirect_complex)
  • Reactome Reaction: FGF9 → FGFR3 (reaction)
  • Reactome Reaction: GRB2 → PIK3CA (indirect_complex)
  • Reactome Reaction: FGF9 → FGF18 (reaction)
  • Reactome Reaction: FGF1 → PIK3CA (indirect_complex)
  • Reactome Reaction: FGF10 → GAB1 (reaction)
  • Reactome Reaction: FGF1 → GRB2 (indirect_complex)
  • Reactome Reaction: FGF10 → GRB2 (indirect_complex)
  • Reactome Reaction: FGF1 → FGF6 (reaction)
  • Reactome Reaction: FGF16 → FGF17 (reaction)
  • Reactome Reaction: FGFR4 → PIK3CA (reaction)
  • Reactome Reaction: FGF20 → PIK3CA (indirect_complex)
  • Reactome Reaction: FGF6 → FGF9 (reaction)
  • Reactome Reaction: FGF18 → PIK3R1 (reaction)
  • Reactome Reaction: FGF23 → FGF23 (reaction)
  • Reactome Reaction: FGF5 → GAB1 (reaction)
  • Reactome Reaction: GAB1 → FGFR1 (reaction)
  • Reactome Reaction: FGF1 → FGF4 (reaction)
  • Reactome Reaction: FGF9 → GRB2 (reaction)
  • Reactome Reaction: PIK3CA → FRS2 (indirect_complex)
  • Reactome Reaction: FGF16 → FRS2 (indirect_complex)
  • Reactome Reaction: FGF18 → GAB1 (indirect_complex)
  • Reactome Reaction: FGF6 → PIK3CA (reaction)
  • Reactome Reaction: GAB1 → FGFR2 (indirect_complex)
  • Reactome Reaction: FGF1 → FGF7 (reaction)
  • Reactome Reaction: FGF6 → FGFR2 (reaction)
  • Reactome Reaction: FGF8 → FGF17 (reaction)
  • Reactome Reaction: FGF7 → FRS2 (indirect_complex)
  • Reactome Reaction: FGF6 → GRB2 (indirect_complex)
  • Reactome Reaction: FGF1 → FGF18 (reaction)
  • Reactome Reaction: FGF23 → FRS2 (indirect_complex)
  • Reactome Reaction: FGF8 → FGFR2 (reaction)
  • Reactome Reaction: FGFR4 → FRS2 (indirect_complex)
  • Reactome Reaction: FGFR1 → GAB1 (reaction)
  • Reactome Reaction: FGF20 → FGFR2 (reaction)
  • Reactome Reaction: FGF4 → FGFR3 (reaction)
  • Reactome Reaction: GAB1 → FGFR3 (reaction)
  • Reactome Reaction: FGF4 → GRB2 (reaction)
  • Reactome Reaction: FGF1 → PIK3R1 (indirect_complex)
  • Reactome Reaction: FGF20 → FGFR4 (reaction)
  • Reactome Reaction: FGF17 → FGF23 (reaction)
  • Reactome Reaction: PIK3R1 → FGFR1 (indirect_complex)
  • Reactome Reaction: FGF10 → FGF23 (reaction)
  • Reactome Reaction: FGF5 → FGF20 (reaction)
  • Reactome Reaction: FRS2 → FGFR1 (indirect_complex)
  • Reactome Reaction: FGF3 → FGFR1 (reaction)
  • Reactome Reaction: FGF6 → FGF10 (reaction)
  • Reactome Reaction: PIK3R1 → FGFR2 (indirect_complex)
  • Reactome Reaction: FGF4 → FGFR2 (reaction)
  • Reactome Reaction: FGF16 → PIK3R1 (reaction)
  • Reactome Reaction: PIK3CA → FRS2 (reaction)
  • Reactome Reaction: FGF4 → FRS2 (indirect_complex)
  • Reactome Reaction: FGF9 → GRB2 (indirect_complex)
  • Reactome Reaction: FGF5 → FGFR1 (reaction)
  • Reactome Reaction: FGF3 → FGFR3 (reaction)
  • Reactome Reaction: FGF2 → FRS2 (reaction)
  • Reactome Reaction: FGF4 → PIK3R1 (indirect_complex)
  • Reactome Reaction: FGF8 → FRS2 (indirect_complex)
  • Reactome Reaction: FGF5 → FGFR3 (reaction)
In total, 318 gene pairs are associated to this article in curated databases