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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining
EMBO Rep 2008, PMID: 18451880

Switching of chromatin-remodelling complexes for oestrogen receptor-alpha.

Okada, Maiko; Takezawa, Shin-ichiro; Mezaki, Yoshihiro; Yamaoka, Ikuko; Takada, Ichiro; Kitagawa, Hirochika; Kato, Shigeaki

The female sex steroid hormone oestrogen stimulates both cell proliferation and cell differentiation in target tissues. These biological actions are mediated primarily through nuclear oestrogen receptors (ERs). The ligand-dependent transactivation of ERs requires several nuclear co-regulator complexes; however, the cell-cycle-dependent associations of these complexes are poorly understood. By using a synchronization system, we found that the transactivation function of ERalpha at G2/M was lowered. Biochemical approaches showed that ERalpha associated with two discrete classes of ATP-dependent chromatin-remodelling complex in a cell-cycle-dependent manner. The components of the NuRD-type complex were identified as G2/M-phase-specific ERalpha co-repressors. Thus, our results indicate that the transactivation function of ERalpha is cell-cycle dependent and is coupled with a cell-cycle-dependent association of chromatin-remodelling complexes.

Document information provided by NCBI PubMed

Text Mining Data

Dashed line = No text mining data

Manually curated Databases

  • IRef Biogrid Interaction: ESR1 — SMARCA4 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MTA2 — ESR1 (direct interaction, pull down)
  • IRef Biogrid Interaction: MTA2 — ESR1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ESR1 — SMARCB1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ESR1 — SMARCC2 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: HDAC1 — ESR1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ESR1 — MTA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ESR1 — MTA1 (direct interaction, pull down)
  • IRef Biogrid Interaction: ESR1 — CHD3 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: SRC — ESR1 (direct interaction, pull down)
  • IRef Biogrid Interaction: MTA3 — ESR1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MTA3 — ESR1 (direct interaction, pull down)
  • IRef Intact Interaction: Complex of ESR1-SMARCC2-SMARCB1-SMARCA4 (association, anti tag coimmunoprecipitation)
  • IRef Intact Interaction: ESR1 — SMARCA4 (physical association, anti bait coimmunoprecipitation)
  • IRef Intact Interaction: ESR1 — SMARCA4 (colocalization, fluorescence microscopy)
  • IRef Intact Interaction: Complex of CHD3-MTA1-HDAC1-ESR1 (association, anti bait coimmunoprecipitation)
  • IRef Intact Interaction: MTA2 — ESR1 (physical association, pull down)
  • IRef Intact Interaction: NCOA1 — ESR1 (physical association, pull down)
  • IRef Intact Interaction: ESR1 — MTA1 (physical association, pull down)
  • IRef Intact Interaction: ESR1 — CHD3 (colocalization, fluorescence microscopy)
  • IRef Intact Interaction: ESR1 — MTA3 (physical association, pull down)
  • IRef Intact Interaction: Complex of 13 proteins (association, anti tag coimmunoprecipitation)
In total, 23 gene pairs are associated to this article in curated databases